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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AWK icon
301
American Water Works
AWK
$26.8B
$5.85K ﹤0.01%
42
– –
EME icon
302
Emcor
EME
$36.8B
$5.85K ﹤0.01%
+9
New +$5.46K
BRO icon
303
Brown & Brown
BRO
$23.8B
$5.82K ﹤0.01%
62
+11
+22% +$1.07K
ATO icon
304
Atmos Energy
ATO
$28.7B
$5.81K ﹤0.01%
34
– –
HSY icon
305
Hershey
HSY
$37B
$5.8K ﹤0.01%
31
– –
GIS icon
306
General Mills
GIS
$20.4B
$5.8K ﹤0.01%
115
-4
-3% -$201
AVB icon
307
AvalonBay Communities
AVB
$25.7B
$5.79K ﹤0.01%
30
– –
FANG icon
308
Diamondback Energy
FANG
$56.2B
$5.72K ﹤0.01%
40
– –
SYF icon
309
Synchrony
SYF
$25.8B
$5.68K ﹤0.01%
80
-4
-5% -$290
PHM icon
310
Pultegroup
PHM
$24.6B
$5.68K ﹤0.01%
43
– –
NTRS icon
311
Northern Trust
NTRS
$35B
$5.65K ﹤0.01%
42
– –
DXCM icon
312
DexCom
DXCM
$34.3B
$5.65K ﹤0.01%
84
– –
VLTO icon
313
Veralto
VLTO
$23.6B
$5.65K ﹤0.01%
53
– –
ODFL icon
314
Old Dominion Freight Line
ODFL
$44.1B
$5.63K ﹤0.01%
40
– –
ES icon
315
Eversource Energy
ES
$26.9B
$5.62K ﹤0.01%
79
– –
EXPE icon
316
Expedia Group
EXPE
$39.1B
$5.56K ﹤0.01%
26
– –
CHTR icon
317
Charter Communications
CHTR
$17.9B
$5.5K ﹤0.01%
20
– –
HPQ icon
318
HP
HPQ
$26.8B
$5.5K ﹤0.01%
202
– –
ULTA icon
319
Ulta Beauty
ULTA
$22.9B
$5.47K ﹤0.01%
10
– –
CNP icon
320
CenterPoint Energy
CNP
$26.7B
$5.43K ﹤0.01%
140
– –
HBAN icon
321
Huntington Bancshares
HBAN
$36.1B
$5.42K ﹤0.01%
314
– –
EXE
322
Expand Energy Corp
EXE
$22.3B
$5.42K ﹤0.01%
51
+6
+13% +$602
CBOE icon
323
Cboe Global Markets
CBOE
$30.4B
$5.4K ﹤0.01%
22
– –
LYV icon
324
Live Nation Entertainment
LYV
$43.2B
$5.39K ﹤0.01%
33
– –
LDOS icon
325
Leidos
LDOS
$17.6B
$5.29K ﹤0.01%
28
– –
11 12
13
14 15

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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.