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Tenaya Therapeutics
TNYA

97 hedge funds and large institutions have $48.8M invested in Tenaya Therapeutics in 2025 Q4 according to their latest regulatory filings, with 27 funds opening new positions, 30 increasing their positions, 20 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

472% more call options, than puts

Call options by funds: $452K | Put options by funds: $79K

50% more first-time investments, than exits

New positions opened: 27 | Existing positions closed: 18

50% more repeat investments, than reductions

Existing positions increased: 30 | Existing positions reduced: 20

20.02% more ownership

Funds ownership: 21.2% → 41.22% (+20%)

7% more funds holding

Funds holding: 91 → 97 (+6)

12% less capital invested

Capital invested by funds: $55.6M → $48.8M (-$6.76M)

33% less funds holding in top 10

Funds holding in top 10: 3 → 2 (-1)

Holders
97
Holders Change
+6
Holders Change %
+6.59%
% of All Funds
1.18%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.02%
New
27
Increased
30
Reduced
20
Closed
18
Calls
$452K
Puts
$79K
Net Calls
+$373K
Net Calls Change
-$197K

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$5.71M
2
AFM
Anson Funds Management
Texas
+$5.65M
3
Alyeska Investment Group
Alyeska Investment Group
Illinois
+$5.44M
4
Vanguard Group
Vanguard Group
Pennsylvania
+$4.75M
5
BGM
Burkehill Global Management
New York
+$2.72M

Top Sellers

1
Aberdeen Group
Aberdeen Group
United Kingdom
-$973K
2
SSA
Schonfeld Strategic Advisors
New York
-$755K
3
DP
Diadema Partners
New Jersey
-$511K
4
TOCUITCONY
Trustees of Columbia University in the City of New York
New York
-$473K
5
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
-$354K
Name Holding Trade Value Shares
Change 		Change in
Stake
CG
1
Column Group
California
$6.69M – – –
Vanguard Group
2
Vanguard Group
Pennsylvania
$6.09M +$4.75M +3,495,251 +69%
EAM
3
Empery Asset Management
New York
$3.85M +$7.36M +5,414,101 New
Millennium Management
4
Millennium Management
New York
$3.28M +$151K +111,154 +2%
Citadel Advisors
5
Citadel Advisors
Florida
$2.99M +$5.71M +4,200,000 New
AFM
6
Anson Funds Management
Texas
$2.95M +$5.65M +4,152,966 New
Alyeska Investment Group
7
Alyeska Investment Group
Illinois
$2.85M +$5.44M +4,000,000 New
BlackRock
8
BlackRock
New York
$2.81M +$2.21M +1,621,385 +70%
BGM
9
Burkehill Global Management
New York
$1.42M +$2.72M +2,000,000 New
KCM
10
Kalehua Capital Management
Texas
$1.42M +$2.72M +2,000,000 New
Renaissance Technologies
11
Renaissance Technologies
New York
$1.32M +$235K +172,665 +10%
ACM
12
ADAR1 Capital Management
Texas
$1.07M +$2.05M +1,505,300 New
SFM
13
Sphera Funds Management
Israel
$1.07M +$2.04M +1,500,000 New
GCP
14
GSA Capital Partners
United Kingdom
$1.05M +$1.38M +1,016,808 +220%
Marshall Wace
15
Marshall Wace
United Kingdom
$998K +$1.89M +1,388,750 +8,034%
Two Sigma Investments
16
Two Sigma Investments
New York
$901K +$483K +355,507 +39%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$849K +$24.2K +17,820 +2%
EC
18
Euclidean Capital
New York
$723K – – –
AI
19
Alphabet Inc
California
$650K – – –
RBI
20
Raiffeisen Bank International
Austria
$630K +$748K +550,000 +157%
Jane Street
21
Jane Street
New York
$483K +$710K +522,205 +334%
MCP
22
Mirador Capital Partners
California
$414K +$760K +559,024 +2,379%
UBS Group
23
UBS Group
Switzerland
$413K +$521K +382,874 +195%
SG
24
StepStone Group
California
$328K – – –
State Street
25
State Street
Massachusetts
$317K – – –
1
2 3 4 5

TNYA Hedge Fund Activity: Q4 2025 in Review

97 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Tenaya Therapeutics (TNYA) for Q4 2025, worth a combined $48.8M — down 12% from $55.6M a quarter earlier.

Buyers outnumbered sellers: 27 funds opened new TNYA positions and 18 closed out — a net gain of 9 holders — while 30 added to existing stakes and 20 trimmed.

The largest buyer was Citadel Advisors, opening a new position worth an estimated $5.71M. The largest seller was Aberdeen Group, exiting entirely with an estimated $973K sold.

  • 97 institutional investors held Tenaya Therapeutics (TNYA) as of Q4 2025, up from 91 in Q3 2025.
  • Funds reported $48.8M of Tenaya Therapeutics stock for Q4 2025, down 12% quarter-over-quarter.
  • 27 funds opened new Tenaya Therapeutics positions in Q4 2025 and 18 closed out, a net change of +9 holders.
  • The largest Tenaya Therapeutics buyer in Q4 2025 was Citadel Advisors, an estimated $5.71M added.
  • The largest Tenaya Therapeutics seller in Q4 2025 was Aberdeen Group, an estimated $973K sold.

Based on aggregated 13F filings for Q4 2025.