Zai Lab
ZLAB
126 hedge funds and large institutions have $511M invested in Zai Lab in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 36 increasing their positions, 40 reducing their positions, and 44 closing their positions.
5.62% less ownership
Funds ownership: 31.47% → 25.85% (-5.6%)
9% less funds holding
Funds holding: 138 → 126 (-12)
10% less repeat investments, than reductions
Existing positions increased: 36 | Existing positions reduced: 40
25% less first-time investments, than exits
New positions opened: 33 | Existing positions closed: 44
57% less capital invested
Capital invested by funds: $1.19B → $511M (-$681M)
67% less funds holding in top 10
Funds holding in top 10: 6 → 2 (-4)
94% less call options, than puts
Call options by funds: $395K | Put options by funds: $6.48M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
RI
RTW Investments
New York
|
+$109M |
| 2 |
UBS Group
Zurich,
Switzerland
|
+$34.5M |
| 3 |
Citadel Advisors
Miami,
Florida
|
+$16.4M |
| 4 |
Jane Street
New York
|
+$8.94M |
| 5 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
+$8.84M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Capital World Investors
Los Angeles,
California
|
-$206M |
| 2 |
Fidelity Investments
Boston,
Massachusetts
|
-$76.4M |
| 3 |
Janus Henderson Group
London,
|
-$69.5M |
| 4 |
ClearBridge Investments
New York
|
-$40.1M |
| 5 |
Allianz Asset Management
Munich,
Germany
|
-$27.6M |
ZLAB Hedge Fund Activity: Q4 2025 in Review
126 of the 8,267 institutional investors tracked by Wall St. Rank reported a position in Zai Lab (ZLAB) for Q4 2025, worth a combined $511M — down 57% from $1.19B a quarter earlier.
Sellers outnumbered buyers: 44 funds closed out of ZLAB and 33 opened new positions — a net loss of 11 holders — while 40 trimmed existing stakes and 36 added.
The largest buyer was RTW Investments, adding an estimated $109M. The largest seller was Capital World Investors, exiting entirely with an estimated $206M sold.
- 126 institutional investors held Zai Lab (ZLAB) as of Q4 2025, down from 138 in Q3 2025.
- Funds reported $511M of Zai Lab stock for Q4 2025, down 57% quarter-over-quarter.
- 33 funds opened new Zai Lab positions in Q4 2025 and 44 closed out, a net change of -11 holders.
- The largest Zai Lab buyer in Q4 2025 was RTW Investments, an estimated $109M added.
- The largest Zai Lab seller in Q4 2025 was Capital World Investors, an estimated $206M sold.
Based on aggregated 13F filings for Q4 2025.