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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
STZ icon
376
Constellation Brands
STZ
$22.9B
$4.17K ﹤0.01%
31
-2
-6% -$318
GPC icon
377
Genuine Parts
GPC
$18.5B
$4.16K ﹤0.01%
30
– –
PKG icon
378
Packaging Corp of America
PKG
$22.8B
$4.14K ﹤0.01%
19
– –
GDDY icon
379
GoDaddy
GDDY
$11.6B
$4.11K ﹤0.01%
30
– –
APTV icon
380
Aptiv
APTV
$10.1B
$4.05K ﹤0.01%
47
-2
-4% -$151
AMCR icon
381
Amcor
AMCR
$21.5B
$4.05K ﹤0.01%
99
– –
DLTR icon
382
Dollar Tree
DLTR
$24.7B
$3.96K ﹤0.01%
42
-1
-2% -$107
WST icon
383
West Pharmaceutical
WST
$24.8B
$3.94K ﹤0.01%
15
– –
J icon
384
Jacobs Solutions
J
$17B
$3.9K ﹤0.01%
26
– –
FFIV icon
385
F5
FFIV
$24B
$3.88K ﹤0.01%
12
– –
PNR icon
386
Pentair
PNR
$10.5B
$3.88K ﹤0.01%
35
– –
CTRA
387
DELISTED
Coterra Energy
CTRA
$3.85K ﹤0.01%
163
+4
+3% +$96
WY icon
388
Weyerhaeuser
WY
$17.8B
$3.84K ﹤0.01%
155
-1
-0.6% -$26
SNA icon
389
Snap-on
SNA
$21.1B
$3.81K ﹤0.01%
11
– –
KEY icon
390
KeyCorp
KEY
$24.5B
$3.76K ﹤0.01%
201
-14
-7% -$259
TPL icon
391
Texas Pacific Land
TPL
$23.6B
$3.73K ﹤0.01%
12
– –
EVRG icon
392
Evergy
EVRG
$19.2B
$3.73K ﹤0.01%
49
– –
L icon
393
Loews
L
$23.1B
$3.71K ﹤0.01%
37
-1
-3% -$95
LNT icon
394
Alliant Energy
LNT
$18.2B
$3.71K ﹤0.01%
55
– –
EXPD icon
395
Expeditors International
EXPD
$24B
$3.68K ﹤0.01%
30
– –
PFG icon
396
Principal Financial Group
PFG
$24.4B
$3.65K ﹤0.01%
44
-1
-2% -$80
MKC icon
397
McCormick & Company Non-Voting
MKC
$14.2B
$3.61K ﹤0.01%
54
– –
LUV icon
398
Southwest Airlines
LUV
$22B
$3.61K ﹤0.01%
113
-15
-12% -$491
CNC icon
399
Centene
CNC
$33.1B
$3.6K ﹤0.01%
101
-6
-6% -$181
LVS icon
400
Las Vegas Sands
LVS
$29.6B
$3.6K ﹤0.01%
67
-7
-9% -$368
14 15
16
17 18

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SSC
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ACM
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MCM
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MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.