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Syndax Pharmaceuticals

216 hedge funds and large institutions have $953M invested in Syndax Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 31 funds opening new positions, 86 increasing their positions, 66 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed

30% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 66

15% more call options, than puts

Call options by funds: $14.4M | Put options by funds: $12.5M

0.86% more ownership

Funds ownership: 117.37%118.22% (+0.86%)

1% less funds holding

Funds holding: 218216 (-2)

3% less first-time investments, than exits

New positions opened: 31 | Existing positions closed: 32

24% less capital invested

Capital invested by funds: $1.25B → $953M (-$302M)

30% less funds holding in top 10

Funds holding in top 10: 107 (-3)

Holders
216
Holders Change
-2
Holders Change %
-0.92%
% of All Funds
2.84%
Holding in Top 10
7
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-30%
% of All Funds
0.09%
New
31
Increased
86
Reduced
66
Closed
32
Calls
$14.4M
Puts
$12.5M
Net Calls
+$1.84M
Net Calls Change
-$8.34M
Name Holding Trade Value Shares
Change
Change in
Stake
PM
26
Prosight Management
Texas
$10.1M +$5.18M +470,421 +77%
AG
27
Algert Global
California
$9.56M +$1.5M +136,680 +15%
GIM
28
Granahan Investment Management
Massachusetts
$9.28M +$4.86M +441,446 +80%
PHP
29
Parkman Healthcare Partners
Connecticut
$8.13M +$3M +272,826 +46%
Morgan Stanley
30
Morgan Stanley
New York
$7.95M -$15.8M -1,432,680 -63%
Renaissance Technologies
31
Renaissance Technologies
New York
$7.85M +$1.72M +156,273 +23%
Northern Trust
32
Northern Trust
Illinois
$7.22M -$91.4K -8,307 -1%
NCM
33
Nantahala Capital Management
Connecticut
$7.07M +$2.2M +200,000 +36%
Charles Schwab
34
Charles Schwab
California
$6.67M +$249K +22,617 +3%
Ensign Peak Advisors
35
Ensign Peak Advisors
Utah
$6.45M
CS
36
Candriam SCA
Luxembourg
$6.32M +$2.47M +224,650 +50%
CC
37
Casdin Capital
New York
$6.08M +$165K +15,000 +2%
D.E. Shaw & Co
38
D.E. Shaw & Co
New York
$6.04M -$1.57M -143,045 -18%
Citadel Advisors
39
Citadel Advisors
Florida
$5.99M -$25M -2,274,882 -78%
ZP
40
Zimmer Partners
New York
$5.67M +$4.32M +392,641 +184%
RPAM
41
Rhenman & Partners Asset Management
Sweden
$5.38M +$1.55M +141,000 +33%
Two Sigma Investments
42
Two Sigma Investments
New York
$5.22M -$2.45M -223,038 -29%
DCM
43
DAFNA Capital Management
California
$5.09M -$9.91K -900 -0.2%
CM
44
Caption Management
Oklahoma
$4.72M +$3.55M +322,571 +177%
SVCM
45
Saturn V Capital Management
Texas
$4.69M -$5.95M -540,729 -52%
BNP Paribas Financial Markets
46
BNP Paribas Financial Markets
France
$4.68M +$3.11M +282,910 +130%
Dimensional Fund Advisors
47
Dimensional Fund Advisors
Texas
$4.57M +$240K +21,765 +5%
PAI
48
Palo Alto Investors
California
$4.16M
Hudson Bay Capital Management
49
Hudson Bay Capital Management
Connecticut
$4.15M +$2.13M +193,300 +77%
SCM
50
Silverarc Capital Management
Massachusetts
$3.77M -$9.97M -906,260 -69%

SNDX Hedge Fund Activity: Q2 2025 in Review

216 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Syndax Pharmaceuticals (SNDX) for Q2 2025, worth a combined $953M — down 24% from $1.25B a quarter earlier.

Sellers outnumbered buyers: 32 funds closed out of SNDX and 31 opened new positions — a net loss of 1 holder — while 66 trimmed existing stakes and 86 added.

The largest buyer was BlackRock, adding an estimated $21.1M. The largest seller was Citadel Advisors, cutting an estimated $25M.

  • 216 institutional investors held Syndax Pharmaceuticals (SNDX) as of Q2 2025, down from 218 in Q1 2025.
  • Funds reported $953M of Syndax Pharmaceuticals stock for Q2 2025, down 24% quarter-over-quarter.
  • 31 funds opened new Syndax Pharmaceuticals positions in Q2 2025 and 32 closed out, a net change of -1 holder.
  • The largest Syndax Pharmaceuticals buyer in Q2 2025 was BlackRock, an estimated $21.1M added.
  • The largest Syndax Pharmaceuticals seller in Q2 2025 was Citadel Advisors, an estimated $25M sold.

Based on aggregated 13F filings for Q2 2025.