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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+50.91%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$388M
AUM Growth
-$19.7M
Cap. Flow
-$118M
Cap. Flow %
-30.34%
Top 10 Hldgs %
28.14%
Holding
181
New
33
Increased
26
Reduced
86
Closed
36

Top Buys

Rank Stock Value
1
SLNO
Soleno Therapeutics
SLNO
+$6.38M
2
MAZE
Maze Therapeutics
MAZE
+$5.85M
3
TERN
Terns Pharmaceuticals
TERN
+$4.05M
4
PHVS icon
Pharvaris
PHVS
+$3.91M
5
STOK icon
Stoke Therapeutics
STOK
+$3.47M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$12.9M
2
MRUS
Merus
MRUS
+$12.6M
3
ABVX
Abivax
ABVX
+$12.3M
4
SNDK
Sandisk
SNDK
+$8.63M
5
DBC icon
Invesco DB Commodity Index Tracking Fund
DBC
+$8.61M

Sector Composition

Rank Sector Weight
1 Healthcare 69.79%
2 Technology 6.85%
3 Industrials 5.94%
4 Financials 3.09%
5 Consumer Discretionary 2.49%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
GTLB icon
126
GitLab
GTLB
$7.11B
$725K 0.19%
+19,305
New +$836K
EDU icon
127
New Oriental
EDU
$8.84B
$705K 0.18%
+12,817
New +$703K
RBLX icon
128
Roblox
RBLX
$25.9B
$683K 0.18%
8,431
-269
-3% -$28.6K
ALC icon
129
Alcon
ALC
$36.7B
$661K 0.17%
10,440
+2,578
+33% +$198K
URGN icon
130
UroGen Pharma
URGN
$2.3B
$656K 0.17%
28,005
-3,881
-12% -$84.2K
CNX icon
131
CNX Resources
CNX
$5.35B
$648K 0.17%
17,624
-13,676
-44% -$490K
BBD icon
132
Banco Bradesco
BBD
$35B
$634K 0.16%
190,264
-329,836
-63% -$1.12M
MMM icon
133
3M
MMM
$94.4B
$632K 0.16%
3,950
-3,650
-48% -$597K
ALV icon
134
Autoliv
ALV
$8.96B
$622K 0.16%
5,243
-3,457
-40% -$413K
PBR.A icon
135
Petrobras Class A
PBR.A
$103B
$622K 0.16%
55,200
-83,000
-60% -$958K
XEL icon
136
Xcel Energy
XEL
$48.5B
$595K 0.15%
+8,058
New +$636K
AGX icon
137
Argan
AGX
$8.11B
$594K 0.15%
1,896
-5,204
-73% -$1.65M
CPNG icon
138
Coupang
CPNG
$29.7B
$585K 0.15%
24,792
+742
+3% +$21.1K
JANX icon
139
Janux Therapeutics
JANX
$1.01B
$572K 0.15%
41,443
-13,807
-25% -$325K
KYMR icon
140
Kymera Therapeutics
KYMR
$9.11B
$532K 0.14%
6,835
-8,893
-57% -$601K
JD icon
141
JD.com
JD
$43.1B
$501K 0.13%
17,463
-5,920
-25% -$185K
NKTR icon
142
Nektar Therapeutics
NKTR
$2.55B
$497K 0.13%
+11,749
New +$658K
BZ icon
143
Kanzhun
BZ
$7.49B
$420K 0.11%
20,598
+1,698
+9% +$36.7K
NOK icon
144
Nokia
NOK
$52.7B
$385K 0.1%
59,524
-23,376
-28% -$145K
DBVT
145
DBV Technologies
DBVT
$885M
$304K 0.08%
+15,877
New +$248K
ADMA icon
146
ADMA Biologics
ADMA
$2.22B
– –
-95,112
Closed -$1.39M
AKRO
147
DELISTED
Akero Therapeutics
AKRO
– –
-110,079
Closed -$5.23M
AMD icon
148
Advanced Micro Devices
AMD
$774B
– –
-17,200
Closed -$2.78M
AURA icon
149
Aura Biosciences
AURA
$832M
– –
-27,174
Closed -$168K
AVTR icon
150
Avantor
AVTR
$9.31B
– –
-172,400
Closed -$2.15M
4 5
6
7 8

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HighVista Strategies's Q4 2025 Portfolio in Review

As of Q4 2025, HighVista Strategies held 181 positions worth $388M, down 4.8% from $408M the previous quarter. Its ten largest holdings account for 28% of the portfolio.

HighVista Strategies withdrew a net $118M in Q4 2025, closing 36 positions and reducing 86 holdings. Its most notable exit was Merus, an estimated $12.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 70% of assets, up from 59% a quarter earlier, followed by Technology and Industrials.

Against the trend, HighVista Strategies opened a new position in Maze Therapeutics worth $7.06M.

  • HighVista Strategies's largest Q4 2025 buy was Maze Therapeutics: 170,353 shares worth $7.06M.
  • HighVista Strategies added most to Soleno Therapeutics in Q4 2025, an estimated $6.38M increase.
  • HighVista Strategies's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $12.9M.
  • HighVista Strategies fully exited Merus in Q4 2025, selling an estimated $12.6M.
  • HighVista Strategies's ten largest holdings make up 28% of its $388M portfolio in Q4 2025.
  • HighVista Strategies opened 33 new positions and closed 36 in Q4 2025.
  • HighVista Strategies's portfolio value fell 4.8% quarter-over-quarter to $388M.

Based on HighVista Strategies's 13F filing for Q4 2025, filed 17 Feb 2026.