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HighVista Strategies Portfolio holdings

AUM $362M
1-Year Est. Return 230.96%
This Fund
S&P 500
This Quarter Est. Return
+5.08%
1 Year Est. Return
+230.96%
3 Year Est. Return
+518.4%
5 Year Est. Return
+644.94%
10 Year Est. Return
+2,223.31%
AUM
$126M
AUM Growth
-$25.5M
Cap. Flow
-$24.9M
Cap. Flow %
-19.84%
Top 10 Hldgs %
47.53%
Holding
143
New
16
Increased
24
Reduced
11
Closed
74

Top Buys

Rank Stock Value
1
COHR
Coherent Inc
COHR
+$3.51M
2
PBCT
People's United Financial Inc
PBCT
+$3.5M
3
CONE
CyrusOne Inc Common Stock
CONE
+$3.28M
4
FULC icon
Fulcrum Therapeutics
FULC
+$1.78M
5
IVVD icon
Invivyd
IVVD
+$1.69M

Top Sells

Rank Stock Value
1
DELL icon
Dell
DELL
+$19.3M
2
PPD
PPD, Inc. Common Stock
PPD
+$3.5M
3
KSU
Kansas City Southern
KSU
+$3.49M
4
SMIN icon
iShares MSCI India Small-Cap ETF
SMIN
+$3.15M
5
FIVN icon
FIVE9
FIVN
+$2.78M

Sector Composition

Rank Sector Weight
1 Healthcare 52.52%
2 Technology 21.51%
3 Consumer Discretionary 5.99%
4 Communication Services 3.46%
5 Financials 2.78%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
PRTA icon
26
Prothena Corp
PRTA
$468M
$1.39M 1.1%
+28,078
New +$1.56M
MRTX
27
DELISTED
Mirati Therapeutics, Inc. Common Stock
MRTX
$1.35M 1.08%
9,236
+747
+9% +$116K
UTHR icon
28
United Therapeutics
UTHR
$22.7B
$1.35M 1.08%
6,266
+362
+6% +$71.1K
FATE icon
29
Fate Therapeutics
FATE
$322M
$1.35M 1.07%
23,081
+5,947
+35% +$337K
FOLD
30
DELISTED
Amicus Therapeutics
FOLD
$1.31M 1.04%
113,387
– –
IOVA icon
31
Iovance Biotherapeutics
IOVA
$2.9B
$1.27M 1.01%
66,639
+10,363
+18% +$228K
HZNP
32
DELISTED
Horizon Therapeutics Public Limited Company Ordinary Shares
HZNP
$1.22M 0.97%
11,298
– –
ALNY icon
33
Alnylam Pharmaceuticals
ALNY
$29B
$1.2M 0.96%
7,093
+935
+15% +$174K
CLDX icon
34
Celldex Therapeutics
CLDX
$3.37B
$1.15M 0.92%
29,856
+1,390
+5% +$60.6K
KURA icon
35
Kura Oncology
KURA
$874M
$1.15M 0.92%
82,124
+11,236
+16% +$182K
ASND icon
36
Ascendis Pharma A/S
ASND
$16.8B
$1.15M 0.91%
8,541
-1,228
-13% -$183K
VRTX icon
37
Vertex Pharmaceuticals
VRTX
$133B
$1.13M 0.9%
+5,135
New +$999K
VTGN icon
38
VistaGen Therapeutics
VTGN
$11.7M
$1.13M 0.9%
19,234
+4,626
+32% +$301K
MORF
39
DELISTED
Morphic Holding, Inc. Common Stock
MORF
$1.13M 0.9%
23,751
+3,406
+17% +$183K
SWTX
40
DELISTED
SpringWorks Therapeutics
SWTX
$1.11M 0.88%
17,870
+2,276
+15% +$151K
BEAM icon
41
Beam Therapeutics
BEAM
$2.82B
$1.08M 0.86%
13,538
+2,064
+18% +$177K
PTGX icon
42
Protagonist Therapeutics
PTGX
$9.71B
$1.06M 0.84%
30,999
+2,688
+9% +$85K
RNAM
43
DELISTED
Avidity Biosciences
RNAM
$1.05M 0.84%
44,294
-12,558
-22% -$300K
NTRA icon
44
Natera
NTRA
$45.9B
$1.03M 0.82%
11,039
– –
RCKT icon
45
Rocket Pharmaceuticals
RCKT
$397M
$1.02M 0.82%
46,913
+6,242
+15% +$170K
CCCC icon
46
C4 Therapeutics
CCCC
$400M
$1.01M 0.81%
31,493
+2,152
+7% +$85.1K
WHWK
47
Whitehawk Therapeutics
WHWK
$259M
$979K 0.78%
+40,549
New +$1.02M
TIL icon
48
Instil Bio
TIL
$50.3M
$974K 0.78%
2,845
-759
-21% -$293K
RGNX icon
49
Regenxbio
RGNX
$688M
$973K 0.77%
+29,753
New +$1.01M
IDYA icon
50
IDEAYA Biosciences
IDYA
$3.54B
$960K 0.76%
+40,619
New +$944K
1
2
3 4 5

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HighVista Strategies's Q4 2021 Portfolio in Review

As of Q4 2021, HighVista Strategies held 143 positions worth $126M, down 17% from $151M the previous quarter. Its ten largest holdings account for 48% of the portfolio.

HighVista Strategies withdrew a net $24.9M in Q4 2021, closing 74 positions and reducing 11 holdings. Its most notable exit was PPD, Inc. Common Stock, an estimated $3.5M position sold in full.

By sector, the portfolio is most concentrated in Healthcare at 53% of assets, up from 44% a quarter earlier, followed by Technology and Consumer Discretionary.

Against the trend, HighVista Strategies opened a new position in Coherent Inc worth $3.63M.

  • HighVista Strategies's largest Q4 2021 buy was Coherent Inc: 13,600 shares worth $3.63M.
  • HighVista Strategies added most to Gritstone bio, Inc. Common Stock in Q4 2021, an estimated $1.1M increase.
  • HighVista Strategies's biggest Q4 2021 reduction was Dell, cutting an estimated $19.3M.
  • HighVista Strategies fully exited PPD, Inc. Common Stock in Q4 2021, selling an estimated $3.5M.
  • HighVista Strategies's ten largest holdings make up 48% of its $126M portfolio in Q4 2021.
  • HighVista Strategies opened 16 new positions and closed 74 in Q4 2021.
  • HighVista Strategies's portfolio value fell 17% quarter-over-quarter to $126M.

Based on HighVista Strategies's 13F filing for Q4 2021, filed 14 Feb 2022.