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Vertex Pharmaceuticals

Name Holding Trade Value Shares
Change
Change in
Stake
Bank of New York Mellon
26
Bank of New York Mellon
New York
$861M -$15.8M -36,479 -2%
Invesco
27
Invesco
Georgia
$845M -$125M -288,401 -14%
Royal Bank of Canada
28
Royal Bank of Canada
Ontario, Canada
$788M +$74M +170,396 +11%
Charles Schwab
29
Charles Schwab
California
$753M +$21.4M +49,374 +3%
Renaissance Technologies
30
Renaissance Technologies
New York
$734M -$6.12M -14,100 -0.9%
VOYA Investment Management
31
VOYA Investment Management
Georgia
$695M +$236M +543,250 +58%
Deutsche Bank
32
Deutsche Bank
Germany
$647M -$85.7M -197,541 -13%
HL
33
Harding Loevner
New Jersey
$555M -$16.8M -38,630 -3%
DZ Bank
34
DZ Bank
Germany
$512M +$344M +791,828 +264%
California Public Employees Retirement System
35
California Public Employees Retirement System
California
$474M -$73M -168,295 -14%
HSBC Holdings
36
HSBC Holdings
United Kingdom
$425M +$42.9M +98,800 +12%
Barclays
37
Barclays
United Kingdom
$396M +$12.3M +28,247 +3%
Wells Fargo
38
Wells Fargo
California
$384M +$22M +50,797 +7%
Nuveen
39
Nuveen
North Carolina
$377M -$13.6M -31,367 -4%
Swiss National Bank
40
Swiss National Bank
Switzerland
$358M -$2.99M -6,900 -0.9%
Swedbank
41
Swedbank
Sweden
$312M +$289M +666,212 New
Sumitomo Mitsui Trust Group
42
Sumitomo Mitsui Trust Group
Japan
$312M -$23M -53,028 -7%
Dimensional Fund Advisors
43
Dimensional Fund Advisors
Texas
$311M +$32.6M +75,045 +13%
Manulife (Manufacturers Life Insurance)
44
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$297M -$27M -62,250 -9%
UBS Group
45
UBS Group
Switzerland
$279M +$9.64M +22,200 +4%
BG
46
Bellevue Group
Switzerland
$278M -$32.7M -75,289 -11%
American Century Companies
47
American Century Companies
Missouri
$275M -$47.1M -108,572 -16%
Pictet Asset Management
48
Pictet Asset Management
Switzerland
$264M -$189M -434,938 -44%
Caisse de Depot et Placement du Quebec (CDPQ)
49
Caisse de Depot et Placement du Quebec (CDPQ)
Quebec, Canada
$260M -$130M -299,444 -35%
Franklin Resources
50
Franklin Resources
California
$259M -$65.4M -150,645 -21%