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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+1.03%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$269M
AUM Growth
-$21.2M
Cap. Flow
-$10M
Cap. Flow %
-3.73%
Top 10 Hldgs %
26.35%
Holding
168
New
26
Increased
41
Reduced
37
Closed
31

Top Buys

Rank Stock Value
1
META icon
Meta Platforms (Facebook)
META
+$3.11M
2
GH icon
Guardant Health
GH
+$2.65M
3
JANX icon
Janux Therapeutics
JANX
+$2.45M
4
APLS
Apellis Pharmaceuticals
APLS
+$2.19M
5
GEHC icon
GE HealthCare
GEHC
+$1.85M

Top Sells

Rank Stock Value
1
CTLT
CATALENT, INC.
CTLT
+$4.58M
2
CPRI icon
Capri Holdings
CPRI
+$3.3M
3
AMGN icon
Amgen
AMGN
+$3.25M
4
CART icon
Maplebear
CART
+$3.2M
5
GEV icon
GE Vernova
GEV
+$2.47M

Sector Composition

Rank Sector Weight
1 Healthcare 43.86%
2 Technology 16.73%
3 Consumer Discretionary 7.18%
4 Communication Services 5.42%
5 Industrials 4.96%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PHVS icon
126
Pharvaris
PHVS
$2.41B
$436K 0.16%
22,768
– –
IRON icon
127
Disc Medicine
IRON
$3.12B
$409K 0.15%
6,458
-3,107
-32% -$180K
KURA icon
128
Kura Oncology
KURA
$882M
$402K 0.15%
46,181
+25,020
+118% +$360K
CGEM icon
129
Cullinan Oncology
CGEM
$1.26B
$388K 0.14%
31,893
– –
JD icon
130
JD.com
JD
$43.1B
$374K 0.14%
10,783
-3,500
-25% -$135K
MIRM icon
131
Mirum Pharmaceuticals
MIRM
$5.99B
$370K 0.14%
8,942
-4,629
-34% -$193K
ABVX
132
Abivax
ABVX
$11.1B
$359K 0.13%
49,064
– –
KYMR icon
133
Kymera Therapeutics
KYMR
$9.11B
$351K 0.13%
8,733
-4,010
-31% -$181K
AKRO
134
DELISTED
Akero Therapeutics
AKRO
$349K 0.13%
+12,529
New +$379K
ERAS icon
135
Erasca
ERAS
$6.36B
$341K 0.13%
+135,667
New +$372K
TYRA icon
136
Tyra Biosciences
TYRA
$1.5B
$333K 0.12%
23,941
+7,863
+49% +$143K
KALV
137
DELISTED
KalVista Pharmaceuticals
KALV
$282K 0.1%
33,305
– –
ACAD icon
138
Acadia Pharmaceuticals
ACAD
$5.07B
– –
-25,287
Closed -$389K
ADSK icon
139
Autodesk
ADSK
$53.1B
– –
-7,500
Closed -$2.07M
AER icon
140
AerCap
AER
$23.5B
– –
-17,000
Closed -$1.61M
ALNY icon
141
Alnylam Pharmaceuticals
ALNY
$29.6B
– –
-1,551
Closed -$427K
ALV icon
142
Autoliv
ALV
$8.96B
– –
-7,200
Closed -$672K
AMGN icon
143
Amgen
AMGN
$224B
– –
-10,101
Closed -$3.25M
ANAB icon
144
AnaptysBio
ANAB
$1.71B
– –
-15,574
Closed -$522K
BEKE icon
145
KE Holdings
BEKE
$18.7B
– –
-30,507
Closed -$607K
BIDU icon
146
Baidu
BIDU
$35.9B
– –
-5,386
Closed -$567K
CART icon
147
Maplebear
CART
$11.4B
– –
-78,500
Closed -$3.2M
CLDX icon
148
Celldex Therapeutics
CLDX
$3.48B
– –
-8,981
Closed -$305K
CPRI icon
149
Capri Holdings
CPRI
$1.77B
– –
-77,700
Closed -$3.3M
CRH icon
150
CRH
CRH
$67.4B
– –
-11,100
Closed -$1.03M
3 4 5
6
7

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HighVista Strategies's Q4 2024 Portfolio in Review

As of Q4 2024, HighVista Strategies held 168 positions worth $269M, down 7.3% from $290M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies withdrew a net $10M in Q4 2024, closing 31 positions and reducing 37 holdings. Its most notable exit was CATALENT, INC., an estimated $4.58M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 44% of assets, down from 46% a quarter earlier, followed by Technology and Consumer Discretionary.

Against the trend, HighVista Strategies opened a new position in Meta Platforms (Facebook) worth $3.1M.

  • HighVista Strategies's largest Q4 2024 buy was Meta Platforms (Facebook): 5,300 shares worth $3.1M.
  • HighVista Strategies added most to Janux Therapeutics in Q4 2024, an estimated $2.45M increase.
  • HighVista Strategies's biggest Q4 2024 reduction was GE Vernova, cutting an estimated $2.47M.
  • HighVista Strategies fully exited CATALENT, INC. in Q4 2024, selling an estimated $4.58M.
  • HighVista Strategies's ten largest holdings make up 26% of its $269M portfolio in Q4 2024.
  • HighVista Strategies opened 26 new positions and closed 31 in Q4 2024.
  • HighVista Strategies's portfolio value fell 7.3% quarter-over-quarter to $269M.

Based on HighVista Strategies's 13F filing for Q4 2024, filed 14 Feb 2025.