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OptimizeRx
OPRX

110 hedge funds and large institutions have $168M invested in OptimizeRx in 2025 Q2 according to their latest regulatory filings, with 31 funds opening new positions, 32 increasing their positions, 25 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed

343% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 7

147% more call options, than puts

Call options by funds: $3.09M | Put options by funds: $1.25M

65% more capital invested

Capital invested by funds: $102M → $168M (+$66.6M)

28% more repeat investments, than reductions

Existing positions increased: 32 | Existing positions reduced: 25

26% more funds holding

Funds holding: 87 → 110 (+23)

3.89% more ownership

Funds ownership: 63.47% → 67.35% (+3.9%)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

Holders
110
Holders Change
+23
Holders Change %
+26.44%
% of All Funds
1.45%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
31
Increased
32
Reduced
25
Closed
7
Calls
$3.09M
Puts
$1.25M
Net Calls
+$1.84M
Net Calls Change
+$3.44M

Top Buyers

Rank Fund Capital Flow
1
MHP
Manatuck Hill Partners
Connecticut
+$2.9M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$1.71M
3
SSA
Schonfeld Strategic Advisors
New York
+$1.33M
4
Citadel Advisors
Citadel Advisors
Florida
+$1.21M
5
UBS Group
UBS Group
Switzerland
+$990K

Top Sellers

Rank Fund Capital Flow
1
Invesco
Invesco
Georgia
-$2.54M
2
RA
Royce & Associates
New York
-$2.23M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.52M
4
BlackRock
BlackRock
New York
-$1.09M
5
Janney Montgomery Scott
Janney Montgomery Scott
Pennsylvania
-$1.08M
Name Holding Trade Value Shares
Change 		Change in
Stake
Wells Fargo
51
Wells Fargo
California
$331K +$48.3K +4,411 +22%
American Century Companies
52
American Century Companies
Missouri
$325K +$90.6K +8,286 +52%
Two Sigma Advisers
53
Two Sigma Advisers
New York
$311K +$252K +23,023 New
CIS
54
Connors Investor Services
Pennsylvania
$298K -$104K -9,500 -30%
MCM
55
Massar Capital Management
Connecticut
$297K +$241K +22,000 New
Verition Fund Management
56
Verition Fund Management
Connecticut
$294K +$238K +21,792 New
WG
57
Winton Group
United Kingdom
$286K +$232K +21,208 New
Group One Trading
58
Group One Trading
Illinois
$243K +$197K +18,002 New
Millennium Management
59
Millennium Management
New York
$238K -$799K -73,013 -81%
VEA
60
Virtus ETF Advisers
New York
$209K +$170K +15,500 New
PAM
61
Panagora Asset Management
Massachusetts
$172K +$139K +12,709 New
QCM
62
Quantinno Capital Management
New York
$169K +$5.21K +476 +4%
CC
63
Centiva Capital
New York
$166K +$134K +12,274 New
HF
64
HRT Financial
New York
$164K +$133K +12,201 New
MIM
65
MetLife Investment Management
New Jersey
$154K – – –
TI
66
Trexquant Investment
Connecticut
$152K -$470K -43,005 -79%
CC
67
Corton Capital
Ontario, Canada
$138K +$112K +10,194 New
Walleye Trading
68
Walleye Trading
New York
$133K +$108K +9,887 New
Deutsche Bank
69
Deutsche Bank
Germany
$131K – – –
Mirae Asset Global ETFs Holdings
70
Mirae Asset Global ETFs Holdings
Hong Kong
$129K -$12K -1,098 -10%
Simplex Trading
71
Simplex Trading
Illinois
$116K +$24.6K +2,247 +35%
JP Morgan Chase
72
JP Morgan Chase
New York
$111K -$9.13K -835 -9%
Citigroup
73
Citigroup
New York
$87K -$70.8K -6,472 -50%
MCM
74
MAI Capital Management
Ohio
$77K – – –
New York State Common Retirement Fund
75
New York State Common Retirement Fund
New York
$68K – – –
1 2
3
4 5

OPRX Hedge Fund Activity: Q2 2025 in Review

110 of the 7,595 institutional investors tracked by Wall St. Rank reported a position in OptimizeRx (OPRX) for Q2 2025, worth a combined $168M — up 65% from $102M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new OPRX positions and 7 closed out — a net gain of 24 holders — while 32 added to existing stakes and 25 trimmed.

The largest buyer was Manatuck Hill Partners, adding an estimated $2.9M. The largest seller was Invesco, exiting entirely with an estimated $2.54M sold.

  • 110 institutional investors held OptimizeRx (OPRX) as of Q2 2025, up from 87 in Q1 2025.
  • Funds reported $168M of OptimizeRx stock for Q2 2025, up 65% quarter-over-quarter.
  • 31 funds opened new OptimizeRx positions in Q2 2025 and 7 closed out, a net change of +24 holders.
  • The largest OptimizeRx buyer in Q2 2025 was Manatuck Hill Partners, an estimated $2.9M added.
  • The largest OptimizeRx seller in Q2 2025 was Invesco, an estimated $2.54M sold.

Based on aggregated 13F filings for Q2 2025.