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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+7.61%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$175M
AUM Growth
+$9.44M
Cap. Flow
+$6.42M
Cap. Flow %
3.67%
Top 10 Hldgs %
36.64%
Holding
129
New
19
Increased
30
Reduced
20
Closed
16

Top Buys

Rank Stock Value
1
NLSN
Nielsen Holdings plc
NLSN
+$2.98M
2
BKI
Black Knight, Inc. Common Stock
BKI
+$2.78M
3
VMW
VMware, Inc
VMW
+$2.72M
4
RPTX
Repare Therapeutics
RPTX
+$1.95M
5
COGT icon
Cogent Biosciences
COGT
+$1.63M

Top Sells

Rank Stock Value
1
COHR
Coherent Inc
COHR
+$3.62M
2
TPTX
Turning Point Therapeutics, Inc. Common Stock
TPTX
+$2.96M
3
GBT
Global Blood Therapeutics, Inc.
GBT
+$2.37M
4
IDYA icon
IDEAYA Biosciences
IDYA
+$1.8M
5
DYN icon
Dyne Therapeutics
DYN
+$1.6M

Sector Composition

Rank Sector Weight
1 Healthcare 46.35%
2 Technology 22.42%
3 Financials 15.33%
4 Communication Services 4.08%
5 Consumer Discretionary 3.37%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
BMRN icon
51
BioMarin Pharmaceuticals
BMRN
$13.5B
$833K 0.48%
9,821
+1,225
+14% +$109K
RVMD icon
52
Revolution Medicines
RVMD
$44.1B
$829K 0.47%
42,056
+21,371
+103% +$470K
ARGX icon
53
argenx
ARGX
$54.1B
$818K 0.47%
2,318
+165
+8% +$61.1K
XENE icon
54
Xenon Pharmaceuticals
XENE
$6.11B
$815K 0.47%
22,572
+137
+0.6% +$4.93K
ARVN icon
55
Arvinas
ARVN
$588M
$812K 0.46%
18,256
+2,570
+16% +$125K
BLU
56
DELISTED
BELLUS Health Inc.
BLU
$811K 0.46%
76,844
+40,480
+111% +$430K
UTHR icon
57
United Therapeutics
UTHR
$22.1B
$809K 0.46%
3,866
+414
+12% +$92.6K
HZNP
58
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$808K 0.46%
13,055
+5,636
+76% +$394K
RGNX icon
59
Regenxbio
RGNX
$703M
$785K 0.45%
29,696
+13,344
+82% +$396K
IMCR icon
60
Immunocore
IMCR
$1.74B
$779K 0.44%
+16,588
New +$791K
SGEN
61
DELISTED
Seagen Inc. Common Stock
SGEN
$777K 0.44%
+5,678
New +$925K
MRTX
62
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$755K 0.43%
10,811
-285
-3% -$21.1K
AXSM icon
63
Axsome Therapeutics
AXSM
$11.1B
$753K 0.43%
+16,886
New +$844K
LKFT
64
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.88B
$746K 0.43%
17,499
+5,698
+48% +$292K
MRUS
65
DELISTED
Merus
MRUS
$741K 0.42%
36,994
-3,487
-9% -$83.2K
TCDA
66
DELISTED
Tricida, Inc. Common Stock
TCDA
$733K 0.42%
69,970
+1,422
+2% +$15.6K
FOLD
67
DELISTED
Amicus Therapeutics
FOLD
$719K 0.41%
68,830
-21,404
-24% -$238K
GOOG icon
68
Alphabet (Google) Class C
GOOG
$4.19T
$718K 0.41%
7,472
+1,552
+26% +$173K
CLDX icon
69
Celldex Therapeutics
CLDX
$3.48B
$715K 0.41%
25,426
+3,014
+13% +$92.4K
IOVA icon
70
Iovance Biotherapeutics
IOVA
$2.94B
$691K 0.39%
72,104
+27,142
+60% +$313K
CERE
71
DELISTED
Cerevel Therapeutics Holdings, Inc. Common Stock
CERE
$667K 0.38%
23,611
-4,839
-17% -$144K
GHRS icon
72
GH Research
GHRS
$2B
$660K 0.38%
56,769
-7,167
-11% -$90.4K
DSGN icon
73
Design Therapeutics
DSGN
$915M
$638K 0.36%
+38,152
New +$759K
MDGL icon
74
Madrigal Pharmaceuticals
MDGL
$12.4B
$619K 0.35%
9,527
+4,727
+98% +$328K
ISEE
75
DELISTED
IVERIC bio, Inc. Common Stock
ISEE
$611K 0.35%
34,060
-23,859
-41% -$313K
1 2
3
4 5

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HighVista Strategies's Q3 2022 Portfolio in Review

As of Q3 2022, HighVista Strategies held 129 positions worth $175M, up 5.7% from $166M the previous quarter. Its ten largest holdings account for 37% of the portfolio.

HighVista Strategies deployed $6.42M of net new capital in Q3 2022, opening 19 new positions and adding to 30 existing holdings. Its largest new stake was Nielsen Holdings plc: 114,200 shares worth $3.17M.

By sector, the portfolio is most concentrated in Healthcare at 46% of assets, down from 46% a quarter earlier, followed by Technology and Financials.

On the sell side, the largest reduction was Dyne Therapeutics, an estimated $1.6M trimmed.

  • HighVista Strategies's largest Q3 2022 buy was Nielsen Holdings plc: 114,200 shares worth $3.17M.
  • HighVista Strategies added most to Repare Therapeutics in Q3 2022, an estimated $1.95M increase.
  • HighVista Strategies's biggest Q3 2022 reduction was Dyne Therapeutics, cutting an estimated $1.6M.
  • HighVista Strategies fully exited Coherent Inc in Q3 2022, selling an estimated $3.62M.
  • HighVista Strategies's ten largest holdings make up 37% of its $175M portfolio in Q3 2022.
  • HighVista Strategies opened 19 new positions and closed 16 in Q3 2022.
  • HighVista Strategies's portfolio value rose 5.7% quarter-over-quarter to $175M.

Based on HighVista Strategies's 13F filing for Q3 2022, filed 14 Nov 2022.