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UroGen Pharma
URGN

167 hedge funds and large institutions have $1.02B invested in UroGen Pharma in 2025 Q4 according to their latest regulatory filings, with 30 funds opening new positions, 52 increasing their positions, 53 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed

371% more call options, than puts

Call options by funds: $33.9M | Put options by funds: $7.2M

33% more funds holding in top 10

Funds holding in top 10: 3 → 4 (+1)

25% more first-time investments, than exits

New positions opened: 30 | Existing positions closed: 24

15% more capital invested

Capital invested by funds: $891M → $1.02B (+$132M)

4% more funds holding

Funds holding: 161 → 167 (+6)

2% less repeat investments, than reductions

Existing positions increased: 52 | Existing positions reduced: 53

1.67% less ownership

Funds ownership: 95.05% → 93.38% (-1.7%)

Holders
167
Holders Change
+6
Holders Change %
+3.73%
% of All Funds
2.03%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
30
Increased
52
Reduced
53
Closed
24
Calls
$33.9M
Puts
$7.2M
Net Calls
+$26.7M
Net Calls Change
+$1.59M

Top Buyers

1
American Century Companies
American Century Companies
Missouri
+$29.5M
2
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$24.4M
3
MB
MPM BioImpact
Massachusetts
+$17.5M
4
FCM
Frontier Capital Management
Massachusetts
+$17M
5
SCM
Superstring Capital Management
New York
+$13.7M

Top Sellers

1
Toronto Dominion Bank
Toronto Dominion Bank
Ontario, Canada
-$63.7M
2
Millennium Management
Millennium Management
New York
-$18.4M
3
TCM
Tang Capital Management
California
-$14.1M
4
SCM
Soleus Capital Management
Connecticut
-$11.5M
5
JP Morgan Chase
JP Morgan Chase
New York
-$8.42M
Name Holding Trade Value Shares
Change 		Change in
Stake
RI
1
RTW Investments
New York
$106M – – –
PBA
2
Paradigm Biocapital Advisors
New York
$105M +$5.59M +257,564 +6%
BlackRock
3
BlackRock
New York
$60.9M +$428K +19,723 +0.8%
Morgan Stanley
4
Morgan Stanley
New York
$60M +$747K +34,455 +1%
JFG
5
Jefferies Financial Group
New York
$51.5M – – –
SCM
6
Silverarc Capital Management
Massachusetts
$40.7M +$3.5M +161,538 +10%
ACA
7
Acorn Capital Advisors
New York
$33.9M +$4.09M +188,671 +15%
SG Americas Securities
8
SG Americas Securities
New York
$32.3M +$4.78M +220,264 +19%
American Century Companies
9
American Century Companies
Missouri
$31.8M +$29.5M +1,358,812 New
MMH
10
Menora Mivtachim Holdings
Israel
$27M – – –
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
11
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$26.3M +$24.4M +1,125,100 New
D.E. Shaw & Co
12
D.E. Shaw & Co
New York
$22.5M +$1.6M +73,691 +8%
MB
13
MPM BioImpact
Massachusetts
$22M +$17.5M +806,378 +597%
O
14
OrbiMed
New York
$20.5M +$4.05M +186,487 +27%
State Street
15
State Street
Massachusetts
$18.9M -$261K -12,025 -1%
FCM
16
Frontier Capital Management
Massachusetts
$18.3M +$17M +781,620 New
MIFH
17
Migdal Insurance & Financial Holdings
Israel
$18.1M – – –
Citadel Advisors
18
Citadel Advisors
Florida
$17.3M +$2.94M +135,480 +22%
SCM
19
Superstring Capital Management
New York
$16.8M +$13.7M +630,442 +717%
TCM
20
TCG Crossover Management
California
$16.8M – – –
Millennium Management
21
Millennium Management
New York
$14.5M -$18.4M -849,785 -58%
T. Rowe Price Associates
22
T. Rowe Price Associates
Maryland
$14.4M +$5.64M +259,991 +73%
JGC
23
J. Goldman & Co
New York
$12M +$11.1M +513,303 New
WP
24
Woodline Partners
California
$11.7M +$4.22M +194,355 +63%
BCM
25
Boxer Capital Management
California
$11.7M -$1.63M -75,000 -13%
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