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Xenon Pharmaceuticals
XENE

Overview Fund Activity

206 hedge funds and large institutions have $2.58B invested in Xenon Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 20 funds opening new positions, 68 increasing their positions, 73 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
206
Holders Change
-3
Holders Change %
-1.44%
% of All Funds
2.8%
Holding in Top 10
14
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+7.69%
% of All Funds
0.19%
New
20
Increased
68
Reduced
73
Closed
23
Calls
$14.8M
Puts
$6.93M
Net Calls
+$7.9M
Net Calls Change
+$3.62M

Top Buyers

1
DTC
Deep Track Capital
Connecticut
+$27.9M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$25.6M
3
LGM
Logos Global Management
California
+$21.8M
4
Capital International Investors
Capital International Investors
California
+$18.2M
5
VPC
Vestal Point Capital
New York
+$16.4M

Top Sellers

1
BBA
Baker Bros. Advisors
New York
-$21.7M
2
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$21.5M
3
FLAM
First Light Asset Management
Minnesota
-$17.9M
4
CC
Commodore Capital
New York
-$13.9M
5
Federated Hermes
Federated Hermes
Pennsylvania
-$10.9M
Name Holding Trade Value Shares
Change 		Shares
Change %
Bank of New York Mellon
51
Bank of New York Mellon
New York
$8.43M +$6.86M +204,550 +439%
GPP
52
Great Point Partners
Connecticut
$8.23M – – –
Assenagon Asset Management
53
Assenagon Asset Management
Luxembourg
$8.09M +$90K +2,684 +1%
Two Sigma Investments
54
Two Sigma Investments
New York
$7.95M -$1.22M -36,369 -13%
Millennium Management
55
Millennium Management
New York
$7.85M -$3.76M -111,984 -32%
Federated Hermes
56
Federated Hermes
Pennsylvania
$7.8M -$10.9M -326,000 -58%
DnB Asset Management
57
DnB Asset Management
Norway
$7.7M +$880K +26,239 +13%
APM
58
Avidity Partners Management
Texas
$7.68M -$8.22M -245,000 -52%
Dimensional Fund Advisors
59
Dimensional Fund Advisors
Texas
$7.21M -$1.51M -45,110 -17%
Point72 Asset Management
60
Point72 Asset Management
Connecticut
$7.04M +$7.04M +209,759 New
Invesco
61
Invesco
Georgia
$6.9M -$127K -3,791 -2%
GIM
62
Granahan Investment Management
Massachusetts
$6.17M +$49.5K +1,475 +0.8%
Axa
63
Axa
France
$5.88M -$418K -12,446 -7%
PHP
64
Parkman Healthcare Partners
Connecticut
$5.86M -$618K -18,428 -10%
NFGH
65
Nan Fung Group Holdings
Hong Kong
$5.32M +$1.74M +51,925 +49%
Renaissance Technologies
66
Renaissance Technologies
New York
$5.19M +$4.73M +141,000 +1,029%
D.E. Shaw & Co
67
D.E. Shaw & Co
New York
$5.11M +$2.19M +65,215 +75%
BM
68
Bridger Management
New York
$4.93M – – –
New York State Common Retirement Fund
69
New York State Common Retirement Fund
New York
$4.78M +$331K +9,851 +7%
Schroder Investment Management Group
70
Schroder Investment Management Group
United Kingdom
$4.7M -$1.35M -39,453 -22%
Bank of America
71
Bank of America
North Carolina
$4.58M +$995K +29,663 +28%
Morgan Stanley
72
Morgan Stanley
New York
$4.34M +$2.06M +61,429 +90%
ACM
73
ADAR1 Capital Management
Texas
$4.28M +$2.58M +77,001 +152%
Swiss National Bank
74
Swiss National Bank
Switzerland
$4.21M -$33.6K -1,000 -0.8%
AG
75
Algert Global
California
$4.14M -$3.96M -118,002 -49%
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