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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+1.03%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$269M
AUM Growth
-$21.2M
Cap. Flow
-$10M
Cap. Flow %
-3.73%
Top 10 Hldgs %
26.35%
Holding
168
New
26
Increased
41
Reduced
37
Closed
31

Top Buys

Rank Stock Value
1
META icon
Meta Platforms (Facebook)
META
+$3.11M
2
GH icon
Guardant Health
GH
+$2.65M
3
JANX icon
Janux Therapeutics
JANX
+$2.45M
4
APLS
Apellis Pharmaceuticals
APLS
+$2.19M
5
GEHC icon
GE HealthCare
GEHC
+$1.85M

Top Sells

Rank Stock Value
1
CTLT
CATALENT, INC.
CTLT
+$4.58M
2
CPRI icon
Capri Holdings
CPRI
+$3.3M
3
AMGN icon
Amgen
AMGN
+$3.25M
4
CART icon
Maplebear
CART
+$3.2M
5
GEV icon
GE Vernova
GEV
+$2.47M

Sector Composition

Rank Sector Weight
1 Healthcare 43.86%
2 Technology 16.73%
3 Consumer Discretionary 7.18%
4 Communication Services 5.42%
5 Industrials 4.96%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
ELVN icon
26
Enliven Therapeutics
ELVN
$4.35B
$2.53M 0.94%
112,459
– –
GOOG icon
27
Alphabet (Google) Class C
GOOG
$4.35T
$2.52M 0.94%
13,236
+700
+6% +$124K
RVMD icon
28
Revolution Medicines
RVMD
$44.4B
$2.5M 0.93%
57,246
+1,684
+3% +$85K
SWTX
29
DELISTED
SpringWorks Therapeutics
SWTX
$2.48M 0.92%
68,758
+32,906
+92% +$1.15M
PTGX icon
30
Protagonist Therapeutics
PTGX
$9.71B
$2.41M 0.9%
62,518
-26,990
-30% -$1.18M
LQDA icon
31
Liquidia Corp
LQDA
$8.1B
$2.39M 0.89%
203,510
+22,563
+12% +$247K
MLTX icon
32
MoonLake Immunotherapeutics
MLTX
$1.47B
$2.36M 0.88%
43,541
– –
MRUS
33
DELISTED
Merus
MRUS
$2.31M 0.86%
55,039
-18,941
-26% -$910K
GEV icon
34
GE Vernova
GEV
$264B
$2.24M 0.83%
6,800
-7,900
-54% -$2.47M
TEVA icon
35
Teva Pharmaceuticals
TEVA
$42.1B
$2.23M 0.83%
101,300
+16,200
+19% +$295K
SYRE icon
36
Spyre Therapeutics
SYRE
$9.29B
$2.22M 0.82%
95,159
-10,192
-10% -$299K
EWTX icon
37
Edgewise Therapeutics
EWTX
$4.84B
$2.21M 0.82%
82,732
-6,106
-7% -$194K
VERA icon
38
Vera Therapeutics
VERA
$2.27B
$2.21M 0.82%
52,197
+30,187
+137% +$1.34M
TSM icon
39
TSMC
TSM
$2.17T
$2.19M 0.82%
11,100
+800
+8% +$155K
COGT icon
40
Cogent Biosciences
COGT
$7.1B
$2.18M 0.81%
279,673
+54,040
+24% +$539K
AVGO icon
41
Broadcom
AVGO
$2.01T
$2.11M 0.78%
9,100
+200
+2% +$37K
RYTM icon
42
Rhythm Pharmaceuticals
RYTM
$7.95B
$2.1M 0.78%
37,426
– –
V icon
43
Visa
V
$675B
$2.03M 0.76%
6,427
-300
-4% -$90.2K
LYV icon
44
Live Nation Entertainment
LYV
$43B
$2.02M 0.75%
15,600
+1,200
+8% +$151K
APGE icon
45
Apogee Therapeutics
APGE
$10.2B
$1.96M 0.73%
43,190
-18,598
-30% -$948K
INSM icon
46
Insmed
INSM
$29.4B
$1.91M 0.71%
27,612
-17,835
-39% -$1.28M
DYN icon
47
Dyne Therapeutics
DYN
$4.95B
$1.85M 0.69%
78,420
+12,938
+20% +$383K
INDV icon
48
Indivior Pharmaceuticals
INDV
$4.54B
$1.83M 0.68%
142,634
– –
BABA icon
49
Alibaba
BABA
$317B
$1.77M 0.66%
20,857
+500
+2% +$47.2K
CSCO icon
50
Cisco
CSCO
$483B
$1.75M 0.65%
29,600
-2,300
-7% -$131K
1
2
3 4 5

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HighVista Strategies's Q4 2024 Portfolio in Review

As of Q4 2024, HighVista Strategies held 168 positions worth $269M, down 7.3% from $290M the previous quarter. Its ten largest holdings account for 26% of the portfolio.

HighVista Strategies withdrew a net $10M in Q4 2024, closing 31 positions and reducing 37 holdings. Its most notable exit was CATALENT, INC., an estimated $4.58M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 44% of assets, down from 46% a quarter earlier, followed by Technology and Consumer Discretionary.

Against the trend, HighVista Strategies opened a new position in Meta Platforms (Facebook) worth $3.1M.

  • HighVista Strategies's largest Q4 2024 buy was Meta Platforms (Facebook): 5,300 shares worth $3.1M.
  • HighVista Strategies added most to Janux Therapeutics in Q4 2024, an estimated $2.45M increase.
  • HighVista Strategies's biggest Q4 2024 reduction was GE Vernova, cutting an estimated $2.47M.
  • HighVista Strategies fully exited CATALENT, INC. in Q4 2024, selling an estimated $4.58M.
  • HighVista Strategies's ten largest holdings make up 26% of its $269M portfolio in Q4 2024.
  • HighVista Strategies opened 26 new positions and closed 31 in Q4 2024.
  • HighVista Strategies's portfolio value fell 7.3% quarter-over-quarter to $269M.

Based on HighVista Strategies's 13F filing for Q4 2024, filed 14 Feb 2025.