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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+69.32%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$408M
AUM Growth
+$136M
Cap. Flow
+$68.1M
Cap. Flow %
16.68%
Top 10 Hldgs %
29.1%
Holding
175
New
29
Increased
78
Reduced
38
Closed
27

Top Buys

Rank Stock Value
1
ABVX
Abivax
ABVX
+$8.17M
2
AGIO icon
Agios Pharmaceuticals
AGIO
+$4.71M
3
INSM icon
Insmed
INSM
+$4.7M
4
CDTX
Cidara Therapeutics
CDTX
+$4.52M
5
ACLX
Arcellx
ACLX
+$4.35M

Top Sells

Rank Stock Value
1
ANSS
Ansys
ANSS
+$6.01M
2
JNPR
Juniper Networks
JNPR
+$4.58M
3
HES
Hess
HES
+$4M
4
AMED
Amedisys
AMED
+$3.86M
5
WDC icon
Western Digital
WDC
+$2.97M

Sector Composition

Rank Sector Weight
1 Healthcare 59%
2 Technology 12.01%
3 Industrials 6.97%
4 Financials 4.64%
5 Consumer Discretionary 3.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ANSS
151
DELISTED
Ansys
ANSS
– –
-17,100
Closed -$6.01M
CATX icon
152
Perspective Therapeutics
CATX
$363M
– –
-138,350
Closed -$476K
CGEM icon
153
Cullinan Oncology
CGEM
$1.26B
– –
-31,893
Closed -$240K
CLF icon
154
Cleveland-Cliffs
CLF
$7.08B
– –
-255,600
Closed -$1.94M
CME icon
155
CME Group
CME
$93.2B
– –
-5,200
Closed -$1.43M
DAL icon
156
Delta Air Lines
DAL
$59.5B
– –
-30,800
Closed -$1.51M
DYN icon
157
Dyne Therapeutics
DYN
$4.99B
– –
-26,324
Closed -$251K
ETNB
158
DELISTED
89bio
ETNB
– –
-47,633
Closed -$468K
GERN icon
159
Geron
GERN
$1.05B
– –
-132,711
Closed -$187K
HCA icon
160
HCA Healthcare
HCA
$89.1B
– –
-3,100
Closed -$1.19M
HES
161
DELISTED
Hess
HES
– –
-28,900
Closed -$4M
HUBS icon
162
HubSpot
HUBS
$11B
– –
-1,800
Closed -$1M
IRON icon
163
Disc Medicine
IRON
$3.12B
– –
-6,733
Closed -$357K
JNPR
164
DELISTED
Juniper Networks
JNPR
– –
-114,700
Closed -$4.58M
KGS icon
165
Kodiak Gas Services
KGS
$6.17B
– –
-34,000
Closed -$1.17M
LKQ icon
166
LKQ Corp
LKQ
$6.25B
– –
-29,500
Closed -$1.09M
LYFT icon
167
Lyft
LYFT
$6.64B
– –
-125,800
Closed -$1.98M
PHVS icon
168
Pharvaris
PHVS
$2.41B
– –
-23,739
Closed -$418K
PM icon
169
Philip Morris
PM
$290B
– –
-6,700
Closed -$1.22M
RCL icon
170
Royal Caribbean
RCL
$82.1B
– –
-4,600
Closed -$1.44M
REXR icon
171
Rexford Industrial Realty
REXR
$8.07B
– –
-36,200
Closed -$1.29M
SNPS icon
172
Synopsys
SNPS
$78.7B
– –
-3,900
Closed -$2M
TKO icon
173
TKO Group
TKO
$14.2B
– –
-7,600
Closed -$1.38M
VRNA
174
DELISTED
Verona Pharma
VRNA
– –
-28,880
Closed -$2.73M
XNCR icon
175
Xencor
XNCR
$1.64B
– –
-33,304
Closed -$262K
3 4 5 6
7

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HighVista Strategies's Q3 2025 Portfolio in Review

As of Q3 2025, HighVista Strategies held 175 positions worth $408M, up 50% from $272M the previous quarter. Its ten largest holdings account for 29% of the portfolio.

HighVista Strategies deployed $68.1M of net new capital in Q3 2025, opening 29 new positions and adding to 78 existing holdings. Its largest new stake was Cidara Therapeutics: 70,904 shares worth $6.79M.

By sector, the portfolio is most concentrated in Healthcare at 59% of assets, up from 38% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Western Digital, an estimated $2.97M trimmed.

  • HighVista Strategies's largest Q3 2025 buy was Cidara Therapeutics: 70,904 shares worth $6.79M.
  • HighVista Strategies added most to Abivax in Q3 2025, an estimated $8.17M increase.
  • HighVista Strategies's biggest Q3 2025 reduction was Western Digital, cutting an estimated $2.97M.
  • HighVista Strategies fully exited Ansys in Q3 2025, selling an estimated $6.01M.
  • HighVista Strategies's ten largest holdings make up 29% of its $408M portfolio in Q3 2025.
  • HighVista Strategies opened 29 new positions and closed 27 in Q3 2025.
  • HighVista Strategies's portfolio value rose 50% quarter-over-quarter to $408M.

Based on HighVista Strategies's 13F filing for Q3 2025, filed 14 Nov 2025.