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Summit Therapeutics

238 hedge funds and large institutions have $2.08B invested in Summit Therapeutics in 2025 Q2 according to their latest regulatory filings, with 73 funds opening new positions, 66 increasing their positions, 75 reducing their positions, and 45 closing their positions.

New
Increased
Maintained
Reduced
Closed

64% more call options, than puts

Call options by funds: $126M | Put options by funds: $77.1M

62% more first-time investments, than exits

New positions opened: 73 | Existing positions closed: 45

33% more funds holding in top 10

Funds holding in top 10: 34 (+1)

12% more funds holding

Funds holding: 212238 (+26)

9% more capital invested

Capital invested by funds: $1.91B → $2.08B (+$173M)

0.21% less ownership

Funds ownership: 13.39%13.18% (-0.21%)

12% less repeat investments, than reductions

Existing positions increased: 66 | Existing positions reduced: 75

Holders
238
Holders Change
+26
Holders Change %
+12.26%
% of All Funds
3.13%
Holding in Top 10
4
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+33.33%
% of All Funds
0.05%
New
73
Increased
66
Reduced
75
Closed
45
Calls
$126M
Puts
$77.1M
Net Calls
+$49.1M
Net Calls Change
+$69.3M
Name Holding Trade Value Shares
Change
Change in
Stake
Dimensional Fund Advisors
26
Dimensional Fund Advisors
Texas
$8.08M +$2.14M +93,975 +33%
QF
27
QVT Financial
New York
$7.67M
Bank of New York Mellon
28
Bank of New York Mellon
New York
$7.31M +$62.7K +2,749 +0.8%
Barclays
29
Barclays
United Kingdom
$6.68M +$1.33M +58,212 +23%
Goldman Sachs
30
Goldman Sachs
New York
$6.46M -$6.14M -269,365 -47%
Susquehanna International Group
31
Susquehanna International Group
Pennsylvania
$6.38M +$1.06M +46,474 +18%
Squarepoint
32
Squarepoint
New York
$6.2M +$6.64M +291,222 New
Marshall Wace
33
Marshall Wace
United Kingdom
$5.78M +$6.19M +271,641 New
Deutsche Bank
34
Deutsche Bank
Germany
$5.7M -$3.64M -159,831 -37%
CM
35
Caption Management
Oklahoma
$5.69M +$6.09M +267,255 New
Manulife (Manufacturers Life Insurance)
36
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$5.61M -$4.62M -202,523 -43%
New York State Common Retirement Fund
37
New York State Common Retirement Fund
New York
$5.47M +$5.19M +227,513 +774%
TCM
38
Tang Capital Management
California
$5.32M +$5.7M +250,000 New
Jane Street
39
Jane Street
New York
$5.31M +$770K +33,771 +16%
HF
40
HRT Financial
New York
$5.14M +$5.51M +241,685 New
Wells Fargo
41
Wells Fargo
California
$4.99M +$2.47M +108,450 +86%
RAM
42
Readystate Asset Management
Illinois
$4.85M +$5.2M +227,860 New
JP Morgan Chase
43
JP Morgan Chase
New York
$4.39M -$8.43M -369,512 -64%
VOYA Investment Management
44
VOYA Investment Management
Georgia
$4.38M -$380K -16,652 -7%
Russell Investments Group
45
Russell Investments Group
United Kingdom
$4.34M -$163K -7,126 -3%
Rafferty Asset Management
46
Rafferty Asset Management
New York
$4.23M -$704K -30,889 -13%
TC
47
TwinBeech Capital
New York
$4.07M +$4.36M +191,119 New
GIM
48
Granahan Investment Management
Massachusetts
$3.95M +$1.39M +61,113 +49%
WP
49
Woodline Partners
California
$3.87M +$4.15M +182,012 New
Verition Fund Management
50
Verition Fund Management
Connecticut
$3.87M +$4.15M +181,983 New

SMMT Hedge Fund Activity: Q2 2025 in Review

238 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in Summit Therapeutics (SMMT) for Q2 2025, worth a combined $2.08B — up 9.1% from $1.91B a quarter earlier.

Buyers outnumbered sellers: 73 funds opened new SMMT positions and 45 closed out — a net gain of 28 holders — while 66 added to existing stakes and 75 trimmed.

The largest buyer was Baker Bros. Advisors, adding an estimated $212M. The largest seller was Vanguard Group, cutting an estimated $67.7M.

  • 238 institutional investors held Summit Therapeutics (SMMT) as of Q2 2025, up from 212 in Q1 2025.
  • Funds reported $2.08B of Summit Therapeutics stock for Q2 2025, up 9.1% quarter-over-quarter.
  • 73 funds opened new Summit Therapeutics positions in Q2 2025 and 45 closed out, a net change of +28 holders.
  • The largest Summit Therapeutics buyer in Q2 2025 was Baker Bros. Advisors, an estimated $212M added.
  • The largest Summit Therapeutics seller in Q2 2025 was Vanguard Group, an estimated $67.7M sold.

Based on aggregated 13F filings for Q2 2025.