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OBIO

Nombre Posición Valor operado Cambio en
acciones 		Cambio en la
participación
RTW Investments
1
RTW Investments
New York
USD 41.2 M +USD 5.11 M +1,250,000 +15%
Perceptive Advisors
2
Perceptive Advisors
New York
USD 21.7 M – – –
BlackRock
3
BlackRock
New York
USD 10.8 M +USD 7.67 M +1,874,673 +295%
Vanguard Capital Management
4
Vanguard Capital Management
Pennsylvania
USD 8.73 M -USD 742 k -181,403 -8%
Geode Capital Management
5
Geode Capital Management
Massachusetts
USD 4.35 M +USD 2.14 M +522,416 +108%
Alyeska Investment Group
6
Alyeska Investment Group
Illinois
USD 4.32 M – – –
PBM
7
Propel Bio Management
California
USD 3.87 M – – –
UBS AM
8
UBS AM
Illinois
USD 2.77 M +USD 2.63 M +642,154 Nuevas
State Street
9
State Street
Massachusetts
USD 2.23 M +USD 1.42 M +346,640 +205%
Rice Hall James & Associates
10
Rice Hall James & Associates
California
USD 1.83 M +USD 1.66 M +404,999 +2,131%
Charles Schwab
11
Charles Schwab
California
USD 1.51 M +USD 344 k +84,045 +32%
Northern Trust
12
Northern Trust
Illinois
USD 1.48 M +USD 922 k +225,366 +191%
UBS Group
13
UBS Group
Switzerland
USD 1.41 M +USD 1.13 M +275,463 +548%
Vanguard Fiduciary Trust
14
Vanguard Fiduciary Trust
Pennsylvania
USD 1.26 M +USD 233 k +57,039 +24%
Vanguard Portfolio Management
15
Vanguard Portfolio Management
Pennsylvania
USD 1.19 M +USD 1.12 M +274,973 Nuevas
DMKJ
16
David M. Knott Jr
USD 1.09 M – – –
Flat Footed LLC
17
Flat Footed LLC
Wyoming
USD 1.08 M +USD 1.03 M +251,372 Nuevas
Simplify Asset Management
18
Simplify Asset Management
Nevada
USD 947 k – – –
Goldman Sachs
19
Goldman Sachs
New York
USD 775 k +USD 100 k +24,364 +16%
DCM
20
DAFNA Capital Management
California
USD 547 k – – –
Renaissance Technologies
21
Renaissance Technologies
New York
USD 388 k +USD 78.1 k +19,100 +27%
IFP Advisors
22
IFP Advisors
Florida
USD 387 k -USD 37.9 k -9,279 -9%
DSC
23
Daytona Street Capital
Missouri
USD 379 k +USD 179 k +43,798 +83%
Bank of New York Mellon
24
Bank of New York Mellon
New York
USD 372 k +USD 352 k +86,103 Nuevas
Bridgeway Capital Management
25
Bridgeway Capital Management
Texas
USD 348 k +USD 40.9 k +10,000 +14%
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