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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DAL icon
251
Delta Air Lines
DAL
$59.1B
$7.89K ﹤0.01%
139
+1
+0.7% +$57
PRU icon
252
Prudential Financial
PRU
$42.3B
$7.88K ﹤0.01%
76
– –
TRGP icon
253
Targa Resources
TRGP
$57.6B
$7.87K ﹤0.01%
47
– –
A icon
254
Agilent Technologies
A
$41.9B
$7.83K ﹤0.01%
61
– –
OTIS icon
255
Otis Worldwide
OTIS
$28.2B
$7.77K ﹤0.01%
85
– –
ED icon
256
Consolidated Edison
ED
$39.9B
$7.74K ﹤0.01%
77
+3
+4% +$301
CSGP icon
257
CoStar Group
CSGP
$12.4B
$7.68K ﹤0.01%
91
– –
XYL icon
258
Xylem
XYL
$28.5B
$7.67K ﹤0.01%
52
– –
VRSK icon
259
Verisk Analytics
VRSK
$23.5B
$7.54K ﹤0.01%
30
– –
FICO icon
260
Fair Isaac
FICO
$22.6B
$7.48K ﹤0.01%
5
– –
VICI icon
261
VICI Properties
VICI
$28.7B
$7.47K ﹤0.01%
229
+2
+0.9% +$66
FIS icon
262
Fidelity National Information Services
FIS
$21.6B
$7.45K ﹤0.01%
113
-1
-0.9% -$73
MCHP icon
263
Microchip Technology
MCHP
$43.1B
$7.45K ﹤0.01%
116
– –
KDP icon
264
Keurig Dr Pepper
KDP
$40.2B
$7.45K ﹤0.01%
292
-1
-0.3% -$31
GEHC icon
265
GE HealthCare
GEHC
$32.6B
$7.36K ﹤0.01%
98
– –
EQT icon
266
EQT Corp
EQT
$33.8B
$7.29K ﹤0.01%
134
+6
+5% +$317
OXY icon
267
Occidental Petroleum
OXY
$58.5B
$7.28K ﹤0.01%
154
+8
+5% +$361
ACGL icon
268
Arch Capital
ACGL
$33.2B
$7.26K ﹤0.01%
80
-1
-1% -$90
WTW icon
269
Willis Towers Watson
WTW
$31.6B
$7.25K ﹤0.01%
21
– –
WAB icon
270
Wabtec
WAB
$49.9B
$7.22K ﹤0.01%
36
– –
PCG icon
271
PG&E
PCG
$38.3B
$7.12K ﹤0.01%
472
-3
-0.6% -$44
STT icon
272
State Street
STT
$52.2B
$7.08K ﹤0.01%
61
-1
-2% -$112
CTSH icon
273
Cognizant
CTSH
$26.2B
$7.04K ﹤0.01%
105
-1
-0.9% -$72
DD icon
274
DuPont de Nemours
DD
$19.5B
$7.01K ﹤0.01%
72
– –
HPE icon
275
Hewlett Packard
HPE
$77.8B
$6.93K ﹤0.01%
282
-1
-0.4% -$22
9 10
11
12 13

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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
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SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.