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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
-4.54%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$260M
AUM Growth
-$9.28M
Cap. Flow
+$13.5M
Cap. Flow %
5.19%
Top 10 Hldgs %
25.84%
Holding
172
New
35
Increased
39
Reduced
27
Closed
24

Top Buys

Rank Stock Value
1
PWR icon
Quanta Services
PWR
+$2.34M
2
MTZ icon
MasTec
MTZ
+$2.2M
3
MA icon
Mastercard
MA
+$2.01M
4
IMVT icon
Immunovant
IMVT
+$2M
5
MMM icon
3M
MMM
+$1.98M

Top Sells

Rank Stock Value
1
HCP
HashiCorp, Inc. Class A Common Stock
HCP
+$4.45M
2
AMZN icon
Amazon
AMZN
+$3.36M
3
TEVA icon
Teva Pharmaceuticals
TEVA
+$2.23M
4
LYV icon
Live Nation Entertainment
LYV
+$2.02M
5
GH icon
Guardant Health
GH
+$1.83M

Sector Composition

Rank Sector Weight
1 Healthcare 39.15%
2 Technology 17.75%
3 Industrials 8.61%
4 Consumer Discretionary 6.17%
5 Financials 5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KROS icon
126
Keros Therapeutics
KROS
$211M
$531K 0.2%
52,107
– –
ZYME icon
127
Zymeworks
ZYME
$1.73B
$496K 0.19%
+41,607
New +$567K
RARE icon
128
Ultragenyx Pharmaceutical
RARE
$2.66B
$483K 0.19%
+13,328
New +$554K
JD icon
129
JD.com
JD
$43.1B
$460K 0.18%
11,183
+400
+4% +$16.1K
WVE icon
130
Wave Life Sciences
WVE
$993M
$431K 0.17%
+53,374
New +$584K
MIRM icon
131
Mirum Pharmaceuticals
MIRM
$5.99B
$403K 0.16%
8,942
– –
CRBP icon
132
Corbus Pharmaceuticals
CRBP
$184M
$400K 0.15%
75,292
– –
KALV
133
DELISTED
KalVista Pharmaceuticals
KALV
$384K 0.15%
33,305
– –
PHVS icon
134
Pharvaris
PHVS
$2.41B
$357K 0.14%
22,768
– –
XNCR icon
135
Xencor
XNCR
$1.64B
$340K 0.13%
31,942
– –
SRPT icon
136
Sarepta Therapeutics
SRPT
$1.92B
$333K 0.13%
+5,212
New +$549K
IRON icon
137
Disc Medicine
IRON
$3.12B
$321K 0.12%
6,458
– –
ABVX
138
Abivax
ABVX
$11.1B
$307K 0.12%
49,064
– –
GPCR icon
139
Structure Therapeutics
GPCR
$3.71B
$304K 0.12%
17,561
– –
CATX icon
140
Perspective Therapeutics
CATX
$363M
$295K 0.11%
138,350
– –
ARVN icon
141
Arvinas
ARVN
$588M
$290K 0.11%
41,271
-16,730
-29% -$262K
CGEM icon
142
Cullinan Oncology
CGEM
$1.26B
$241K 0.09%
31,893
– –
KYMR icon
143
Kymera Therapeutics
KYMR
$9.11B
$239K 0.09%
8,733
– –
BZ icon
144
Kanzhun
BZ
$7.49B
$228K 0.09%
+11,900
New +$194K
TYRA icon
145
Tyra Biosciences
TYRA
$1.5B
$223K 0.09%
23,941
– –
GERN icon
146
Geron
GERN
$1.05B
$202K 0.08%
127,284
– –
ERAS icon
147
Erasca
ERAS
$6.36B
$186K 0.07%
135,667
– –
PLRX icon
148
Pliant Therapeutics
PLRX
$63.8M
$148K 0.06%
+109,938
New +$667K
ADBE icon
149
Adobe
ADBE
$105B
– –
-2,700
Closed -$1.2M
AUTL
150
Autolus Therapeutics
AUTL
$620M
– –
-533,024
Closed -$1.25M
3 4 5
6
7

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A6
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ACM
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PPG
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PWC
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HighVista Strategies's Q1 2025 Portfolio in Review

As of Q1 2025, HighVista Strategies held 172 positions worth $260M, down 3.5% from $269M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies deployed $13.5M of net new capital in Q1 2025, opening 35 new positions and adding to 39 existing holdings. Its largest new stake was Quanta Services: 8,100 shares worth $2.06M.

By sector, the portfolio is most concentrated in Healthcare at 39% of assets, down from 44% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Amazon, an estimated $3.36M trimmed.

  • HighVista Strategies's largest Q1 2025 buy was Quanta Services: 8,100 shares worth $2.06M.
  • HighVista Strategies added most to Praxis Precision Medicines in Q1 2025, an estimated $1.77M increase.
  • HighVista Strategies's biggest Q1 2025 reduction was Amazon, cutting an estimated $3.36M.
  • HighVista Strategies fully exited HashiCorp, Inc. Class A Common Stock in Q1 2025, selling an estimated $4.45M.
  • HighVista Strategies's ten largest holdings make up 26% of its $260M portfolio in Q1 2025.
  • HighVista Strategies opened 35 new positions and closed 24 in Q1 2025.
  • HighVista Strategies's portfolio value fell 3.5% quarter-over-quarter to $260M.

Based on HighVista Strategies's 13F filing for Q1 2025, filed 15 May 2025.