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ACET

Nombre Posición Valor operado Cambio en
acciones 		Cambio en la
participación
RA Capital Management
1
RA Capital Management
Massachusetts
USD 8.06 M -USD 1.97 M -250,000 -21%
OrbiMed
2
OrbiMed
New York
USD 7.3 M -USD 1.44 M -183,157 -18%
Franklin Resources
3
Franklin Resources
California
USD 5.41 M – – –
Citadel Advisors
4
Citadel Advisors
Florida
USD 3.74 M +USD 401 k +50,915 +13%
Vanguard Capital Management
5
Vanguard Capital Management
Pennsylvania
USD 2.97 M +USD 52.8 k +6,704 +2%
Adage Capital Partners
6
Adage Capital Partners
Massachusetts
USD 2.37 M – – –
Renaissance Technologies
7
Renaissance Technologies
New York
USD 2.3 M +USD 263 k +33,354 +14%
SCM
8
Stonepine Capital Management
Oregon
USD 2.12 M +USD 186 k +23,563 +11%
Alyeska Investment Group
9
Alyeska Investment Group
Illinois
USD 1.76 M – – –
Schonfeld Strategic Advisors
10
Schonfeld Strategic Advisors
New York
USD 1.69 M +USD 1.54 M +195,514 Nuevas
Carlyle Group
11
Carlyle Group
District of Columbia
USD 1.59 M – – –
NCM
12
NEXTBio Capital Management
California
USD 1.36 M – – –
Acadian Asset Management
13
Acadian Asset Management
Massachusetts
USD 1.08 M +USD 52.8 k +6,694 +6%
Two Sigma Investments
14
Two Sigma Investments
New York
USD 837 k +USD 423 k +53,733 +125%
Geode Capital Management
15
Geode Capital Management
Massachusetts
USD 827 k -USD 43.4 k -5,501 -5%
DCM
16
DAFNA Capital Management
California
USD 811 k – – –
Bridgeway Capital Management
17
Bridgeway Capital Management
Texas
USD 743 k +USD 677 k +85,959 Nuevas
Marshall Wace
18
Marshall Wace
United Kingdom
USD 687 k +USD 626 k +79,488 Nuevas
Trexquant Investment
19
Trexquant Investment
Connecticut
USD 674 k +USD 271 k +34,336 +79%
Jane Street
20
Jane Street
New York
USD 610 k +USD 264 k +33,477 +90%
Burkehill Global Management
21
Burkehill Global Management
New York
USD 540 k – – –
BlackRock
22
BlackRock
New York
USD 537 k +USD 201 k +25,541 +70%
RP
23
Regeneron Pharmaceuticals
New York
USD 523 k – – –
RC
24
Rangeley Capital
Connecticut
USD 440 k -USD 40.3 k -5,108 -9%
Vanguard Fiduciary Trust
25
Vanguard Fiduciary Trust
Pennsylvania
USD 438 k +USD 2.65 k +336 +0.7%
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