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HHMI

Howard Hughes Medical Institute Portfolio holdings

AUM $416M
1-Year Est. Return 13.82%
This Fund
S&P 500
This Quarter Est. Return
+7.99%
1 Year Est. Return
+13.82%
3 Year Est. Return
+59.34%
5 Year Est. Return
+48.21%
10 Year Est. Return
+227.75%
AUM
$171M
AUM Growth
-$80.3M
Cap. Flow
-$96.1M
Cap. Flow %
-56.34%
Top 10 Hldgs %
95.55%
Holding
509
New
8
Increased
62
Reduced
141
Closed
9

Top Buys

Rank Stock Value
1
APP icon
Applovin
APP
+$26.7K
2
HOOD icon
Robinhood
HOOD
+$18.1K
3
AMZN icon
Amazon
AMZN
+$10.2K
4
DDOG icon
Datadog
DDOG
+$9.5K
5
XYZ
Block Inc
XYZ
+$8.91K

Top Sells

Rank Stock Value
1
SPY icon
State Street SPDR S&P 500 ETF Trust
SPY
+$96.2M
2
AAPL icon
Apple
AAPL
+$9.94K
3
HES
Hess
HES
+$8.17K
4
NVDA icon
NVIDIA
NVDA
+$7.84K
5
MSFT icon
Microsoft
MSFT
+$7.14K

Sector Composition

Rank Sector Weight
1 Technology 2.56%
2 Financials 0.95%
3 Consumer Discretionary 0.76%
4 Communication Services 0.75%
5 Healthcare 0.64%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
MPWR icon
226
Monolithic Power Systems
MPWR
$70B
$9.21K 0.01%
10
– –
YUM icon
227
Yum! Brands
YUM
$41B
$9.12K 0.01%
60
– –
MSCI icon
228
MSCI
MSCI
$40.9B
$9.08K 0.01%
16
– –
WDC icon
229
Western Digital
WDC
$157B
$9.01K 0.01%
75
– –
EBAY icon
230
eBay
EBAY
$45.5B
$9K 0.01%
99
-4
-4% -$354
CCI icon
231
Crown Castle
CCI
$31.5B
$8.97K 0.01%
93
– –
PEG icon
232
Public Service Enterprise Group
PEG
$37.8B
$8.93K 0.01%
107
– –
ETR icon
233
Entergy
ETR
$50.3B
$8.85K 0.01%
95
+3
+3% +$264
KR icon
234
Kroger
KR
$34.3B
$8.83K 0.01%
131
-12
-8% -$835
KMB icon
235
Kimberly-Clark
KMB
$36.2B
$8.83K 0.01%
71
– –
TGT icon
236
Target
TGT
$69.9B
$8.79K 0.01%
98
-1
-1% -$98
PAYX icon
237
Paychex
PAYX
$42.8B
$8.75K 0.01%
69
– –
GRMN
238
Garmin
GRMN
$59.8B
$8.62K 0.01%
35
+2
+6% +$461
VMC icon
239
Vulcan Materials
VMC
$36.3B
$8.61K 0.01%
28
– –
XYZ
240
Block Inc
XYZ
$47B
$8.6K 0.01%
+119
New +$8.91K
CPRT icon
241
Copart
CPRT
$26.8B
$8.59K 0.01%
191
+2
+1% +$94
NDAQ icon
242
Nasdaq
NDAQ
$53.5B
$8.58K 0.01%
97
+8
+9% +$741
GWW icon
243
W.W. Grainger
GWW
$61.5B
$8.58K 0.01%
9
– –
RMD icon
244
ResMed
RMD
$32.8B
$8.49K 0.01%
31
– –
SYY icon
245
Sysco
SYY
$40.5B
$8.48K 0.01%
103
-2
-2% -$160
ROK icon
246
Rockwell Automation
ROK
$50.1B
$8.39K ﹤0.01%
24
– –
MLM icon
247
Martin Marietta Materials
MLM
$32.7B
$8.19K ﹤0.01%
13
– –
CAH icon
248
Cardinal Health
CAH
$54.5B
$8.16K ﹤0.01%
52
– –
HIG icon
249
Hartford Financial Services
HIG
$37.7B
$8.14K ﹤0.01%
61
-1
-2% -$128
WEC icon
250
WEC Energy
WEC
$35.6B
$7.91K ﹤0.01%
69
+1
+1% +$108
8 9
10
11 12

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VM
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SSC
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ACM
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MCM
Millstreet Capital Management Boston, Massachusetts $418M AUM 80.77% 1-Year Est. Return
MIA
Milestone Investment Advisors Middleton, Wisconsin $414M AUM 12.76% 1-Year Est. Return
SP
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SWC
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VIS
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Howard Hughes Medical Institute's Q3 2025 Portfolio in Review

As of Q3 2025, Howard Hughes Medical Institute held 509 positions worth $171M, down 32% from $251M the previous quarter. Its ten largest holdings account for 96% of the portfolio.

Howard Hughes Medical Institute withdrew a net $96.1M in Q3 2025, closing 9 positions and reducing 141 holdings. Its most notable exit was Hess, an estimated $8.17K position sold in full.

By sector, the portfolio is most concentrated in Technology at 2.6% of assets, up from 1.6% a quarter earlier, followed by Financials and Consumer Discretionary.

Against the trend, Howard Hughes Medical Institute opened a new position in Applovin worth $41.7K.

  • Howard Hughes Medical Institute's largest Q3 2025 buy was Applovin: 58 shares worth $41.7K.
  • Howard Hughes Medical Institute added most to Amazon in Q3 2025, an estimated $10.2K increase.
  • Howard Hughes Medical Institute's biggest Q3 2025 reduction was State Street SPDR S&P 500 ETF Trust, cutting an estimated $96.2M.
  • Howard Hughes Medical Institute fully exited Hess in Q3 2025, selling an estimated $8.17K.
  • Howard Hughes Medical Institute's ten largest holdings make up 96% of its $171M portfolio in Q3 2025.
  • Howard Hughes Medical Institute opened 8 new positions and closed 9 in Q3 2025.
  • Howard Hughes Medical Institute's portfolio value fell 32% quarter-over-quarter to $171M.

Based on Howard Hughes Medical Institute's 13F filing for Q3 2025, filed 14 Nov 2025.