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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
-7.04%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$416M
AUM Growth
+$241M
Cap. Flow
+$269M
Cap. Flow %
64.6%
Top 10 Hldgs %
83.32%
Holding
503
New
3
Increased
27
Reduced
1
Closed
472

Top Buys

Rank Stock Value
1
NVDA icon
NVIDIA
NVDA
+$58.1M
2
AAPL icon
Apple
AAPL
+$50.9M
3
GOOGL icon
Alphabet (Google) Class A
GOOGL
+$44.7M
4
MSFT icon
Microsoft
MSFT
+$42.1M
5
AMZN icon
Amazon
AMZN
+$28.8M

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$102M
2
GOOG icon
Alphabet (Google) Class C
GOOG
+$314K
3
BRK.B icon
Berkshire Hathaway Class B
BRK.B
+$199K
4
JPM icon
JPMorgan Chase
JPM
+$189K
5
LLY icon
Eli Lilly
LLY
+$184K

Sector Composition

Rank Sector Weight
1 Technology 59.32%
2 Communication Services 16.1%
3 Consumer Discretionary 10.79%
4 Financials 0%
5 Healthcare 0%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
HSY icon
251
Hershey
HSY
$35.2B
– –
-31
Closed -$5.64K
HUBB icon
252
Hubbell
HUBB
$25B
– –
-11
Closed -$4.88K
HUM icon
253
Humana
HUM
$43.7B
– –
-26
Closed -$6.66K
HWM icon
254
Howmet Aerospace
HWM
$113B
– –
-87
Closed -$17.8K
IBKR icon
255
Interactive Brokers
IBKR
$39.2B
– –
-96
Closed -$6.17K
ICE icon
256
Intercontinental Exchange
ICE
$85.6B
– –
-123
Closed -$19.9K
IDXX icon
257
Idexx Laboratories
IDXX
$44.1B
– –
-17
Closed -$11.5K
IEX icon
258
IDEX
IEX
$17B
– –
-16
Closed -$2.85K
IFF icon
259
International Flavors & Fragrances
IFF
$20.2B
– –
-55
Closed -$3.71K
INVH icon
260
Invitation Homes
INVH
$17.7B
– –
-122
Closed -$3.39K
IP icon
261
International Paper
IP
$21.6B
– –
-113
Closed -$4.45K
IQV icon
262
IQVIA
IQV
$38.7B
– –
-36
Closed -$8.12K
IR icon
263
Ingersoll Rand
IR
$32.6B
– –
-78
Closed -$6.18K
IRM icon
264
Iron Mountain
IRM
$36.4B
– –
-63
Closed -$5.23K
ISRG icon
265
Intuitive Surgical
ISRG
$127B
– –
-77
Closed -$43.6K
IT icon
266
Gartner
IT
$10.1B
– –
-16
Closed -$4.04K
ITW icon
267
Illinois Tool Works
ITW
$82.6B
– –
-57
Closed -$14K
IVZ icon
268
Invesco
IVZ
$13.1B
– –
-96
Closed -$2.52K
J icon
269
Jacobs Solutions
J
$15.9B
– –
-26
Closed -$3.44K
JBHT icon
270
JB Hunt Transport Services
JBHT
$25.5B
– –
-17
Closed -$3.3K
JBL icon
271
Jabil
JBL
$33B
– –
-23
Closed -$5.24K
JCI icon
272
Johnson Controls International
JCI
$88.8B
– –
-132
Closed -$15.8K
JKHY icon
273
Jack Henry & Associates
JKHY
$10.9B
– –
-15
Closed -$2.74K
JNJ icon
274
Johnson & Johnson
JNJ
$618B
– –
-520
Closed -$108K
JPM icon
275
JPMorgan Chase
JPM
$935B
– –
-588
Closed -$189K
9 10
11
12 13

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SCP
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SSC
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SSC
Syverson Strege & Co West Des Moines, Iowa $416M AUM 21.16% 1-Year Est. Return
CEI
Clark Estates Inc New York $416M AUM 6.04% 1-Year Est. Return
I
InceptionR Lafayette, California $415M AUM 17.85% 1-Year Est. Return
AWCI
Alpine Woods Capital Investors Purchase, New York $417M AUM 26.83% 1-Year Est. Return
SCMS
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Howard Hughes Medical Institute's Q1 2026 Portfolio in Review

As of Q1 2026, Howard Hughes Medical Institute held 503 positions worth $416M, up 138% from $175M the previous quarter. Its ten largest holdings account for 83% of the portfolio.

Howard Hughes Medical Institute deployed $269M of net new capital in Q1 2026, opening 3 new positions and adding to 27 existing holdings. Its largest new stake was TSMC: 66,773 shares worth $22.6M.

By sector, the portfolio is most concentrated in Technology at 59% of assets, up from 2.5% a quarter earlier, followed by Communication Services and Consumer Discretionary.

On the sell side, the largest reduction was State Street SPDR S&P 500 ETF Trust, an estimated $102M trimmed.

  • Howard Hughes Medical Institute's largest Q1 2026 buy was TSMC: 66,773 shares worth $22.6M.
  • Howard Hughes Medical Institute added most to NVIDIA in Q1 2026, an estimated $58.1M increase.
  • Howard Hughes Medical Institute's biggest Q1 2026 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $102M.
  • Howard Hughes Medical Institute fully exited Alphabet (Google) Class C in Q1 2026, selling an estimated $314K.
  • Howard Hughes Medical Institute's ten largest holdings make up 83% of its $416M portfolio in Q1 2026.
  • Howard Hughes Medical Institute opened 3 new positions and closed 472 in Q1 2026.
  • Howard Hughes Medical Institute's portfolio value rose 138% quarter-over-quarter to $416M.

Based on Howard Hughes Medical Institute's 13F filing for Q1 2026, filed 15 May 2026.