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Xilio Therapeutics

35 hedge funds and large institutions have $16.2M invested in Xilio Therapeutics in 2025 Q2 according to their latest regulatory filings, with 5 funds opening new positions, 4 increasing their positions, 11 reducing their positions, and 5 closing their positions.

New
Increased
Maintained
Reduced
Closed

0.17% more ownership

Funds ownership: 3.11%3.28% (+0.17%)

0% more funds holding

Funds holding: 3535 (0)

0% more funds holding in top 10

Funds holding in top 10: 55 (0)

0% more first-time investments, than exits

New positions opened: 5 | Existing positions closed: 5

1% less capital invested

Capital invested by funds: $16.3M → $16.2M (-$139K)

64% less repeat investments, than reductions

Existing positions increased: 4 | Existing positions reduced: 11

Holders
35
Holders Change
Holders Change %
0%
% of All Funds
0.46%
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.07%
New
5
Increased
4
Reduced
11
Closed
5
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
GS
1
Gilead Sciences
California
$6.19M
BCLSI
2
Bain Capital Life Sciences Investors
Massachusetts
$3.1M
MC
3
Merck & Co
New Jersey
$1.01M
TPC
4
Takeda Pharmaceutical Company
Japan
$1M
Morgan Stanley
5
Morgan Stanley
New York
$982K +$218K +20,606 +25%
GCM
6
Ghisallo Capital Management
Massachusetts
$906K +$1.01M +95,214 New
Vanguard Group
7
Vanguard Group
Pennsylvania
$783K +$11.5K +1,093 +1%
AIIC
8
AJU IB Investment Company
South Korea
$454K
Fidelity Investments
9
Fidelity Investments
Massachusetts
$348K -$281K -26,586 -42%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$251K -$7.06K -669 -2%
TOCUITCONY
11
Trustees of Columbia University in the City of New York
New York
$170K
UBS Group
12
UBS Group
Switzerland
$163K +$58K +5,491 +47%
Squarepoint
13
Squarepoint
New York
$160K +$178K +16,818 New
Balyasny Asset Management
14
Balyasny Asset Management
Illinois
$135K -$41.9K -3,964 -22%
Renaissance Technologies
15
Renaissance Technologies
New York
$112K -$10.2K -964 -8%
APP
16
Avantax Planning Partners
Iowa
$96.8K -$6.08K -576 -5%
Two Sigma Investments
17
Two Sigma Investments
New York
$53.1K -$4.55K -431 -7%
Northern Trust
18
Northern Trust
Illinois
$45.3K
BCM
19
Bridgeway Capital Management
Texas
$38.1K -$11.3K -1,071 -21%
State Street
20
State Street
Massachusetts
$29.5K
XT
21
XTX Topco
Cayman Islands
$23.6K +$26.2K +2,480 New
LPL Financial
22
LPL Financial
California
$21.1K +$23.4K +2,214 New
SFG
23
SevenBridge Financial Group
Pennsylvania
$17.5K -$15.8K -1,500 -46%
ACA
24
Aptus Capital Advisors
Alabama
$17K -$15.8K -1,500 -46%
Mariner
25
Mariner
Kansas
$17K

XLO Hedge Fund Activity: Q2 2025 in Review

35 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Xilio Therapeutics (XLO) for Q2 2025, worth a combined $16.2M — down 0.85% from $16.3M a quarter earlier.

Fund positioning in XLO was balanced in Q2 2025: 5 funds opened new positions, 5 closed out, 4 added to existing stakes and 11 trimmed.

The largest buyer was Ghisallo Capital Management, opening a new position worth an estimated $1.01M. The largest seller was Fidelity Investments, cutting an estimated $281K.

  • 35 institutional investors held Xilio Therapeutics (XLO) as of Q2 2025, unchanged from Q1 2025.
  • Funds reported $16.2M of Xilio Therapeutics stock for Q2 2025, down 0.85% quarter-over-quarter.
  • 5 funds opened new Xilio Therapeutics positions in Q2 2025 and 5 closed out, a net change of 0 holders.
  • The largest Xilio Therapeutics buyer in Q2 2025 was Ghisallo Capital Management, an estimated $1.01M added.
  • The largest Xilio Therapeutics seller in Q2 2025 was Fidelity Investments, an estimated $281K sold.

Based on aggregated 13F filings for Q2 2025.