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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
-4.54%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$260M
AUM Growth
-$9.28M
Cap. Flow
+$13.5M
Cap. Flow %
5.19%
Top 10 Hldgs %
25.84%
Holding
172
New
35
Increased
39
Reduced
27
Closed
24

Top Buys

Rank Stock Value
1
PWR icon
Quanta Services
PWR
+$2.34M
2
MTZ icon
MasTec
MTZ
+$2.2M
3
MA icon
Mastercard
MA
+$2.01M
4
IMVT icon
Immunovant
IMVT
+$2M
5
MMM icon
3M
MMM
+$1.98M

Top Sells

Rank Stock Value
1
HCP
HashiCorp, Inc. Class A Common Stock
HCP
+$4.45M
2
AMZN icon
Amazon
AMZN
+$3.36M
3
TEVA icon
Teva Pharmaceuticals
TEVA
+$2.23M
4
LYV icon
Live Nation Entertainment
LYV
+$2.02M
5
GH icon
Guardant Health
GH
+$1.83M

Sector Composition

Rank Sector Weight
1 Healthcare 39.15%
2 Technology 17.75%
3 Industrials 8.61%
4 Consumer Discretionary 6.17%
5 Financials 5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DBC icon
1
Invesco DB Commodity Index Tracking Fund
DBC
$1.69B
$32.3M 12.45%
1,436,136
– –
HES
2
DELISTED
Hess
HES
$4.62M 1.78%
28,900
– –
JNPR
3
DELISTED
Juniper Networks
JNPR
$4.15M 1.6%
114,700
– –
ACI icon
4
Albertsons Companies
ACI
$5.62B
$4.15M 1.6%
188,753
– –
ANSS
5
DELISTED
Ansys
ANSS
$4.05M 1.56%
12,800
– –
PTGX icon
6
Protagonist Therapeutics
PTGX
$8.79B
$3.79M 1.46%
78,452
+15,934
+25% +$668K
MSFT icon
7
Microsoft
MSFT
$3.45T
$3.66M 1.41%
9,758
-800
-8% -$326K
AMED
8
DELISTED
Amedisys
AMED
$3.64M 1.4%
39,250
– –
AMZN icon
9
Amazon
AMZN
$2.92T
$3.56M 1.37%
18,693
-15,500
-45% -$3.36M
ACLX
10
DELISTED
Arcellx
ACLX
$3.12M 1.2%
47,496
+3,692
+8% +$250K
DVAX
11
DELISTED
Dynavax Technologies
DVAX
$3.05M 1.18%
235,172
-63,364
-21% -$838K
SWTX
12
DELISTED
SpringWorks Therapeutics
SWTX
$3.03M 1.17%
68,758
– –
LQDA icon
13
Liquidia Corp
LQDA
$7.48B
$3M 1.16%
203,510
– –
GEV icon
14
GE Vernova
GEV
$264B
$2.99M 1.15%
9,800
+3,000
+44% +$1.05M
XPO icon
15
XPO
XPO
$23.6B
$2.89M 1.11%
26,880
+1,100
+4% +$140K
NUVL
16
DELISTED
Nuvalent
NUVL
$2.83M 1.09%
39,876
– –
AVGO icon
17
Broadcom
AVGO
$1.85T
$2.66M 1.03%
15,900
+6,800
+75% +$1.44M
RVMD icon
18
Revolution Medicines
RVMD
$39.9B
$2.61M 1%
73,752
+16,506
+29% +$670K
AXSM icon
19
Axsome Therapeutics
AXSM
$11.2B
$2.51M 0.97%
21,503
+4,379
+26% +$499K
CRM icon
20
Salesforce
CRM
$151B
$2.49M 0.96%
9,285
-300
-3% -$93.3K
VRDN icon
21
Viridian Therapeutics
VRDN
$2.09B
$2.43M 0.94%
180,551
+25,988
+17% +$443K
APLS
22
DELISTED
Apellis Pharmaceuticals
APLS
$2.38M 0.92%
108,714
– –
INTU icon
23
Intuit
INTU
$86.5B
$2.37M 0.91%
3,863
+1,300
+51% +$781K
ALKS icon
24
Alkermes
ALKS
$8.22B
$2.34M 0.9%
70,762
+16,316
+30% +$532K
MRUS
25
DELISTED
Merus
MRUS
$2.32M 0.89%
55,039
– –
1
2 3 4 5

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BHBT
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WTFG
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VIA
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A6
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HighVista Strategies's Q1 2025 Portfolio in Review

As of Q1 2025, HighVista Strategies held 172 positions worth $260M, down 3.5% from $269M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies deployed $13.5M of net new capital in Q1 2025, opening 35 new positions and adding to 39 existing holdings. Its largest new stake was Quanta Services: 8,100 shares worth $2.06M.

By sector, the portfolio is most concentrated in Healthcare at 39% of assets, down from 44% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Amazon, an estimated $3.36M trimmed.

  • HighVista Strategies's largest Q1 2025 buy was Quanta Services: 8,100 shares worth $2.06M.
  • HighVista Strategies added most to Praxis Precision Medicines in Q1 2025, an estimated $1.77M increase.
  • HighVista Strategies's biggest Q1 2025 reduction was Amazon, cutting an estimated $3.36M.
  • HighVista Strategies fully exited HashiCorp, Inc. Class A Common Stock in Q1 2025, selling an estimated $4.45M.
  • HighVista Strategies's ten largest holdings make up 26% of its $260M portfolio in Q1 2025.
  • HighVista Strategies opened 35 new positions and closed 24 in Q1 2025.
  • HighVista Strategies's portfolio value fell 3.5% quarter-over-quarter to $260M.

Based on HighVista Strategies's 13F filing for Q1 2025, filed 15 May 2025.