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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
IQV icon
276
IQVIA
IQV
$39.8B
$6.84K ﹤0.01%
36
– –
NRG icon
277
NRG Energy
NRG
$25.4B
$6.8K ﹤0.01%
42
-1
-2% -$156
VTR icon
278
Ventas
VTR
$45.7B
$6.79K ﹤0.01%
97
+3
+3% +$202
NUE icon
279
Nucor
NUE
$61.7B
$6.77K ﹤0.01%
50
– –
HUM icon
280
Humana
HUM
$46.7B
$6.76K ﹤0.01%
26
– –
UAL icon
281
United Airlines
UAL
$40.6B
$6.75K ﹤0.01%
70
-1
-1% -$96
CCL icon
282
Carnival Corporation Ltd
CCL
$37.9B
$6.74K ﹤0.01%
233
+7
+3% +$211
RJF icon
283
Raymond James Financial
RJF
$34.9B
$6.73K ﹤0.01%
39
– –
MTB icon
284
M&T Bank
MTB
$36.6B
$6.72K ﹤0.01%
34
-1
-3% -$196
KVUE icon
285
Kenvue
KVUE
$36.5B
$6.7K ﹤0.01%
413
-1
-0.2% -$20
EFX icon
286
Equifax
EFX
$21.2B
$6.67K ﹤0.01%
26
– –
IBKR icon
287
Interactive Brokers
IBKR
$41.5B
$6.61K ﹤0.01%
+96
New +$6.04K
TSCO icon
288
Tractor Supply
TSCO
$19B
$6.48K ﹤0.01%
114
-1
-0.9% -$59
KEYS icon
289
Keysight
KEYS
$60.6B
$6.47K ﹤0.01%
37
– –
IR icon
290
Ingersoll Rand
IR
$32.9B
$6.44K ﹤0.01%
78
-9
-10% -$738
IRM icon
291
Iron Mountain
IRM
$37B
$6.42K ﹤0.01%
63
– –
FITB
292
Fifth Third Bancorp
FITB
$52.6B
$6.37K ﹤0.01%
143
-1
-0.7% -$44
EXR icon
293
Extra Space Storage
EXR
$31B
$6.34K ﹤0.01%
45
– –
DTE icon
294
DTE Energy
DTE
$28.9B
$6.22K ﹤0.01%
44
– –
LEN icon
295
Lennar Class A
LEN
$20.5B
$6.18K ﹤0.01%
49
-1
-2% -$124
ADM icon
296
Archer Daniels Midland
ADM
$38.4B
$6.15K ﹤0.01%
103
– –
AEE icon
297
Ameren
AEE
$30.1B
$6.05K ﹤0.01%
58
– –
BR icon
298
Broadridge
BR
$19.3B
$5.95K ﹤0.01%
25
– –
PPL
299
PPL Corp
PPL
$26.7B
$5.91K ﹤0.01%
159
– –
TDY icon
300
Teledyne Technologies
TDY
$31.8B
$5.86K ﹤0.01%
10
– –
10 11
12
13 14

Similar funds

VM
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SSC
Spruce Street Capital New York $416M AUM
ACM
Alight Capital Management New York $417M AUM 98.18% 1-Year Est. Return
MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
Milestone Investment Advisors Middleton, Wisconsin $414M AUM 12.76% 1-Year Est. Return
SP
Sequent Planning Omaha, Nebraska $414M AUM 14.63% 1-Year Est. Return
SWC
Square Wave Capital Brooklyn, New York $413M AUM 15.36% 1-Year Est. Return
VIS
Vega Investment Solutions Paris, France $418M AUM

Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.