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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
-4.54%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$260M
AUM Growth
-$9.28M
Cap. Flow
+$13.5M
Cap. Flow %
5.19%
Top 10 Hldgs %
25.84%
Holding
172
New
35
Increased
39
Reduced
27
Closed
24

Top Buys

Rank Stock Value
1
PWR icon
Quanta Services
PWR
+$2.34M
2
MTZ icon
MasTec
MTZ
+$2.2M
3
MA icon
Mastercard
MA
+$2.01M
4
IMVT icon
Immunovant
IMVT
+$2M
5
MMM icon
3M
MMM
+$1.98M

Top Sells

Rank Stock Value
1
HCP
HashiCorp, Inc. Class A Common Stock
HCP
+$4.45M
2
AMZN icon
Amazon
AMZN
+$3.36M
3
TEVA icon
Teva Pharmaceuticals
TEVA
+$2.23M
4
LYV icon
Live Nation Entertainment
LYV
+$2.02M
5
GH icon
Guardant Health
GH
+$1.83M

Sector Composition

Rank Sector Weight
1 Healthcare 39.15%
2 Technology 17.75%
3 Industrials 8.61%
4 Consumer Discretionary 6.17%
5 Financials 5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ROIV icon
101
Roivant Sciences
ROIV
$25.5B
$1.16M 0.45%
115,326
– –
PBR.A icon
102
Petrobras Class A
PBR.A
$103B
$1.16M 0.45%
+89,000
New +$1.12M
BBD icon
103
Banco Bradesco
BBD
$35B
$1.15M 0.44%
517,000
-215,200
-29% -$446K
CAAP icon
104
Corporacion America
CAAP
$4.03B
$1.1M 0.42%
+60,200
New +$1.14M
RBC icon
105
RBC Bearings
RBC
$17.5B
$1.09M 0.42%
+3,400
New +$1.15M
VRNA
106
DELISTED
Verona Pharma
VRNA
$1.06M 0.41%
16,701
-7,038
-30% -$421K
CPNG icon
107
Coupang
CPNG
$29.7B
$1.04M 0.4%
47,500
-22,200
-32% -$516K
HUBS icon
108
HubSpot
HUBS
$11B
$1.03M 0.4%
+1,800
New +$1.26M
SLNO
109
DELISTED
Soleno Therapeutics
SLNO
$1.02M 0.39%
14,344
– –
NU icon
110
Nu Holdings
NU
$65.9B
$1.02M 0.39%
99,737
-25,324
-20% -$299K
SRRK icon
111
Scholar Rock
SRRK
$6.34B
$1M 0.39%
+31,230
New +$1.2M
BABA icon
112
Alibaba
BABA
$306B
$986K 0.38%
7,457
-13,400
-64% -$1.55M
AKRO
113
DELISTED
Akero Therapeutics
AKRO
$974K 0.38%
24,067
+11,538
+92% +$489K
CRNX icon
114
Crinetics Pharmaceuticals
CRNX
$8.95B
$970K 0.37%
28,911
– –
ASND icon
115
Ascendis Pharma A/S
ASND
$16.7B
$946K 0.36%
6,072
– –
DYN icon
116
Dyne Therapeutics
DYN
$4.99B
$820K 0.32%
78,420
– –
OLMA icon
117
Olema Pharmaceuticals
OLMA
$911M
$798K 0.31%
212,185
– –
TCOM icon
118
Trip.com Group
TCOM
$29.1B
$792K 0.31%
12,456
+2,100
+20% +$137K
MDGL icon
119
Madrigal Pharmaceuticals
MDGL
$12.4B
$732K 0.28%
2,211
– –
OCUL icon
120
Ocular Therapeutix
OCUL
$2.14B
$625K 0.24%
85,241
– –
DNTH icon
121
Dianthus Therapeutics
DNTH
$6.07B
$569K 0.22%
31,387
– –
ACN icon
122
Accenture
ACN
$110B
$562K 0.22%
+1,800
New +$636K
CNTA
123
DELISTED
Centessa Pharmaceuticals
CNTA
$561K 0.22%
39,020
-7,096
-15% -$116K
CGON icon
124
CG Oncology
CGON
$6.83B
$546K 0.21%
22,305
– –
NTRA icon
125
Natera
NTRA
$45.1B
$544K 0.21%
3,850
-978
-20% -$157K
3 4
5
6 7

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PWC
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HighVista Strategies's Q1 2025 Portfolio in Review

As of Q1 2025, HighVista Strategies held 172 positions worth $260M, down 3.5% from $269M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies deployed $13.5M of net new capital in Q1 2025, opening 35 new positions and adding to 39 existing holdings. Its largest new stake was Quanta Services: 8,100 shares worth $2.06M.

By sector, the portfolio is most concentrated in Healthcare at 39% of assets, down from 44% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Amazon, an estimated $3.36M trimmed.

  • HighVista Strategies's largest Q1 2025 buy was Quanta Services: 8,100 shares worth $2.06M.
  • HighVista Strategies added most to Praxis Precision Medicines in Q1 2025, an estimated $1.77M increase.
  • HighVista Strategies's biggest Q1 2025 reduction was Amazon, cutting an estimated $3.36M.
  • HighVista Strategies fully exited HashiCorp, Inc. Class A Common Stock in Q1 2025, selling an estimated $4.45M.
  • HighVista Strategies's ten largest holdings make up 26% of its $260M portfolio in Q1 2025.
  • HighVista Strategies opened 35 new positions and closed 24 in Q1 2025.
  • HighVista Strategies's portfolio value fell 3.5% quarter-over-quarter to $260M.

Based on HighVista Strategies's 13F filing for Q1 2025, filed 15 May 2025.