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Xilio Therapeutics

35 hedge funds and large institutions have $16.3M invested in Xilio Therapeutics in 2025 Q1 according to their latest regulatory filings, with 6 funds opening new positions, 8 increasing their positions, 7 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

14% more repeat investments, than reductions

Existing positions increased: 8 | Existing positions reduced: 7

0% more funds holding

Funds holding: 3535 (0)

0% more funds holding in top 10

Funds holding in top 10: 55 (0)

0% more first-time investments, than exits

New positions opened: 6 | Existing positions closed: 6

0.93% less ownership

Funds ownership: 4.04%3.11% (-0.93%)

34% less capital invested

Capital invested by funds: $24.7M → $16.3M (-$8.37M)

Holders
35
Holders Change
Holders Change %
0%
% of All Funds
0.47%
Holding in Top 10
5
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.07%
New
6
Increased
8
Reduced
7
Closed
6
Calls
Puts
Net Calls
Net Calls Change
Name Holding Trade Value Shares
Change
Change in
Stake
GS
1
Gilead Sciences
California
$6.6M
BCLSI
2
Bain Capital Life Sciences Investors
Massachusetts
$3.31M
MC
3
Merck & Co
New Jersey
$1.07M
TPC
4
Takeda Pharmaceutical Company
Japan
$1.07M
Morgan Stanley
5
Morgan Stanley
New York
$837K +$139K +11,034 +15%
Vanguard Group
6
Vanguard Group
Pennsylvania
$822K +$209K +16,656 +26%
Fidelity Investments
7
Fidelity Investments
Massachusetts
$640K -$459K -36,559 -37%
AIIC
8
AJU IB Investment Company
South Korea
$484K
Geode Capital Management
9
Geode Capital Management
Massachusetts
$275K +$18.5K +1,471 +6%
Balyasny Asset Management
10
Balyasny Asset Management
Illinois
$184K -$79.8K -6,348 -26%
TOCUITCONY
11
Trustees of Columbia University in the City of New York
New York
$181K
Renaissance Technologies
12
Renaissance Technologies
New York
$129K -$107K -8,494 -40%
UBS Group
13
UBS Group
Switzerland
$118K -$77.5K -6,164 -35%
APP
14
Avantax Planning Partners
Iowa
$109K +$135K +10,743 New
Two Sigma Investments
15
Two Sigma Investments
New York
$60.9K +$65.8K +5,232 +677%
BlackRock
16
BlackRock
New York
$54.1K -$1.24K -99 -2%
BCM
17
Bridgeway Capital Management
Texas
$51.5K
Northern Trust
18
Northern Trust
Illinois
$48.3K +$24.6K +1,957 +70%
Millennium Management
19
Millennium Management
New York
$37K +$45.9K +3,651 New
SFG
20
SevenBridge Financial Group
Pennsylvania
$33.6K +$4.49K +357 +12%
ACA
21
Aptus Capital Advisors
Alabama
$33.3K +$4.49K +357 +12%
State Street
22
State Street
Massachusetts
$31.4K
SRL
23
Scientech Research LLC
New Jersey
$30.8K +$38.2K +3,039 New
ACM
24
ADAR1 Capital Management
Texas
$29K +$35.9K +2,857 New
Raymond James Financial
25
Raymond James Financial
Florida
$24.6K -$14.5K -1,152 -32%

XLO Hedge Fund Activity: Q1 2025 in Review

35 of the 7,459 institutional investors tracked by Wall St. Rank reported a position in Xilio Therapeutics (XLO) for Q1 2025, worth a combined $16.3M — down 34% from $24.7M a quarter earlier.

Fund positioning in XLO was balanced in Q1 2025: 6 funds opened new positions, 6 closed out, 8 added to existing stakes and 7 trimmed.

The largest buyer was Vanguard Group, adding an estimated $209K. The largest seller was Rock Springs Capital Management, exiting entirely with an estimated $2.87M sold.

  • 35 institutional investors held Xilio Therapeutics (XLO) as of Q1 2025, unchanged from Q4 2024.
  • Funds reported $16.3M of Xilio Therapeutics stock for Q1 2025, down 34% quarter-over-quarter.
  • 6 funds opened new Xilio Therapeutics positions in Q1 2025 and 6 closed out, a net change of 0 holders.
  • The largest Xilio Therapeutics buyer in Q1 2025 was Vanguard Group, an estimated $209K added.
  • The largest Xilio Therapeutics seller in Q1 2025 was Rock Springs Capital Management, an estimated $2.87M sold.

Based on aggregated 13F filings for Q1 2025.