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Sana Biotechnology
SANA

178 hedge funds and large institutions have $582M invested in Sana Biotechnology in 2025 Q3 according to their latest regulatory filings, with 46 funds opening new positions, 66 increasing their positions, 36 reducing their positions, and 21 closing their positions.

New
Increased
Maintained
Reduced
Closed

119% more first-time investments, than exits

New positions opened: 46 | Existing positions closed: 21

83% more repeat investments, than reductions

Existing positions increased: 66 | Existing positions reduced: 36

46% more capital invested

Capital invested by funds: $398M → $582M (+$184M)

15% more funds holding

Funds holding: 155 → 178 (+23)

4.3% more ownership

Funds ownership: 64.52% → 68.82% (+4.3%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

11% less call options, than puts

Call options by funds: $1.48M | Put options by funds: $1.66M

Holders
178
Holders Change
+23
Holders Change %
+14.84%
% of All Funds
2.34%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
46
Increased
66
Reduced
36
Closed
21
Calls
$1.48M
Puts
$1.66M
Net Calls
-$183K
Net Calls Change
-$973K

Top Buyers

Rank Fund Capital Flow
1
State Street
State Street
Massachusetts
+$13.8M
2
Fidelity Investments
Fidelity Investments
Massachusetts
+$13M
3
Citadel Advisors
Citadel Advisors
Florida
+$13M
4
Renaissance Technologies
Renaissance Technologies
New York
+$6.47M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$5.49M

Top Sellers

Rank Fund Capital Flow
1
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$8.72M
2
Morgan Stanley
Morgan Stanley
New York
-$2.18M
3
CM
Crestline Management
Texas
-$2.17M
4
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$1.92M
5
Corient Private Wealth
Corient Private Wealth
Florida
-$1.15M
Name Holding Trade Value Shares
Change 		Change in
Stake
Corient Private Wealth
26
Corient Private Wealth
Florida
$2.9M -$1.15M -319,000 -28%
Dimensional Fund Advisors
27
Dimensional Fund Advisors
Texas
$2.76M -$783K -216,679 -22%
GPP
28
Great Point Partners
Connecticut
$2.48M +$2.53M +700,000 New
ACH
29
ArrowMark Colorado Holdings
Colorado
$2.43M – – –
Goldman Sachs
30
Goldman Sachs
New York
$2.42M +$1.37M +378,858 +125%
Two Sigma Investments
31
Two Sigma Investments
New York
$2.17M -$6.01K -1,663 -0.3%
Royal Bank of Canada
32
Royal Bank of Canada
Ontario, Canada
$2.08M +$413K +114,371 +24%
Deutsche Bank
33
Deutsche Bank
Germany
$1.93M +$40.4K +11,181 +2%
Barclays
34
Barclays
United Kingdom
$1.87M +$114K +31,441 +6%
CC
35
Clearline Capital
New York
$1.86M +$412K +114,012 +28%
Susquehanna International Group
36
Susquehanna International Group
Pennsylvania
$1.82M +$946K +261,773 +104%
Invesco
37
Invesco
Georgia
$1.61M +$650K +179,776 +66%
Bank of New York Mellon
38
Bank of New York Mellon
New York
$1.44M +$38.6K +10,671 +3%
DekaBank Deutsche Girozentrale
39
DekaBank Deutsche Girozentrale
Germany
$1.21M – – –
N
40
Nuveen
North Carolina
$1.08M – – –
Rafferty Asset Management
41
Rafferty Asset Management
New York
$951K +$969K +267,985 New
Swiss National Bank
42
Swiss National Bank
Switzerland
$931K +$948K +262,300 New
LP
43
LMR Partners
United Kingdom
$861K +$877K +242,553 New
IC
44
IEQ Capital
California
$852K +$817 +226 +0.1%
Jane Street
45
Jane Street
New York
$819K +$317K +87,757 +61%
Squarepoint
46
Squarepoint
New York
$789K +$475K +131,324 +144%
CGL
47
Clarius Group LLC
Washington
$754K – – –
State of Wisconsin Investment Board
48
State of Wisconsin Investment Board
Wisconsin
$704K +$716K +198,179 New
AllianceBernstein
49
AllianceBernstein
Tennessee
$698K – – –
RhumbLine Advisers
50
RhumbLine Advisers
Massachusetts
$695K -$27.4K -7,577 -4%
1
2
3 4 5

SANA Hedge Fund Activity: Q3 2025 in Review

178 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Sana Biotechnology (SANA) for Q3 2025, worth a combined $582M — up 46% from $398M a quarter earlier.

Buyers outnumbered sellers: 46 funds opened new SANA positions and 21 closed out — a net gain of 25 holders — while 66 added to existing stakes and 36 trimmed.

The largest buyer was State Street, adding an estimated $13.8M. The largest seller was T. Rowe Price Associates, cutting an estimated $8.72M.

  • 178 institutional investors held Sana Biotechnology (SANA) as of Q3 2025, up from 155 in Q2 2025.
  • Funds reported $582M of Sana Biotechnology stock for Q3 2025, up 46% quarter-over-quarter.
  • 46 funds opened new Sana Biotechnology positions in Q3 2025 and 21 closed out, a net change of +25 holders.
  • The largest Sana Biotechnology buyer in Q3 2025 was State Street, an estimated $13.8M added.
  • The largest Sana Biotechnology seller in Q3 2025 was T. Rowe Price Associates, an estimated $8.72M sold.

Based on aggregated 13F filings for Q3 2025.