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Syndax Pharmaceuticals

216 hedge funds and large institutions have $953M invested in Syndax Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 31 funds opening new positions, 86 increasing their positions, 66 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed

30% more repeat investments, than reductions

Existing positions increased: 86 | Existing positions reduced: 66

15% more call options, than puts

Call options by funds: $14.4M | Put options by funds: $12.5M

0.86% more ownership

Funds ownership: 117.37%118.22% (+0.86%)

1% less funds holding

Funds holding: 218216 (-2)

3% less first-time investments, than exits

New positions opened: 31 | Existing positions closed: 32

24% less capital invested

Capital invested by funds: $1.25B → $953M (-$302M)

30% less funds holding in top 10

Funds holding in top 10: 107 (-3)

Holders
216
Holders Change
-2
Holders Change %
-0.92%
% of All Funds
2.84%
Holding in Top 10
7
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-30%
% of All Funds
0.09%
New
31
Increased
86
Reduced
66
Closed
32
Calls
$14.4M
Puts
$12.5M
Net Calls
+$1.84M
Net Calls Change
-$8.34M
Name Holding Trade Value Shares
Change
Change in
Stake
BlackRock
1
BlackRock
New York
$97.9M +$21.1M +1,914,656 +22%
KCM
2
Kynam Capital Management
New Jersey
$79.8M
Goldman Sachs
3
Goldman Sachs
New York
$54.3M +$20.6M +1,875,654 +48%
Vanguard Group
4
Vanguard Group
Pennsylvania
$47.1M +$1.79M +162,869 +3%
EP
5
Eversept Partners
New York
$38.1M -$1.62M -146,915 -3%
Bank of America
6
Bank of America
North Carolina
$36M +$10.7M +967,873 +34%
State Street
7
State Street
Massachusetts
$32.2M -$5.82M -528,980 -13%
SC
8
Stempoint Capital
New York
$22.2M +$8.52M +774,040 +48%
Franklin Resources
9
Franklin Resources
California
$22.1M +$3.28M +298,272 +14%
Point72 Asset Management
10
Point72 Asset Management
Connecticut
$19.9M -$20.7M -1,881,233 -47%
CCM
11
Catalio Capital Management
New York
$19.7M +$4.08M +370,811 +21%
KCM
12
Kingdon Capital Management
New York
$19.7M +$1.1M +100,000 +5%
Geode Capital Management
13
Geode Capital Management
Massachusetts
$19.2M +$290K +26,365 +1%
Assenagon Asset Management
14
Assenagon Asset Management
Luxembourg
$19.1M
WP
15
Woodline Partners
California
$17.7M +$10.4K +948 +0.1%
Qube Research & Technologies (QRT)
16
Qube Research & Technologies (QRT)
United Kingdom
$15.6M +$9.15M +831,067 +100%
Millennium Management
17
Millennium Management
New York
$15M +$12.9M +1,169,961 +273%
SFM
18
Sphera Funds Management
Israel
$14.7M -$1.02M -92,410 -6%
SI
19
Sofinnova Investments
California
$14.3M -$8.26M -750,783 -33%
BNP Paribas Asset Management
20
BNP Paribas Asset Management
France
$13.5M +$2.47M +224,171 +18%
UBS Group
21
UBS Group
Switzerland
$13.4M -$3.09M -280,363 -16%
Adage Capital Partners
22
Adage Capital Partners
Massachusetts
$13.4M +$8.81M +800,800 +127%
EAM
23
Eventide Asset Management
Massachusetts
$13.2M +$2.6M +236,019 +20%
ACM
24
Aisling Capital Management
New York
$12.3M +$3.21M +291,806 +28%
SCM
25
Soleus Capital Management
Connecticut
$10.2M +$3.03M +275,500 +34%

SNDX Hedge Fund Activity: Q2 2025 in Review

216 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Syndax Pharmaceuticals (SNDX) for Q2 2025, worth a combined $953M — down 24% from $1.25B a quarter earlier.

Sellers outnumbered buyers: 32 funds closed out of SNDX and 31 opened new positions — a net loss of 1 holder — while 66 trimmed existing stakes and 86 added.

The largest buyer was BlackRock, adding an estimated $21.1M. The largest seller was Citadel Advisors, cutting an estimated $25M.

  • 216 institutional investors held Syndax Pharmaceuticals (SNDX) as of Q2 2025, down from 218 in Q1 2025.
  • Funds reported $953M of Syndax Pharmaceuticals stock for Q2 2025, down 24% quarter-over-quarter.
  • 31 funds opened new Syndax Pharmaceuticals positions in Q2 2025 and 32 closed out, a net change of -1 holder.
  • The largest Syndax Pharmaceuticals buyer in Q2 2025 was BlackRock, an estimated $21.1M added.
  • The largest Syndax Pharmaceuticals seller in Q2 2025 was Citadel Advisors, an estimated $25M sold.

Based on aggregated 13F filings for Q2 2025.