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Ultragenyx Pharmaceutical

299 hedge funds and large institutions have $3.25B invested in Ultragenyx Pharmaceutical in 2025 Q1 according to their latest regulatory filings, with 33 funds opening new positions, 127 increasing their positions, 104 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

40% more funds holding in top 10

Funds holding in top 10: 57 (+2)

22% more repeat investments, than reductions

Existing positions increased: 127 | Existing positions reduced: 104

2.35% more ownership

Funds ownership: 94.76%97.11% (+2.4%)

4% more call options, than puts

Call options by funds: $43.9M | Put options by funds: $42.2M

4% less funds holding

Funds holding: 312299 (-13)

12% less capital invested

Capital invested by funds: $3.68B → $3.25B (-$427M)

25% less first-time investments, than exits

New positions opened: 33 | Existing positions closed: 44

Holders
299
Holders Change
-13
Holders Change %
-4.17%
% of All Funds
4.01%
Holding in Top 10
7
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+40%
% of All Funds
0.09%
New
33
Increased
127
Reduced
104
Closed
44
Calls
$43.9M
Puts
$42.2M
Net Calls
+$1.65M
Net Calls Change
+$8.06M
Name Holding Trade Value Shares
Change
Change in
Stake
DCM
26
Driehaus Capital Management
Illinois
$30.9M +$965K +23,192 +3%
ACA
27
Avoro Capital Advisors
New York
$30.1M
SSA
28
Schonfeld Strategic Advisors
New York
$29.9M +$3.2M +76,989 +10%
CS
29
Candriam SCA
Luxembourg
$26.4M +$2.24M +53,760 +8%
Millennium Management
30
Millennium Management
New York
$25.8M +$631K +15,157 +2%
Bank of New York Mellon
31
Bank of New York Mellon
New York
$25.2M -$1.78M -42,812 -6%
FLSM
32
Frazier Life Sciences Management
California
$23.9M
PCH
33
Polar Capital Holdings
United Kingdom
$23.6M +$27.1M +651,383 New
Two Sigma Investments
34
Two Sigma Investments
New York
$22.9M +$757K +18,204 +3%
FLAM
35
First Light Asset Management
Minnesota
$22.9M -$5.47M -131,574 -17%
EHI
36
Eagle Health Investments
Connecticut
$22.7M
Morgan Stanley
37
Morgan Stanley
New York
$22.7M +$1.17M +28,211 +5%
Franklin Resources
38
Franklin Resources
California
$21.7M +$7.2M +173,087 +41%
Charles Schwab
39
Charles Schwab
California
$21.5M -$853K -20,512 -3%
Northern Trust
40
Northern Trust
Illinois
$20.6M +$1.64M +39,424 +7%
Loomis, Sayles & Company
41
Loomis, Sayles & Company
Massachusetts
$20.3M +$23.4M +561,479 New
D.E. Shaw & Co
42
D.E. Shaw & Co
New York
$20.1M +$11.2M +270,338 +94%
Bank of America
43
Bank of America
North Carolina
$19.1M +$5.8M +139,478 +36%
FAM
44
Fred Alger Management
New York
$19M +$2.43M +58,372 +13%
N
45
Nuveen
North Carolina
$18.8M +$5.4M +129,882 +33%
EA
46
Emerald Advisers
Pennsylvania
$18.7M -$87.4K -2,100 -0.4%
GKIM
47
GW&K Investment Management
Massachusetts
$18.2M -$305K -7,334 -1%
Massachusetts Financial Services
48
Massachusetts Financial Services
Massachusetts
$18.2M +$54.3K +1,306 +0.3%
VPC
49
Vestal Point Capital
New York
$18.1M -$41.6M -1,000,000 -67%
Goldman Sachs
50
Goldman Sachs
New York
$17.4M -$3.05M -73,401 -13%

RARE Hedge Fund Activity: Q1 2025 in Review

299 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Ultragenyx Pharmaceutical (RARE) for Q1 2025, worth a combined $3.25B — down 12% from $3.68B a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of RARE and 33 opened new positions — a net loss of 11 holders — while 104 trimmed existing stakes and 127 added.

The largest buyer was Adage Capital Partners, adding an estimated $40.2M. The largest seller was Vestal Point Capital, cutting an estimated $41.6M.

  • 299 institutional investors held Ultragenyx Pharmaceutical (RARE) as of Q1 2025, down from 312 in Q4 2024.
  • Funds reported $3.25B of Ultragenyx Pharmaceutical stock for Q1 2025, down 12% quarter-over-quarter.
  • 33 funds opened new Ultragenyx Pharmaceutical positions in Q1 2025 and 44 closed out, a net change of -11 holders.
  • The largest Ultragenyx Pharmaceutical buyer in Q1 2025 was Adage Capital Partners, an estimated $40.2M added.
  • The largest Ultragenyx Pharmaceutical seller in Q1 2025 was Vestal Point Capital, an estimated $41.6M sold.

Based on aggregated 13F filings for Q1 2025.