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PTC Therapeutics

293 hedge funds and large institutions have $5.07B invested in PTC Therapeutics in 2025 Q3 according to their latest regulatory filings, with 55 funds opening new positions, 101 increasing their positions, 105 reducing their positions, and 41 closing their positions.

New
Increased
Maintained
Reduced
Closed

265% more call options, than puts

Call options by funds: $50.2M | Put options by funds: $13.8M

80% more funds holding in top 10

Funds holding in top 10: 59 (+4)

34% more first-time investments, than exits

New positions opened: 55 | Existing positions closed: 41

30% more capital invested

Capital invested by funds: $3.9B → $5.07B (+$1.17B)

4% more funds holding

Funds holding: 283293 (+10)

3.25% more ownership

Funds ownership: 100.83%104.08% (+3.3%)

4% less repeat investments, than reductions

Existing positions increased: 101 | Existing positions reduced: 105

Holders
293
Holders Change
+10
Holders Change %
+3.53%
% of All Funds
3.85%
Holding in Top 10
9
Holding in Top 10 Change
+4
Holding in Top 10 Change %
+80%
% of All Funds
0.12%
New
55
Increased
101
Reduced
105
Closed
41
Calls
$50.2M
Puts
$13.8M
Net Calls
+$36.4M
Net Calls Change
+$31.1M
Name Holding Trade Value Shares
Change
Change in
Stake
Vanguard Group
1
Vanguard Group
Pennsylvania
$509M -$29.1M -558,468 -6%
RI
2
RTW Investments
New York
$475M
BlackRock
3
BlackRock
New York
$438M -$18.2M -349,625 -5%
Wellington Management Group
4
Wellington Management Group
Massachusetts
$302M +$11.7M +224,481 +5%
Janus Henderson Group
5
Janus Henderson Group
United Kingdom
$232M +$31.2M +598,541 +19%
AC
6
Armistice Capital
New York
$201M -$76M -1,458,192 -31%
Toronto Dominion Bank
7
Toronto Dominion Bank
Ontario, Canada
$199M +$41.7M +800,567 +33%
State Street
8
State Street
Massachusetts
$192M +$7.21M +138,329 +5%
D.E. Shaw & Co
9
D.E. Shaw & Co
New York
$133M -$13.7M -263,089 -11%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$120M +$848K +16,285 +0.8%
Citadel Advisors
11
Citadel Advisors
Florida
$106M +$42.2M +810,532 +88%
Fidelity Investments
12
Fidelity Investments
Massachusetts
$98.9M -$5.55M -106,512 -6%
JFG
13
Jefferies Financial Group
New York
$97.3M +$82.5M +1,584,678 New
Bank of America
14
Bank of America
North Carolina
$93.1M +$7.06M +135,628 +10%
TCM
15
Tang Capital Management
California
$92.1M +$20.8M +400,000 +36%
Pictet Asset Management
16
Pictet Asset Management
Switzerland
$86.2M +$19.1M +366,543 +35%
Point72 Asset Management
17
Point72 Asset Management
Connecticut
$74.9M +$63.6M +1,220,642 New
Franklin Resources
18
Franklin Resources
California
$71M -$6.13M -117,726 -9%
DCM
19
Driehaus Capital Management
Illinois
$69.5M +$3.79M +72,723 +7%
Millennium Management
20
Millennium Management
New York
$64.8M +$35M +672,079 +175%
HRCM
21
Hood River Capital Management
Florida
$61.1M +$18.7M +359,280 +56%
Renaissance Technologies
22
Renaissance Technologies
New York
$56.9M -$1.88M -36,000 -4%
Goldman Sachs
23
Goldman Sachs
New York
$53.8M +$5.24M +100,656 +13%
PAI
24
Palo Alto Investors
California
$52.9M +$23.8M +456,144 +112%
BNP Paribas Asset Management
25
BNP Paribas Asset Management
France
$49.1M +$593K +11,384 +1%

PTCT Hedge Fund Activity: Q3 2025 in Review

293 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in PTC Therapeutics (PTCT) for Q3 2025, worth a combined $5.07B — up 30% from $3.9B a quarter earlier.

Buyers outnumbered sellers: 55 funds opened new PTCT positions and 41 closed out — a net gain of 14 holders — while 101 added to existing stakes and 105 trimmed.

The largest buyer was Jefferies Financial Group, opening a new position worth an estimated $82.5M. The largest seller was Armistice Capital, cutting an estimated $76M.

  • 293 institutional investors held PTC Therapeutics (PTCT) as of Q3 2025, up from 283 in Q2 2025.
  • Funds reported $5.07B of PTC Therapeutics stock for Q3 2025, up 30% quarter-over-quarter.
  • 55 funds opened new PTC Therapeutics positions in Q3 2025 and 41 closed out, a net change of +14 holders.
  • The largest PTC Therapeutics buyer in Q3 2025 was Jefferies Financial Group, an estimated $82.5M added.
  • The largest PTC Therapeutics seller in Q3 2025 was Armistice Capital, an estimated $76M sold.

Based on aggregated 13F filings for Q3 2025.