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QTTB

Name Holding Trade Value Shares
Change 		Change in
Stake
DM
1
Deerfield Management
New York
$97.7M +$97.6M +290,391 New
Temasek Holdings
2
Temasek Holdings
Singapore
$60.2M +$60.2M +178,905 New
Fidelity Investments
3
Fidelity Investments
Massachusetts
$53.2M +$55.6M +165,272 New
JP Morgan Chase
4
JP Morgan Chase
New York
$22.8M +$22.7M +67,656 New
VC
5
Vivo Capital
California
$21.7M +$21.7M +64,430 New
MC
6
Maverick Capital
Texas
$12.4M +$13.4M +39,877 New
RSCM
7
Rock Springs Capital Management
Maryland
$10.8M +$10.7M +31,944 New
T. Rowe Price Associates
8
T. Rowe Price Associates
Maryland
$9.41M +$9.4M +27,956 New
Franklin Resources
9
Franklin Resources
California
$6.08M +$6.07M +18,056 New
JGC
10
J. Goldman & Co
New York
$5.09M +$5.08M +15,112 New
RI
11
RTW Investments
New York
$4.21M +$4.2M +12,500 New
SAM
12
Sectoral Asset Management
Quebec, Canada
$4.21M +$4.2M +12,500 New
Lord, Abbett & Co
13
Lord, Abbett & Co
New Jersey
$3.74M +$3.74M +11,111 New
SFM
14
Sphera Funds Management
Israel
$2.49M +$2.48M +7,389 New
Alyeska Investment Group
15
Alyeska Investment Group
Illinois
$2.24M +$2.24M +6,667 New
AG
16
Artal Group
Luxembourg
$1.87M +$1.87M +5,556 New
Jennison Associates
17
Jennison Associates
New York
$1.87M +$1.87M +5,556 New
Victory Capital Management
18
Victory Capital Management
Texas
$1.87M +$1.87M +5,556 New
OAM
19
Oxford Asset Management
United Kingdom
$1.83M +$1.83M +5,447 New
Goldman Sachs
20
Goldman Sachs
New York
$1.73M +$1.73M +5,150 New
Millennium Management
21
Millennium Management
New York
$1.7M +$1.7M +5,051 New
ACP
22
Acuta Capital Partners
California
$1.48M +$1.48M +4,389 New
CC
23
Casdin Capital
New York
$1.12M +$1.12M +3,333 New
MIM
24
Monashee Investment Management
Massachusetts
$842K +$841K +2,500 New
WMSA
25
Weiss Multi-Strategy Advisers
New York
$748K +$747K +2,222 New
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