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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+50.91%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$388M
AUM Growth
-$19.7M
Cap. Flow
-$118M
Cap. Flow %
-30.34%
Top 10 Hldgs %
28.14%
Holding
181
New
33
Increased
26
Reduced
86
Closed
36

Top Buys

Rank Stock Value
1
SLNO
Soleno Therapeutics
SLNO
+$6.38M
2
MAZE
Maze Therapeutics
MAZE
+$5.85M
3
TERN
Terns Pharmaceuticals
TERN
+$4.05M
4
PHVS icon
Pharvaris
PHVS
+$3.91M
5
STOK icon
Stoke Therapeutics
STOK
+$3.47M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$12.9M
2
MRUS
Merus
MRUS
+$12.6M
3
ABVX
Abivax
ABVX
+$12.3M
4
SNDK
Sandisk
SNDK
+$8.63M
5
DBC icon
Invesco DB Commodity Index Tracking Fund
DBC
+$8.61M

Sector Composition

Rank Sector Weight
1 Healthcare 69.79%
2 Technology 6.85%
3 Industrials 5.94%
4 Financials 3.09%
5 Consumer Discretionary 2.49%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
CNTA
101
DELISTED
Centessa Pharmaceuticals
CNTA
$1.11M 0.29%
44,490
-18,811
-30% -$476K
PTC icon
102
PTC
PTC
$16.3B
$1.11M 0.29%
6,374
-3,148
-33% -$585K
MTZ icon
103
MasTec
MTZ
$21.8B
$1.09M 0.28%
5,027
-1,673
-25% -$351K
SCHW
104
Charles Schwab
SCHW
$186B
$1.06M 0.27%
10,601
-3,499
-25% -$332K
NU icon
105
Nu Holdings
NU
$65.9B
$1.05M 0.27%
62,570
-46,767
-43% -$752K
SNDK
106
Sandisk
SNDK
$186B
$1.04M 0.27%
4,378
-43,073
-91% -$8.63M
PFSI icon
107
PennyMac Financial
PFSI
$3.98B
$1.03M 0.27%
7,806
-531
-6% -$67.7K
AFRM icon
108
Affirm
AFRM
$25.7B
$974K 0.25%
13,086
+586
+5% +$42.2K
CAAP icon
109
Corporacion America
CAAP
$4.03B
$966K 0.25%
37,145
-34,255
-48% -$767K
APH icon
110
Amphenol
APH
$206B
$957K 0.25%
7,081
-8,319
-54% -$1.11M
ETR icon
111
Entergy
ETR
$49.6B
$955K 0.25%
10,328
+728
+8% +$69.1K
SE icon
112
Sea Limited
SE
$80.6B
$950K 0.24%
7,450
+2,309
+45% +$342K
YMM icon
113
Full Truck Alliance
YMM
$9.67B
$940K 0.24%
+87,591
New +$1.05M
MELI icon
114
Mercado Libre
MELI
$98.3B
$937K 0.24%
465
-35
-7% -$73.5K
CORZ icon
115
Core Scientific
CORZ
$6.36B
$925K 0.24%
63,512
-11,651
-16% -$203K
TYRA icon
116
Tyra Biosciences
TYRA
$1.5B
$922K 0.24%
35,086
-30,726
-47% -$564K
VST icon
117
Vistra
VST
$48.6B
$915K 0.24%
+5,673
New +$1.03M
CTMX icon
118
CytomX Therapeutics
CTMX
$750M
$826K 0.21%
193,941
-63,207
-25% -$240K
BVN icon
119
Compañía de Minas Buenaventura
BVN
$8.82B
$825K 0.21%
29,649
-53,282
-64% -$1.33M
FOUR icon
120
Shift4
FOUR
$3.25B
$817K 0.21%
12,982
+482
+4% +$34.1K
HDB icon
121
HDFC Bank
HDB
$120B
$809K 0.21%
22,127
-10,555
-32% -$380K
IBN icon
122
ICICI Bank
IBN
$107B
$783K 0.2%
26,284
-10,763
-29% -$330K
ASND icon
123
Ascendis Pharma A/S
ASND
$16.7B
$780K 0.2%
3,660
-3,422
-48% -$707K
TCOM icon
124
Trip.com Group
TCOM
$29.1B
$766K 0.2%
10,646
+890
+9% +$63.6K
ALKS icon
125
Alkermes
ALKS
$8.27B
$739K 0.19%
26,401
-17,680
-40% -$530K
3 4
5
6 7

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HighVista Strategies's Q4 2025 Portfolio in Review

As of Q4 2025, HighVista Strategies held 181 positions worth $388M, down 4.8% from $408M the previous quarter. Its ten largest holdings account for 28% of the portfolio.

HighVista Strategies withdrew a net $118M in Q4 2025, closing 36 positions and reducing 86 holdings. Its most notable exit was Merus, an estimated $12.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 70% of assets, up from 59% a quarter earlier, followed by Technology and Industrials.

Against the trend, HighVista Strategies opened a new position in Maze Therapeutics worth $7.06M.

  • HighVista Strategies's largest Q4 2025 buy was Maze Therapeutics: 170,353 shares worth $7.06M.
  • HighVista Strategies added most to Soleno Therapeutics in Q4 2025, an estimated $6.38M increase.
  • HighVista Strategies's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $12.9M.
  • HighVista Strategies fully exited Merus in Q4 2025, selling an estimated $12.6M.
  • HighVista Strategies's ten largest holdings make up 28% of its $388M portfolio in Q4 2025.
  • HighVista Strategies opened 33 new positions and closed 36 in Q4 2025.
  • HighVista Strategies's portfolio value fell 4.8% quarter-over-quarter to $388M.

Based on HighVista Strategies's 13F filing for Q4 2025, filed 17 Feb 2026.