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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
-4.54%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$260M
AUM Growth
-$9.28M
Cap. Flow
+$13.5M
Cap. Flow %
5.19%
Top 10 Hldgs %
25.84%
Holding
172
New
35
Increased
39
Reduced
27
Closed
24

Top Buys

Rank Stock Value
1
PWR icon
Quanta Services
PWR
+$2.34M
2
MTZ icon
MasTec
MTZ
+$2.2M
3
MA icon
Mastercard
MA
+$2.01M
4
IMVT icon
Immunovant
IMVT
+$2M
5
MMM icon
3M
MMM
+$1.98M

Top Sells

Rank Stock Value
1
HCP
HashiCorp, Inc. Class A Common Stock
HCP
+$4.45M
2
AMZN icon
Amazon
AMZN
+$3.36M
3
TEVA icon
Teva Pharmaceuticals
TEVA
+$2.23M
4
LYV icon
Live Nation Entertainment
LYV
+$2.02M
5
GH icon
Guardant Health
GH
+$1.83M

Sector Composition

Rank Sector Weight
1 Healthcare 39.15%
2 Technology 17.75%
3 Industrials 8.61%
4 Consumer Discretionary 6.17%
5 Financials 5%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
XOMA
26
DELISTED
Xoma
XOMA
$2.28M 0.88%
114,548
– –
XENE icon
27
Xenon Pharmaceuticals
XENE
$6.18B
$2.24M 0.86%
66,788
– –
ELVN icon
28
Enliven Therapeutics
ELVN
$4.25B
$2.21M 0.85%
112,459
– –
GH icon
29
Guardant Health
GH
$22.5B
$2.2M 0.85%
51,718
-42,400
-45% -$1.83M
V icon
30
Visa
V
$679B
$2.15M 0.83%
6,127
-300
-5% -$102K
GOOG icon
31
Alphabet (Google) Class C
GOOG
$4.26T
$2.1M 0.81%
13,436
+200
+2% +$36.6K
HPE icon
32
Hewlett Packard
HPE
$72.4B
$2.06M 0.79%
133,500
+74,600
+127% +$1.49M
PWR icon
33
Quanta Services
PWR
$101B
$2.06M 0.79%
+8,100
New +$2.34M
CEG icon
34
Constellation Energy
CEG
$98.9B
$2.04M 0.78%
10,100
+4,000
+66% +$1.07M
BHC icon
35
Bausch Health
BHC
$2.31B
$2.03M 0.78%
+217,600
New +$1.56M
MA icon
36
Mastercard
MA
$495B
$2.03M 0.78%
+3,700
New +$2.01M
JANX icon
37
Janux Therapeutics
JANX
$1.01B
$2.01M 0.78%
74,556
+4,841
+7% +$182K
EWTX icon
38
Edgewise Therapeutics
EWTX
$4.85B
$2.01M 0.77%
91,207
+8,475
+10% +$222K
CSCO icon
39
Cisco
CSCO
$475B
$1.99M 0.77%
32,200
+2,600
+9% +$160K
MMM icon
40
3M
MMM
$94.6B
$1.98M 0.76%
+13,500
New +$1.98M
STX icon
41
Seagate
STX
$185B
$1.95M 0.75%
23,000
+5,700
+33% +$539K
WDC icon
42
Western Digital
WDC
$152B
$1.95M 0.75%
48,300
+13,902
+40% +$659K
PM icon
43
Philip Morris
PM
$291B
$1.92M 0.74%
12,100
+600
+5% +$85K
MTZ icon
44
MasTec
MTZ
$22.1B
$1.9M 0.73%
+16,300
New +$2.2M
ARGX icon
45
argenx
ARGX
$53.6B
$1.9M 0.73%
3,205
-2,542
-44% -$1.6M
GEHC icon
46
GE HealthCare
GEHC
$32.8B
$1.87M 0.72%
23,200
-11,800
-34% -$1.01M
RYTM icon
47
Rhythm Pharmaceuticals
RYTM
$7.9B
$1.86M 0.72%
35,039
-2,387
-6% -$132K
META icon
48
Meta Platforms (Facebook)
META
$1.54T
$1.84M 0.71%
3,200
-2,100
-40% -$1.35M
STZ icon
49
Constellation Brands
STZ
$22.7B
$1.82M 0.7%
9,900
+3,700
+60% +$672K
RCL icon
50
Royal Caribbean
RCL
$81.4B
$1.81M 0.7%
8,800
+2,600
+42% +$614K
1
2
3 4 5

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HighVista Strategies's Q1 2025 Portfolio in Review

As of Q1 2025, HighVista Strategies held 172 positions worth $260M, down 3.5% from $269M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies deployed $13.5M of net new capital in Q1 2025, opening 35 new positions and adding to 39 existing holdings. Its largest new stake was Quanta Services: 8,100 shares worth $2.06M.

By sector, the portfolio is most concentrated in Healthcare at 39% of assets, down from 44% a quarter earlier, followed by Technology and Industrials.

On the sell side, the largest reduction was Amazon, an estimated $3.36M trimmed.

  • HighVista Strategies's largest Q1 2025 buy was Quanta Services: 8,100 shares worth $2.06M.
  • HighVista Strategies added most to Praxis Precision Medicines in Q1 2025, an estimated $1.77M increase.
  • HighVista Strategies's biggest Q1 2025 reduction was Amazon, cutting an estimated $3.36M.
  • HighVista Strategies fully exited HashiCorp, Inc. Class A Common Stock in Q1 2025, selling an estimated $4.45M.
  • HighVista Strategies's ten largest holdings make up 26% of its $260M portfolio in Q1 2025.
  • HighVista Strategies opened 35 new positions and closed 24 in Q1 2025.
  • HighVista Strategies's portfolio value fell 3.5% quarter-over-quarter to $260M.

Based on HighVista Strategies's 13F filing for Q1 2025, filed 15 May 2025.