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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+13.28%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$168M
AUM Growth
-$6.63M
Cap. Flow
-$14M
Cap. Flow %
-8.3%
Top 10 Hldgs %
40.66%
Holding
139
New
26
Increased
28
Reduced
31
Closed
34

Top Buys

Rank Stock Value
1
SJI
South Jersey Industries, Inc.
SJI
+$2.75M
2
AXSM icon
Axsome Therapeutics
AXSM
+$2.29M
3
THRD
Third Harmonic Bio
THRD
+$1.54M
4
ISEE
IVERIC bio, Inc. Common Stock
ISEE
+$1.37M
5
DICE
DICE Therapeutics, Inc. Common Stock
DICE
+$1.27M

Top Sells

Rank Stock Value
1
CHNG
Change Healthcare Inc. Common Stock
CHNG
+$4.46M
2
CYTK icon
Cytokinetics
CYTK
+$3.54M
3
CTXS
Citrix Systems Inc
CTXS
+$3.26M
4
NLSN
Nielsen Holdings plc
NLSN
+$3.17M
5
TWTR
Twitter, Inc.
TWTR
+$2.81M

Sector Composition

Rank Sector Weight
1 Healthcare 46.64%
2 Technology 19.92%
3 Financials 17.76%
4 Consumer Discretionary 3.48%
5 Communication Services 2.68%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ACAD icon
51
Acadia Pharmaceuticals
ACAD
$5.07B
$901K 0.54%
56,618
+3,300
+6% +$51.6K
ASND icon
52
Ascendis Pharma A/S
ASND
$16.7B
$896K 0.53%
7,338
-2,442
-25% -$284K
KROS icon
53
Keros Therapeutics
KROS
$210M
$894K 0.53%
+18,616
New +$870K
UTHR icon
54
United Therapeutics
UTHR
$22.4B
$891K 0.53%
3,204
-662
-17% -$167K
ARGX icon
55
argenx
ARGX
$54B
$884K 0.52%
2,333
+15
+0.6% +$5.61K
PRTA icon
56
Prothena Corp
PRTA
$468M
$878K 0.52%
+14,572
New +$853K
KRYS icon
57
Krystal Biotech
KRYS
$9.66B
$876K 0.52%
11,058
+4,023
+57% +$299K
INCY icon
58
Incyte
INCY
$24.5B
$874K 0.52%
10,879
+5,831
+116% +$446K
MSFT icon
59
Microsoft
MSFT
$3.73T
$844K 0.5%
3,520
-468
-12% -$112K
CGEM icon
60
Cullinan Oncology
CGEM
$1.26B
$843K 0.5%
79,918
– –
SGEN
61
DELISTED
Seagen Inc. Common Stock
SGEN
$829K 0.49%
6,448
+770
+14% +$99.4K
LEGN icon
62
Legend Biotech
LEGN
$4.19B
$809K 0.48%
+16,212
New +$785K
PLRX icon
63
Pliant Therapeutics
PLRX
$65M
$801K 0.48%
+41,462
New +$867K
TERN
64
DELISTED
Terns Pharmaceuticals
TERN
$787K 0.47%
77,344
– –
BIIB icon
65
Biogen
BIIB
$30.4B
$760K 0.45%
+2,743
New +$775K
IMCR icon
66
Immunocore
IMCR
$1.74B
$753K 0.45%
13,194
-3,394
-20% -$191K
BLU
67
DELISTED
BELLUS Health Inc.
BLU
$752K 0.45%
91,493
+14,649
+19% +$137K
VERV
68
DELISTED
Verve Therapeutics
VERV
$689K 0.41%
+35,600
New +$943K
GHRS icon
69
GH Research
GHRS
$2.05B
$638K 0.38%
65,597
+8,828
+16% +$95.5K
AMRN
70
Amarin Corp
AMRN
$297M
$606K 0.36%
25,034
– –
ARVN icon
71
Arvinas
ARVN
$585M
$547K 0.32%
15,994
-2,262
-12% -$95.2K
GBIO
72
DELISTED
Generation Bio
GBIO
$546K 0.32%
13,888
-11,011
-44% -$578K
MRTX
73
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$530K 0.31%
11,703
+892
+8% +$57.7K
GOOG icon
74
Alphabet (Google) Class C
GOOG
$4.22T
$530K 0.31%
5,970
-1,502
-20% -$143K
TDG icon
75
TransDigm Group
TDG
$69.1B
$508K 0.3%
+807
New +$475K
1 2
3
4 5

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HighVista Strategies's Q4 2022 Portfolio in Review

As of Q4 2022, HighVista Strategies held 139 positions worth $168M, down 3.8% from $175M the previous quarter. Its ten largest holdings account for 41% of the portfolio.

HighVista Strategies withdrew a net $14M in Q4 2022, closing 34 positions and reducing 31 holdings. Its most notable exit was Change Healthcare Inc. Common Stock, an estimated $4.46M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 47% of assets, up from 46% a quarter earlier, followed by Technology and Financials.

Against the trend, HighVista Strategies opened a new position in South Jersey Industries, Inc. worth $2.82M.

  • HighVista Strategies's largest Q4 2022 buy was South Jersey Industries, Inc.: 79,500 shares worth $2.82M.
  • HighVista Strategies added most to Axsome Therapeutics in Q4 2022, an estimated $2.29M increase.
  • HighVista Strategies's biggest Q4 2022 reduction was Repare Therapeutics, cutting an estimated $2.08M.
  • HighVista Strategies fully exited Change Healthcare Inc. Common Stock in Q4 2022, selling an estimated $4.46M.
  • HighVista Strategies's ten largest holdings make up 41% of its $168M portfolio in Q4 2022.
  • HighVista Strategies opened 26 new positions and closed 34 in Q4 2022.
  • HighVista Strategies's portfolio value fell 3.8% quarter-over-quarter to $168M.

Based on HighVista Strategies's 13F filing for Q4 2022, filed 14 Feb 2023.