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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
SW
351
Smurfit Westrock
SW
$25.8B
$4.77K ﹤0.01%
112
+6
+6% +$272
DRI icon
352
Darden Restaurants
DRI
$25.9B
$4.76K ﹤0.01%
25
– –
K
353
DELISTED
Kellanova
K
$4.76K ﹤0.01%
58
– –
HUBB icon
354
Hubbell
HUBB
$27.1B
$4.73K ﹤0.01%
11
– –
TYL icon
355
Tyler Technologies
TYL
$13B
$4.71K ﹤0.01%
9
– –
CMS icon
356
CMS Energy
CMS
$22B
$4.69K ﹤0.01%
64
– –
TTD icon
357
Trade Desk
TTD
$6.34B
$4.66K ﹤0.01%
+95
New +$6.03K
CHD icon
358
Church & Dwight Co
CHD
$24B
$4.64K ﹤0.01%
53
– –
PODD icon
359
Insulet
PODD
$10.1B
$4.63K ﹤0.01%
15
– –
EIX icon
360
Edison International
EIX
$26.7B
$4.59K ﹤0.01%
83
– –
DGX icon
361
Quest Diagnostics
DGX
$26.2B
$4.57K ﹤0.01%
24
+1
+4% +$177
HAL icon
362
Halliburton
HAL
$27.7B
$4.53K ﹤0.01%
184
-3
-2% -$66
CDW icon
363
CDW
CDW
$17.1B
$4.46K ﹤0.01%
28
– –
SBAC icon
364
SBA Communications
SBAC
$19.4B
$4.45K ﹤0.01%
23
– –
EL icon
365
Estee Lauder
EL
$31.7B
$4.41K ﹤0.01%
50
– –
GPN icon
366
Global Payments
GPN
$23.4B
$4.4K ﹤0.01%
53
– –
NI icon
367
NiSource
NI
$20.1B
$4.37K ﹤0.01%
101
– –
BIIB icon
368
Biogen
BIIB
$30.9B
$4.34K ﹤0.01%
31
– –
ON icon
369
ON Semiconductor
ON
$32.4B
$4.34K ﹤0.01%
88
-3
-3% -$158
CPAY icon
370
Corpay
CPAY
$26.9B
$4.32K ﹤0.01%
15
– –
LULU icon
371
lululemon athletica
LULU
$13.7B
$4.27K ﹤0.01%
24
– –
TRMB icon
372
Trimble
TRMB
$13.1B
$4.25K ﹤0.01%
52
-1
-2% -$82
ZBH icon
373
Zimmer Biomet
ZBH
$18.7B
$4.24K ﹤0.01%
43
– –
IT icon
374
Gartner
IT
$11.3B
$4.21K ﹤0.01%
16
– –
STLD icon
375
Steel Dynamics
STLD
$37.7B
$4.18K ﹤0.01%
30
– –
13 14
15
16 17

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VM
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SSC
Spruce Street Capital New York $416M AUM
ACM
Alight Capital Management New York $417M AUM 98.18% 1-Year Est. Return
MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
Milestone Investment Advisors Middleton, Wisconsin $414M AUM 12.76% 1-Year Est. Return
SP
Sequent Planning Omaha, Nebraska $414M AUM 14.63% 1-Year Est. Return
SWC
Square Wave Capital Brooklyn, New York $413M AUM 15.36% 1-Year Est. Return
VIS
Vega Investment Solutions Paris, France $418M AUM

Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.