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SION

Sionna Therapeutics
SION

122 hedge funds and large institutions have $1.82B invested in Sionna Therapeutics in 2026 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 40 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

256% more first-time investments, than exits

New positions opened: 32 | Existing positions closed: 9

33% more repeat investments, than reductions

Existing positions increased: 40 | Existing positions reduced: 30

21% more funds holding

Funds holding: 101 → 122 (+21)

14% more funds holding in top 10

Funds holding in top 10: 7 → 8 (+1)

2.43% more ownership

Funds ownership: 98.48% → 100.91% (+2.4%)

0% more capital invested

Capital invested by funds: $1.81B → $1.82B (+$7.17M)

Holders
122
Holders Change
+21
Holders Change %
+20.79%
% of All Funds
1.5%
Holding in Top 10
8
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+14.29%
% of All Funds
0.1%
New
32
Increased
40
Reduced
30
Closed
9
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Jennison Associates
Jennison Associates
New York
+$12.8M
2
SCM
Sio Capital Management
New York
+$11.2M
3
CS
Candriam SCA
Luxembourg
+$9.04M
4
JP Morgan Chase
JP Morgan Chase
New York
+$8.9M
5
Goldman Sachs
Goldman Sachs
New York
+$8.66M

Top Sellers

Rank Fund Capital Flow
1
PA
Perceptive Advisors
New York
-$19.9M
2
Aberdeen Group
Aberdeen Group
United Kingdom
-$10.5M
3
TGA
TPG GP A
Texas
-$9.54M
4
Invesco
Invesco
Georgia
-$3.83M
5
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$2.86M
Name Holding Trade Value Shares
Change 		Change in
Stake
KCM
26
Kalehua Capital Management
Texas
$7.9M – – –
Franklin Resources
27
Franklin Resources
California
$7.04M – – –
Adage Capital Partners
28
Adage Capital Partners
Massachusetts
$6.01M +$5.72M +150,000 New
UBS Group
29
UBS Group
Switzerland
$5.92M +$2.23M +58,464 +66%
VPM
30
Vanguard Portfolio Management
Pennsylvania
$5.7M +$5.42M +142,081 New
SCM
31
Superstring Capital Management
New York
$5.65M -$1.51M -39,569 -22%
Millennium Management
32
Millennium Management
New York
$5.64M +$2.29M +60,095 +75%
Point72 Asset Management
33
Point72 Asset Management
Connecticut
$5.47M +$5.21M +136,549 New
Alyeska Investment Group
34
Alyeska Investment Group
Illinois
$5.46M – – –
GGI
35
GordonMD Global Investments
California
$5.45M +$5.19M +136,000 New
Morgan Stanley
36
Morgan Stanley
New York
$5.33M +$3.17M +83,147 +167%
Charles Schwab
37
Charles Schwab
California
$4.82M -$131K -3,433 -3%
AGP
38
Artia Global Partners
Florida
$4.8M – – –
Northern Trust
39
Northern Trust
Illinois
$4.68M +$178K +4,660 +4%
VFT
40
Vanguard Fiduciary Trust
Pennsylvania
$4.5M +$4.28M +112,175 New
RSCM
41
Rock Springs Capital Management
Maryland
$3.99M – – –
RPAM
42
Rhenman & Partners Asset Management
Sweden
$3.51M +$3.34M +87,500 New
TD Asset Management
43
TD Asset Management
Ontario, Canada
$3.33M -$1.16M -30,356 -27%
Ameriprise
44
Ameriprise
Minnesota
$3.29M -$751K -19,669 -19%
Fidelity Investments
45
Fidelity Investments
Massachusetts
$3.26M +$3.09M +81,011 +21,097%
DCM
46
Driehaus Capital Management
Illinois
$3.07M -$275K -7,217 -9%
Manulife (Manufacturers Life Insurance)
47
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$2.58M -$190K -4,966 -7%
Bank of America
48
Bank of America
North Carolina
$2.04M +$279K +7,303 +17%
SGM
49
Seven Grand Managers
New York
$2M – – –
IHAM
50
Integral Health Asset Management
New York
$2M +$1.91M +50,000 New
1
2
3 4 5

SION Hedge Fund Activity: Q1 2026 in Review

122 of the 8,128 institutional investors tracked by Wall St. Rank reported a position in Sionna Therapeutics (SION) for Q1 2026, worth a combined $1.82B — up 0.4% from $1.81B a quarter earlier.

Buyers outnumbered sellers: 32 funds opened new SION positions and 9 closed out — a net gain of 23 holders — while 40 added to existing stakes and 30 trimmed.

The largest buyer was Jennison Associates, adding an estimated $12.8M. The largest seller was Perceptive Advisors, cutting an estimated $19.9M.

  • 122 institutional investors held Sionna Therapeutics (SION) as of Q1 2026, up from 101 in Q4 2025.
  • Funds reported $1.82B of Sionna Therapeutics stock for Q1 2026, up 0.4% quarter-over-quarter.
  • 32 funds opened new Sionna Therapeutics positions in Q1 2026 and 9 closed out, a net change of +23 holders.
  • The largest Sionna Therapeutics buyer in Q1 2026 was Jennison Associates, an estimated $12.8M added.
  • The largest Sionna Therapeutics seller in Q1 2026 was Perceptive Advisors, an estimated $19.9M sold.

Based on aggregated 13F filings for Q1 2026.