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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+50.91%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$388M
AUM Growth
-$19.7M
Cap. Flow
-$118M
Cap. Flow %
-30.34%
Top 10 Hldgs %
28.14%
Holding
181
New
33
Increased
26
Reduced
86
Closed
36

Top Buys

Rank Stock Value
1
SLNO
Soleno Therapeutics
SLNO
+$6.38M
2
MAZE
Maze Therapeutics
MAZE
+$5.85M
3
TERN
Terns Pharmaceuticals
TERN
+$4.05M
4
PHVS icon
Pharvaris
PHVS
+$3.91M
5
STOK icon
Stoke Therapeutics
STOK
+$3.47M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$12.9M
2
MRUS
Merus
MRUS
+$12.6M
3
ABVX
Abivax
ABVX
+$12.3M
4
SNDK
Sandisk
SNDK
+$8.63M
5
DBC icon
Invesco DB Commodity Index Tracking Fund
DBC
+$8.61M

Sector Composition

Rank Sector Weight
1 Healthcare 69.79%
2 Technology 6.85%
3 Industrials 5.94%
4 Financials 3.09%
5 Consumer Discretionary 2.49%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
VERA icon
176
Vera Therapeutics
VERA
$2.17B
– –
-91,189
Closed -$2.65M
WDC icon
177
Western Digital
WDC
$151B
– –
-14,242
Closed -$1.71M
WVE icon
178
Wave Life Sciences
WVE
$993M
– –
-59,261
Closed -$434K
XENE icon
179
Xenon Pharmaceuticals
XENE
$6.11B
– –
-82,190
Closed -$3.3M
NBIS
180
Nebius Group N.V.
NBIS
$49.1B
– –
-5,200
Closed -$584K
MAGN
181
Magnera Corp
MAGN
$444M
– –
-87,100
Closed -$1.02M
4 5 6 7
8

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HighVista Strategies's Q4 2025 Portfolio in Review

As of Q4 2025, HighVista Strategies held 181 positions worth $388M, down 4.8% from $408M the previous quarter. Its ten largest holdings account for 28% of the portfolio.

HighVista Strategies withdrew a net $118M in Q4 2025, closing 36 positions and reducing 86 holdings. Its most notable exit was Merus, an estimated $12.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 70% of assets, up from 59% a quarter earlier, followed by Technology and Industrials.

Against the trend, HighVista Strategies opened a new position in Maze Therapeutics worth $7.06M.

  • HighVista Strategies's largest Q4 2025 buy was Maze Therapeutics: 170,353 shares worth $7.06M.
  • HighVista Strategies added most to Soleno Therapeutics in Q4 2025, an estimated $6.38M increase.
  • HighVista Strategies's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $12.9M.
  • HighVista Strategies fully exited Merus in Q4 2025, selling an estimated $12.6M.
  • HighVista Strategies's ten largest holdings make up 28% of its $388M portfolio in Q4 2025.
  • HighVista Strategies opened 33 new positions and closed 36 in Q4 2025.
  • HighVista Strategies's portfolio value fell 4.8% quarter-over-quarter to $388M.

Based on HighVista Strategies's 13F filing for Q4 2025, filed 17 Feb 2026.