Zymeworks
ZYME
183 hedge funds and large institutions have $1.26B invested in Zymeworks in 2025 Q3 according to their latest regulatory filings, with 25 funds opening new positions, 61 increasing their positions, 65 reducing their positions, and 23 closing their positions.
116% more call options, than puts
Call options by funds: $9.15M | Put options by funds: $4.24M
33% more capital invested
Capital invested by funds: $949M → $1.26B (+$310M)
1% more funds holding
Funds holding: 181 → 183 (+2)
9% more first-time investments, than exits
New positions opened: 25 | Existing positions closed: 23
6% less repeat investments, than reductions
Existing positions increased: 61 | Existing positions reduced: 65
10.63% less ownership
Funds ownership: 108.68% → 98.05% (-11%)
40% less funds holding in top 10
Funds holding in top 10: 5 → 3 (-2)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Millennium Management
New York
|
+$14.2M |
| 2 |
Assenagon Asset Management
Senningerberg,
Luxembourg
|
+$11.9M |
| 3 |
PA
Perceptive Advisors
New York
|
+$11.7M |
| 4 |
VPC
Vestal Point Capital
New York
|
+$8.8M |
| 5 |
Arrowstreet Capital
Boston,
Massachusetts
|
+$4.49M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
BNP Paribas Asset Management
Paris,
France
|
-$25.6M |
| 2 |
UBS AM
Chicago,
Illinois
|
-$10.7M |
| 3 |
PM
Prosight Management
Dallas,
Texas
|
-$8.02M |
| 4 |
RG
Redmile Group
San Francisco,
California
|
-$6.37M |
| 5 |
JP Morgan Chase
New York
|
-$5.84M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
CIAM
201
Caitong International Asset Management
Hong Kong
| – | -$7.08K | -564 | Closed |
|
|
BIG
202
Brooklyn Investment Group
Brooklyn,
New York
| – | -$1.39K | -111 | Closed |
|
|
PD
203
Point72 (DIFC)
Dubai,
United Arab Emirates
| – | -$966 | -77 | Closed |
|
|
CPG
204
Cornerstone Planning Group
Fairfield,
New Jersey
| – | -$439 | -35 | Closed |
|
|
AG
205
AmeriFlex Group
Las Vegas,
Nevada
| – | -$247 | -20 | Closed |
|
206
Northwestern Mutual Wealth Management
Milwaukee,
Wisconsin
| – | -$176 | -14 | Closed |
|
ZYME Hedge Fund Activity: Q3 2025 in Review
183 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Zymeworks (ZYME) for Q3 2025, worth a combined $1.26B — up 33% from $949M a quarter earlier.
Buyers outnumbered sellers: 25 funds opened new ZYME positions and 23 closed out — a net gain of 2 holders — while 61 added to existing stakes and 65 trimmed.
The largest buyer was Millennium Management, adding an estimated $14.2M. The largest seller was BNP Paribas Asset Management, exiting entirely with an estimated $25.6M sold.
- 183 institutional investors held Zymeworks (ZYME) as of Q3 2025, up from 181 in Q2 2025.
- Funds reported $1.26B of Zymeworks stock for Q3 2025, up 33% quarter-over-quarter.
- 25 funds opened new Zymeworks positions in Q3 2025 and 23 closed out, a net change of +2 holders.
- The largest Zymeworks buyer in Q3 2025 was Millennium Management, an estimated $14.2M added.
- The largest Zymeworks seller in Q3 2025 was BNP Paribas Asset Management, an estimated $25.6M sold.
Based on aggregated 13F filings for Q3 2025.