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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+50.91%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$388M
AUM Growth
-$19.7M
Cap. Flow
-$118M
Cap. Flow %
-30.34%
Top 10 Hldgs %
28.14%
Holding
181
New
33
Increased
26
Reduced
86
Closed
36

Top Buys

Rank Stock Value
1
SLNO
Soleno Therapeutics
SLNO
+$6.38M
2
MAZE
Maze Therapeutics
MAZE
+$5.85M
3
TERN
Terns Pharmaceuticals
TERN
+$4.05M
4
PHVS icon
Pharvaris
PHVS
+$3.91M
5
STOK icon
Stoke Therapeutics
STOK
+$3.47M

Top Sells

Rank Stock Value
1
PRAX icon
Praxis Precision Medicines
PRAX
+$12.9M
2
MRUS
Merus
MRUS
+$12.6M
3
ABVX
Abivax
ABVX
+$12.3M
4
SNDK
Sandisk
SNDK
+$8.63M
5
DBC icon
Invesco DB Commodity Index Tracking Fund
DBC
+$8.61M

Sector Composition

Rank Sector Weight
1 Healthcare 69.79%
2 Technology 6.85%
3 Industrials 5.94%
4 Financials 3.09%
5 Consumer Discretionary 2.49%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
AXSM icon
51
Axsome Therapeutics
AXSM
$11.1B
$2.03M 0.52%
11,131
+1,783
+19% +$249K
DNTH icon
52
Dianthus Therapeutics
DNTH
$6.07B
$2M 0.51%
48,484
-5,741
-11% -$223K
GOOG icon
53
Alphabet (Google) Class C
GOOG
$4.19T
$1.97M 0.51%
6,277
-3,523
-36% -$1.01M
AVGO icon
54
Broadcom
AVGO
$1.98T
$1.95M 0.5%
5,639
-4,561
-45% -$1.63M
RKT icon
55
Rocket Companies
RKT
$40.5B
$1.89M 0.49%
+97,430
New +$1.74M
UNP icon
56
Union Pacific
UNP
$174B
$1.86M 0.48%
+8,058
New +$1.84M
HPE icon
57
Hewlett Packard
HPE
$72B
$1.83M 0.47%
76,181
-22,519
-23% -$531K
AMRZ
58
Amrize Ltd
AMRZ
$26.3B
$1.81M 0.47%
+33,468
New +$1.71M
AVTX icon
59
Avalo Therapeutics
AVTX
$1.04B
$1.74M 0.45%
95,631
+67,853
+244% +$1.15M
FLS icon
60
Flowserve
FLS
$10.3B
$1.73M 0.45%
24,958
-14,017
-36% -$901K
XPO icon
61
XPO
XPO
$23.8B
$1.73M 0.45%
12,723
-8,357
-40% -$1.14M
CEG icon
62
Constellation Energy
CEG
$98.6B
$1.7M 0.44%
4,812
-2,788
-37% -$1.01M
META icon
63
Meta Platforms (Facebook)
META
$1.53T
$1.69M 0.44%
2,562
-1,938
-43% -$1.29M
APP icon
64
Applovin
APP
$107B
$1.67M 0.43%
+2,482
New +$1.56M
MDGL icon
65
Madrigal Pharmaceuticals
MDGL
$12.4B
$1.65M 0.43%
2,839
-698
-20% -$357K
CELC icon
66
Celcuity
CELC
$4.3B
$1.65M 0.42%
16,543
+2,863
+21% +$235K
LITE icon
67
Lumentum
LITE
$63.8B
$1.59M 0.41%
4,317
-8,610
-67% -$2.21M
MA icon
68
Mastercard
MA
$492B
$1.59M 0.41%
2,784
-1,421
-34% -$794K
CLF icon
69
Cleveland-Cliffs
CLF
$7.08B
$1.57M 0.41%
+118,574
New +$1.5M
FERG icon
70
Ferguson
FERG
$48.8B
$1.55M 0.4%
6,973
-2,705
-28% -$646K
NEE icon
71
NextEra Energy
NEE
$179B
$1.55M 0.4%
19,285
+3,533
+22% +$293K
UNF icon
72
Unifirst Corp
UNF
$5.27B
$1.49M 0.38%
+7,727
New +$1.3M
CLH icon
73
Clean Harbors
CLH
$16.4B
$1.46M 0.38%
6,243
-2,863
-31% -$654K
EQT icon
74
EQT Corp
EQT
$34B
$1.45M 0.37%
+27,090
New +$1.52M
CLDX icon
75
Celldex Therapeutics
CLDX
$3.48B
$1.41M 0.36%
51,805
-83,453
-62% -$2.2M
1 2
3
4 5

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HighVista Strategies's Q4 2025 Portfolio in Review

As of Q4 2025, HighVista Strategies held 181 positions worth $388M, down 4.8% from $408M the previous quarter. Its ten largest holdings account for 28% of the portfolio.

HighVista Strategies withdrew a net $118M in Q4 2025, closing 36 positions and reducing 86 holdings. Its most notable exit was Merus, an estimated $12.6M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 70% of assets, up from 59% a quarter earlier, followed by Technology and Industrials.

Against the trend, HighVista Strategies opened a new position in Maze Therapeutics worth $7.06M.

  • HighVista Strategies's largest Q4 2025 buy was Maze Therapeutics: 170,353 shares worth $7.06M.
  • HighVista Strategies added most to Soleno Therapeutics in Q4 2025, an estimated $6.38M increase.
  • HighVista Strategies's biggest Q4 2025 reduction was Praxis Precision Medicines, cutting an estimated $12.9M.
  • HighVista Strategies fully exited Merus in Q4 2025, selling an estimated $12.6M.
  • HighVista Strategies's ten largest holdings make up 28% of its $388M portfolio in Q4 2025.
  • HighVista Strategies opened 33 new positions and closed 36 in Q4 2025.
  • HighVista Strategies's portfolio value fell 4.8% quarter-over-quarter to $388M.

Based on HighVista Strategies's 13F filing for Q4 2025, filed 17 Feb 2026.