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HighVista Strategies Portfolio holdings

AUM $439M
1-Year Est. Return 289.78%
This Fund
S&P 500
This Quarter Est. Return
+1.03%
1 Year Est. Return
+289.78%
3 Year Est. Return
+622.25%
5 Year Est. Return
+856.34%
10 Year Est. Return
+2,866.87%
AUM
$269M
AUM Growth
-$21.2M
Cap. Flow
-$10M
Cap. Flow %
-3.73%
Top 10 Hldgs %
26.35%
Holding
168
New
26
Increased
41
Reduced
37
Closed
31

Top Buys

Rank Stock Value
1
META icon
Meta Platforms (Facebook)
META
+$3.11M
2
GH icon
Guardant Health
GH
+$2.65M
3
JANX icon
Janux Therapeutics
JANX
+$2.45M
4
APLS
Apellis Pharmaceuticals
APLS
+$2.19M
5
GEHC icon
GE HealthCare
GEHC
+$1.85M

Top Sells

Rank Stock Value
1
CTLT
CATALENT, INC.
CTLT
+$4.58M
2
CPRI icon
Capri Holdings
CPRI
+$3.3M
3
AMGN icon
Amgen
AMGN
+$3.25M
4
CART icon
Maplebear
CART
+$3.2M
5
GEV icon
GE Vernova
GEV
+$2.47M

Sector Composition

Rank Sector Weight
1 Healthcare 43.86%
2 Technology 16.73%
3 Miscellaneous 11.42%
4 Consumer Discretionary 7.18%
5 Communication Services 5.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
DBC icon
1
Invesco DB Commodity Index Tracking Fund
DBC
$1.97B
$30.7M 11.42%
1,436,136
– –
AMZN icon
2
Amazon
AMZN
$2.68T
$7.5M 2.79%
34,193
+2,000
+6% +$409K
HCP
3
DELISTED
HashiCorp, Inc. Class A Common Stock
HCP
$4.45M 1.66%
130,200
– –
MSFT icon
4
Microsoft
MSFT
$3.67T
$4.45M 1.66%
10,558
+3,300
+45% +$1.41M
ANSS
5
DELISTED
Ansys
ANSS
$4.32M 1.61%
12,800
– –
JNPR
6
DELISTED
Juniper Networks
JNPR
$4.3M 1.6%
114,700
– –
HES
7
DELISTED
Hess
HES
$3.84M 1.43%
28,900
– –
DVAX
8
DELISTED
Dynavax Technologies
DVAX
$3.81M 1.42%
298,536
+135,828
+83% +$1.64M
JANX icon
9
Janux Therapeutics
JANX
$997M
$3.73M 1.39%
69,715
+46,243
+197% +$2.45M
ACI icon
10
Albertsons Companies
ACI
$6.22B
$3.71M 1.38%
188,753
– –
PCVX icon
11
Vaxcyte
PCVX
$8.91B
$3.66M 1.36%
44,661
– –
AMED
12
DELISTED
Amedisys
AMED
$3.56M 1.33%
39,250
– –
ARGX icon
13
argenx
ARGX
$61.3B
$3.53M 1.31%
5,747
-1,407
-20% -$824K
APLS
14
DELISTED
Apellis Pharmaceuticals
APLS
$3.47M 1.29%
108,714
+72,739
+202% +$2.19M
XPO icon
15
XPO
XPO
$20.3B
$3.38M 1.26%
25,780
-11,900
-32% -$1.61M
ACLX
16
DELISTED
Arcellx
ACLX
$3.36M 1.25%
43,804
-11,335
-21% -$979K
BKNG icon
17
Booking.com
BKNG
$130B
$3.26M 1.21%
16,425
+7,500
+84% +$1.44M
CRM icon
18
Salesforce
CRM
$206B
$3.2M 1.19%
9,585
-7,000
-42% -$2.23M
NUVL
19
DELISTED
Nuvalent
NUVL
$3.12M 1.16%
39,876
+10,858
+37% +$1.01M
META icon
20
Meta Platforms (Facebook)
META
$1.73T
$3.1M 1.15%
+5,300
New +$3.11M
XOMA
21
DELISTED
Xoma
XOMA
$3.01M 1.12%
114,548
– –
VRDN icon
22
Viridian Therapeutics
VRDN
$2.48B
$2.96M 1.1%
154,563
-30,677
-17% -$667K
GH icon
23
Guardant Health
GH
$23.8B
$2.88M 1.07%
+94,118
New +$2.65M
GEHC icon
24
GE HealthCare
GEHC
$28.8B
$2.74M 1.02%
35,000
+21,800
+165% +$1.85M
XENE icon
25
Xenon Pharmaceuticals
XENE
$5.57B
$2.62M 0.97%
66,788
-6,974
-9% -$288K
1
2 3 4 5

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HighVista Strategies's Q4 2024 Portfolio in Review

As of Q4 2024, HighVista Strategies held 168 positions worth $269M, down 7.3% from $290M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies withdrew a net $10M in Q4 2024, closing 31 positions and reducing 37 holdings. Its most notable exit was CATALENT, INC., an estimated $4.58M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 44% of assets, down from 46% a quarter earlier, followed by Technology and Miscellaneous.

Against the trend, HighVista Strategies opened a new position in Meta Platforms (Facebook) worth $3.1M.

  • HighVista Strategies's largest Q4 2024 buy was Meta Platforms (Facebook): 5,300 shares worth $3.1M.
  • HighVista Strategies added most to Janux Therapeutics in Q4 2024, an estimated $2.45M increase.
  • HighVista Strategies's biggest Q4 2024 reduction was GE Vernova, cutting an estimated $2.47M.
  • HighVista Strategies fully exited CATALENT, INC. in Q4 2024, selling an estimated $4.58M.
  • HighVista Strategies's ten largest holdings make up 26% of its $269M portfolio in Q4 2024.
  • HighVista Strategies opened 26 new positions and closed 31 in Q4 2024.
  • HighVista Strategies's portfolio value fell 7.3% quarter-over-quarter to $269M.

Based on HighVista Strategies's 13F filing for Q4 2024, filed 14 Feb 2025.