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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+13.28%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$168M
AUM Growth
-$6.63M
Cap. Flow
-$14M
Cap. Flow %
-8.3%
Top 10 Hldgs %
40.66%
Holding
139
New
26
Increased
28
Reduced
31
Closed
34

Sector Composition

Rank Sector Weight
1 Healthcare 46.64%
2 Technology 19.92%
3 Financials 17.76%
4 Consumer Discretionary 3.48%
5 Communication Services 2.68%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake
Capital Flow
NVCR icon
26
NovoCure
NVCR
$2.02B
$2.05M 1.22%
28,007
KURA icon
27
Kura Oncology
KURA
$874M
$2.04M 1.21%
164,113
-33,963
-17% -$494K
APLS
28
DELISTED
Apellis Pharmaceuticals
APLS
$2.02M 1.2%
39,111
-14,431
-27% -$765K
CPARU
29
DELISTED
Catalyst Partners Acquisition Corp. Unit
CPARU
$2.01M 1.19%
200,000
VRNA
30
DELISTED
Verona Pharma
VRNA
$1.79M 1.07%
+68,691
New +$915K
CRNX icon
31
Crinetics Pharmaceuticals
CRNX
$8.93B
$1.72M 1.02%
93,893
+1,846
+2% +$32.5K
EWTX icon
32
Edgewise Therapeutics
EWTX
$4.84B
$1.68M 1%
187,480
+84,018
+81% +$788K
RCUS icon
33
Arcus Biosciences
RCUS
$3.66B
$1.48M 0.88%
71,650
KDNY
34
DELISTED
Chinook Therapeutics, Inc. Common Stock
KDNY
$1.3M 0.77%
49,495
-34,056
-41% -$754K
BMEA icon
35
Biomea Fusion
BMEA
$92.1M
$1.22M 0.72%
144,727
DICE
36
DELISTED
DICE Therapeutics, Inc. Common Stock
DICE
$1.22M 0.72%
+39,064
New +$1.27M
DYN icon
37
Dyne Therapeutics
DYN
$4.95B
$1.19M 0.7%
102,431
CLDX icon
38
Celldex Therapeutics
CLDX
$3.37B
$1.1M 0.65%
24,742
-684
-3% -$24.4K
VTYX
39
DELISTED
Ventyx Biosciences
VTYX
$1.09M 0.65%
+33,256
New +$985K
DBC icon
40
Invesco DB Commodity Index Tracking Fund
DBC
$1.72B
$1.05M 0.62%
42,396
RYTM icon
41
Rhythm Pharmaceuticals
RYTM
$7.95B
$1.03M 0.61%
+35,478
New +$912K
AKRO
42
DELISTED
Akero Therapeutics
AKRO
$1.02M 0.61%
+18,629
New +$798K
BMRN icon
43
BioMarin Pharmaceuticals
BMRN
$13.3B
$1M 0.6%
9,701
-120
-1% -$11.3K
SRPT icon
44
Sarepta Therapeutics
SRPT
$1.81B
$999K 0.59%
7,713
-296
-4% -$34.3K
XENE icon
45
Xenon Pharmaceuticals
XENE
$6.21B
$999K 0.59%
25,340
+2,768
+12% +$101K
ALNY icon
46
Alnylam Pharmaceuticals
ALNY
$29B
$964K 0.57%
4,056
-183
-4% -$39K
FOLD
47
DELISTED
Amicus Therapeutics
FOLD
$944K 0.56%
77,314
+8,484
+12% +$95.5K
PCVX icon
48
Vaxcyte
PCVX
$8.67B
$940K 0.56%
19,606
-1,264
-6% -$49.6K
LKFT
49
Lakefront Biotherapeutics American Depositary Shares
LKFT
$1.76B
$919K 0.55%
20,701
+3,202
+18% +$135K
SWTX
50
DELISTED
SpringWorks Therapeutics
SWTX
$905K 0.54%
34,803
+21,915
+170% +$540K

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HighVista Strategies's Q4 2022 Portfolio in Review

As of Q4 2022, HighVista Strategies held 139 positions worth $168M, down 3.8% from $175M the previous quarter. Its ten largest holdings account for 41% of the portfolio.

HighVista Strategies withdrew a net $14M in Q4 2022, closing 34 positions and reducing 31 holdings. Its most notable exit was Change Healthcare Inc. Common Stock, an estimated $4.46M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 47% of assets, up from 46% a quarter earlier, followed by Technology and Financials.

Against the trend, HighVista Strategies opened a new position in South Jersey Industries, Inc. worth $2.82M.

  • HighVista Strategies's largest Q4 2022 buy was South Jersey Industries, Inc.: 79,500 shares worth $2.82M.
  • HighVista Strategies added most to Axsome Therapeutics in Q4 2022, an estimated $2.29M increase.
  • HighVista Strategies's biggest Q4 2022 reduction was Repare Therapeutics, cutting an estimated $2.08M.
  • HighVista Strategies fully exited Change Healthcare Inc. Common Stock in Q4 2022, selling an estimated $4.46M.
  • HighVista Strategies's ten largest holdings make up 41% of its $168M portfolio in Q4 2022.
  • HighVista Strategies opened 26 new positions and closed 34 in Q4 2022.
  • HighVista Strategies's portfolio value fell 3.8% quarter-over-quarter to $168M.

Based on HighVista Strategies's 13F filing for Q4 2022, filed 14 Feb 2023.