American Century Companies
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American Century Companies’s OptimizeRx OPRX Stock Holding History

American Century Companies’s Portfolio OPRX Stock Details OPRX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-24,164
Closed -$495K – 2865
2025
Q3 		$495K Buy
24,164
+95
+0.4% +$1.51K ﹤0.01% 2513
2025
Q2 		$325K Buy
24,069
+8,286
+52% +$90.6K ﹤0.01% 2644
2025
Q1 		$137K Buy
15,783
+1,387
+10% +$8.48K ﹤0.01% 2803
2024
Q4 		$70K Sell
14,396
-216
-1% -$1.21K ﹤0.01% 2859
2024
Q3 		$113K Sell
14,612
-24,772
-63% -$220K ﹤0.01% 2825
2024
Q2 		$394K Sell
39,384
-37,750
-49% -$415K ﹤0.01% 2522
2024
Q1 		$937K Buy
77,134
+32,239
+72% +$468K ﹤0.01% 2177
2023
Q4 		$642K Buy
+44,895
New +$431K ﹤0.01% 2268
2022
Q3 		– Sell
-616,159
Closed -$16.9M – 2464
2022
Q2 		$16.9M Buy
616,159
+27,385
+5% +$811K 0.01% 736
2022
Q1 		$22.2M Buy
588,774
+163,729
+39% +$7.25M 0.02% 662
2021
Q4 		$26.4M Buy
425,045
+43,131
+11% +$3.27M 0.02% 629
2021
Q3 		$32.7M Buy
+381,914
New +$24M 0.02% 563

Other funds holding OPRX

WCA
Whetstone Capital Advisors Shawnee Mission, Kansas $288M AUM 44.06% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
RA
Royce & Associates New York $10.1B AUM 42.88% 1-Year Est. Return
KCM
Kennedy Capital Management St Louis, Missouri $4.72B AUM 36.69% 1-Year Est. Return
RHJA
Rice Hall James & Associates San Diego, California $2.05B AUM 43.16% 1-Year Est. Return
William Blair & Company
William Blair & Company Chicago, Illinois $38.4B AUM 25.71% 1-Year Est. Return
PHP
Parkman Healthcare Partners Stamford, Connecticut $970M AUM 79.46% 1-Year Est. Return
NCGI
Next Century Growth Investors Plymouth, Minnesota $1.38B AUM 102.34% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $3.37T AUM 44.26% 1-Year Est. Return

American Century Companies's OPRX Position: Q4 2025 in Review

American Century Companies sold out of OptimizeRx (OPRX) in Q4 2025, closing a stake of 24,164 shares — an estimated $495K sold.

American Century Companies first reported a position in OPRX in Q3 2021 and held it in 12 quarters. The position peaked at $32.7M in Q3 2021. 129 funds tracked by Wall St. Rank hold OPRX as of Q4 2025.

  • American Century Companies reported no remaining OptimizeRx position as of Q4 2025 after selling out during the quarter.
  • American Century Companies sold 24,164 OptimizeRx shares in Q4 2025, an estimated $495K.
  • American Century Companies first reported a position in OptimizeRx in Q3 2021 and held it in 12 quarters.
  • American Century Companies's OptimizeRx position peaked at $32.7M in Q3 2021.
  • 129 funds tracked by Wall St. Rank held OptimizeRx as of Q4 2025.

Based on American Century Companies's 13F filing for Q4 2025, filed 13 Feb 2026.