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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+69.32%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$408M
AUM Growth
+$136M
Cap. Flow
+$68.1M
Cap. Flow %
16.68%
Top 10 Hldgs %
29.1%
Holding
175
New
29
Increased
78
Reduced
38
Closed
27

Top Buys

Rank Stock Value
1
ABVX
Abivax
ABVX
+$8.17M
2
AGIO icon
Agios Pharmaceuticals
AGIO
+$4.71M
3
INSM icon
Insmed
INSM
+$4.7M
4
CDTX
Cidara Therapeutics
CDTX
+$4.52M
5
ACLX
Arcellx
ACLX
+$4.35M

Top Sells

Rank Stock Value
1
ANSS
Ansys
ANSS
+$6.01M
2
JNPR
Juniper Networks
JNPR
+$4.58M
3
HES
Hess
HES
+$4M
4
AMED
Amedisys
AMED
+$3.86M
5
WDC icon
Western Digital
WDC
+$2.97M

Sector Composition

Rank Sector Weight
1 Healthcare 59%
2 Technology 12.01%
3 Industrials 6.97%
4 Financials 4.64%
5 Consumer Discretionary 3.42%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
KROS icon
101
Keros Therapeutics
KROS
$211M
$1.31M 0.32%
83,050
+30,432
+58% +$450K
CAAP icon
102
Corporacion America
CAAP
$4.03B
$1.29M 0.32%
71,400
+9,400
+15% +$189K
SLNO
103
DELISTED
Soleno Therapeutics
SLNO
$1.26M 0.31%
18,700
+5,759
+45% +$427K
RLAY icon
104
Relay Therapeutics
RLAY
$4.38B
$1.26M 0.31%
240,459
+90,758
+61% +$346K
OCUL icon
105
Ocular Therapeutix
OCUL
$2.14B
$1.25M 0.31%
106,611
+17,735
+20% +$212K
RXO icon
106
RXO
RXO
$3.54B
$1.24M 0.31%
80,900
+3,800
+5% +$61.3K
JCI icon
107
Johnson Controls International
JCI
$93.7B
$1.22M 0.3%
+11,100
New +$1.19M
RBLX icon
108
Roblox
RBLX
$25.9B
$1.21M 0.3%
+8,700
New +$1.08M
NEE icon
109
NextEra Energy
NEE
$179B
$1.19M 0.29%
+15,752
New +$1.15M
MMM icon
110
3M
MMM
$94.4B
$1.18M 0.29%
7,600
-6,800
-47% -$1.05M
MELI icon
111
Mercado Libre
MELI
$98.4B
$1.17M 0.29%
+500
New +$1.2M
CZR icon
112
Caesars Entertainment
CZR
$6.06B
$1.16M 0.28%
+43,000
New +$1.16M
AXSM icon
113
Axsome Therapeutics
AXSM
$11.1B
$1.14M 0.28%
9,348
-1,561
-14% -$176K
IBN icon
114
ICICI Bank
IBN
$107B
$1.12M 0.27%
37,047
+8,000
+28% +$261K
HDB icon
115
HDFC Bank
HDB
$120B
$1.12M 0.27%
32,682
+6,200
+23% +$229K
ALV icon
116
Autoliv
ALV
$8.96B
$1.07M 0.26%
8,700
+200
+2% +$23.9K
NTRA icon
117
Natera
NTRA
$45.1B
$1.06M 0.26%
6,580
+2,566
+64% +$406K
CGON icon
118
CG Oncology
CGON
$6.83B
$1.05M 0.26%
26,040
+15,712
+152% +$457K
PFSI icon
119
PennyMac Financial
PFSI
$3.98B
$1.03M 0.25%
8,337
-4,200
-34% -$454K
MAGN
120
Magnera Corp
MAGN
$444M
$1.02M 0.25%
87,100
-12,600
-13% -$156K
GEV icon
121
GE Vernova
GEV
$269B
$1.01M 0.25%
1,650
-2,350
-59% -$1.42M
CNX icon
122
CNX Resources
CNX
$5.35B
$1.01M 0.25%
31,300
-5,800
-16% -$178K
FOUR icon
123
Shift4
FOUR
$3.24B
$968K 0.24%
12,500
+1,200
+11% +$112K
TYRA icon
124
Tyra Biosciences
TYRA
$1.5B
$921K 0.23%
65,812
+40,850
+164% +$466K
SE icon
125
Sea Limited
SE
$80.5B
$919K 0.23%
5,141
-3,800
-43% -$651K
3 4
5
6 7

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HighVista Strategies's Q3 2025 Portfolio in Review

As of Q3 2025, HighVista Strategies held 175 positions worth $408M, up 50% from $272M the previous quarter. Its ten largest holdings account for 29% of the portfolio.

HighVista Strategies deployed $68.1M of net new capital in Q3 2025, opening 29 new positions and adding to 78 existing holdings. Its largest new stake was Cidara Therapeutics: 70,904 shares worth $6.79M.

By sector, the portfolio is most concentrated in Healthcare at 59% of assets, up from 38% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Western Digital, an estimated $2.97M trimmed.

  • HighVista Strategies's largest Q3 2025 buy was Cidara Therapeutics: 70,904 shares worth $6.79M.
  • HighVista Strategies added most to Abivax in Q3 2025, an estimated $8.17M increase.
  • HighVista Strategies's biggest Q3 2025 reduction was Western Digital, cutting an estimated $2.97M.
  • HighVista Strategies fully exited Ansys in Q3 2025, selling an estimated $6.01M.
  • HighVista Strategies's ten largest holdings make up 29% of its $408M portfolio in Q3 2025.
  • HighVista Strategies opened 29 new positions and closed 27 in Q3 2025.
  • HighVista Strategies's portfolio value rose 50% quarter-over-quarter to $408M.

Based on HighVista Strategies's 13F filing for Q3 2025, filed 14 Nov 2025.