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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+5.08%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$126M
AUM Growth
-$25.5M
Cap. Flow
-$24.9M
Cap. Flow %
-19.84%
Top 10 Hldgs %
47.53%
Holding
143
New
16
Increased
24
Reduced
11
Closed
74

Top Buys

Rank Stock Value
1
COHR
Coherent Inc
COHR
+$3.51M
2
PBCT
People's United Financial Inc
PBCT
+$3.5M
3
CONE
CyrusOne Inc Common Stock
CONE
+$3.28M
4
FULC icon
Fulcrum Therapeutics
FULC
+$1.78M
5
IVVD icon
Invivyd
IVVD
+$1.69M

Top Sells

Rank Stock Value
1
DELL icon
Dell
DELL
+$19.3M
2
PPD
PPD, Inc. Common Stock
PPD
+$3.5M
3
KSU
Kansas City Southern
KSU
+$3.49M
4
SMIN icon
iShares MSCI India Small-Cap ETF
SMIN
+$3.15M
5
FIVN icon
FIVE9
FIVN
+$2.78M

Sector Composition

Rank Sector Weight
1 Healthcare 52.52%
2 Technology 21.51%
3 Consumer Discretionary 5.99%
4 Communication Services 3.46%
5 Financials 2.78%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PMVP icon
51
PMV Pharmaceuticals
PMVP
$68.3M
$919K 0.73%
39,777
– –
RPTX
52
DELISTED
Repare Therapeutics
RPTX
$917K 0.73%
43,497
+7,393
+20% +$174K
DBC icon
53
Invesco DB Commodity Index Tracking Fund
DBC
$1.72B
$881K 0.7%
42,396
– –
MGNX icon
54
MacroGenics
MGNX
$255M
$867K 0.69%
54,012
– –
SNDX icon
55
Syndax Pharmaceuticals
SNDX
$1.8B
$839K 0.67%
38,347
-7,237
-16% -$134K
KNTE
56
DELISTED
Kinnate Biopharma Inc. Common Stock
KNTE
$820K 0.65%
46,264
-14,641
-24% -$309K
STTK icon
57
Shattuck Labs
STTK
$678M
$759K 0.6%
+89,220
New +$1.23M
ONC
58
BeOne Medicines Ltd
ONC
$41.2B
$699K 0.56%
2,580
-1,969
-43% -$665K
VERV
59
DELISTED
Verve Therapeutics
VERV
$692K 0.55%
18,782
– –
NVTA
60
DELISTED
Invitae Corporation
NVTA
$687K 0.55%
44,967
– –
GHRS icon
61
GH Research
GHRS
$2.07B
$630K 0.5%
+27,010
New +$593K
FMTX
62
DELISTED
Forma Therapeutics Holdings, Inc. Common Stock
FMTX
$578K 0.46%
40,612
+13,901
+52% +$241K
BBIO icon
63
BridgeBio Pharma
BBIO
$16.5B
$565K 0.45%
33,850
+9,198
+37% +$389K
NRIX icon
64
Nurix Therapeutics
NRIX
$2.68B
$544K 0.43%
18,796
– –
OLMA icon
65
Olema Pharmaceuticals
OLMA
$920M
$477K 0.38%
50,942
+29,943
+143% +$620K
IVVD icon
66
Invivyd
IVVD
$203M
$472K 0.38%
+65,068
New +$1.69M
OCUL icon
67
Ocular Therapeutix
OCUL
$2.06B
$411K 0.33%
58,965
-10,097
-15% -$78.4K
AVIR icon
68
Atea Pharmaceuticals
AVIR
$395M
$185K 0.15%
20,659
– –
SPRY icon
69
ARS Pharmaceuticals
SPRY
$581M
$149K 0.12%
22,434
– –
AFMD
70
DELISTED
Affimed
AFMD
– –
-2,182
Closed -$135K
AGEN
71
Agenus
AGEN
$296M
– –
-1,167
Closed -$120K
APLS
72
DELISTED
Apellis Pharmaceuticals
APLS
– –
-19,763
Closed -$651K
ARAY icon
73
Accuray
ARAY
$34.7M
– –
-20,938
Closed -$82K
ATHM icon
74
Autohome
ATHM
$2.66B
– –
-15,521
Closed -$728K
BABA icon
75
Alibaba
BABA
$308B
– –
-18,419
Closed -$2.73M
1 2
3
4 5

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HighVista Strategies's Q4 2021 Portfolio in Review

As of Q4 2021, HighVista Strategies held 143 positions worth $126M, down 17% from $151M the previous quarter. Its ten largest holdings account for 48% of the portfolio.

HighVista Strategies withdrew a net $24.9M in Q4 2021, closing 74 positions and reducing 11 holdings. Its most notable exit was PPD, Inc. Common Stock, an estimated $3.5M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 53% of assets, up from 44% a quarter earlier, followed by Technology and Consumer Discretionary.

Against the trend, HighVista Strategies opened a new position in Coherent Inc worth $3.63M.

  • HighVista Strategies's largest Q4 2021 buy was Coherent Inc: 13,600 shares worth $3.63M.
  • HighVista Strategies added most to Gritstone bio, Inc. Common Stock in Q4 2021, an estimated $1.1M increase.
  • HighVista Strategies's biggest Q4 2021 reduction was Dell, cutting an estimated $19.3M.
  • HighVista Strategies fully exited PPD, Inc. Common Stock in Q4 2021, selling an estimated $3.5M.
  • HighVista Strategies's ten largest holdings make up 48% of its $126M portfolio in Q4 2021.
  • HighVista Strategies opened 16 new positions and closed 74 in Q4 2021.
  • HighVista Strategies's portfolio value fell 17% quarter-over-quarter to $126M.

Based on HighVista Strategies's 13F filing for Q4 2021, filed 14 Feb 2022.