Two Sigma Advisers
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Two Sigma Advisers’s OptimizeRx OPRX Stock Holding History

Two Sigma Advisers’s Portfolio OPRX Stock Details OPRX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q3 		– Sell
-23,023
Closed -$311K – 2548
2025
Q2 		$311K Buy
+23,023
New +$252K ﹤0.01% 1945
2024
Q2 		– Sell
-12,900
Closed -$157K – 2618
2024
Q1 		$157K Sell
12,900
-22,100
-63% -$321K ﹤0.01% 2250
2023
Q4 		$501K Sell
35,000
-37,000
-51% -$355K ﹤0.01% 1923
2023
Q3 		$560K Sell
72,000
-74,600
-51% -$812K ﹤0.01% 1755
2023
Q2 		$2.09M Sell
146,600
-44,900
-23% -$639K 0.01% 1178
2023
Q1 		$2.8M Sell
191,500
-5,500
-3% -$92K 0.01% 1084
2022
Q4 		$3.31M Sell
197,000
-120,700
-38% -$2.09M 0.01% 961
2022
Q3 		$4.71M Buy
317,700
+237,100
+294% +$4.69M 0.01% 765
2022
Q2 		$2.21M Buy
80,600
+16,200
+25% +$480K 0.01% 1161
2022
Q1 		$2.43M Buy
64,400
+38,200
+146% +$1.69M 0.01% 1145
2021
Q4 		$1.63M Sell
26,200
-82,500
-76% -$6.25M ﹤0.01% 1298
2021
Q3 		$9.3M Sell
108,700
-53,800
-33% -$3.38M 0.02% 539
2021
Q2 		$10.1M Sell
162,500
-9,200
-5% -$468K 0.03% 562
2021
Q1 		$8.37M Buy
171,700
+151,810
+763% +$7.32M 0.02% 642
2020
Q4 		$620K Buy
+19,890
New +$487K ﹤0.01% 1788

Other funds holding OPRX

WCA
Whetstone Capital Advisors Shawnee Mission, Kansas $380M AUM 20.01% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
Vanguard Group
Vanguard Group Malvern, Pennsylvania $6.9T AUM 27.45% 1-Year Est. Return
RA
Royce & Associates New York $12.4B AUM 64.17% 1-Year Est. Return
KCM
Kennedy Capital Management St Louis, Missouri $5.65B AUM 61.31% 1-Year Est. Return
William Blair & Company
William Blair & Company Chicago, Illinois $38.4B AUM 25.71% 1-Year Est. Return
RHJA
Rice Hall James & Associates San Diego, California $2.05B AUM 43.16% 1-Year Est. Return
PHP
Parkman Healthcare Partners Stamford, Connecticut $977M AUM 110.37% 1-Year Est. Return
MHP
Manatuck Hill Partners Westport, Connecticut $302M AUM 117.41% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $552B AUM 44.19% 1-Year Est. Return

Two Sigma Advisers's OPRX Position: Q3 2025 in Review

Two Sigma Advisers sold out of OptimizeRx (OPRX) in Q3 2025, closing a stake of 23,023 shares — an estimated $311K sold.

Two Sigma Advisers first reported a position in OPRX in Q4 2020 and held it in 15 quarters. The position peaked at $10.1M in Q2 2021. 125 funds tracked by Wall St. Rank hold OPRX as of Q3 2025.

  • Two Sigma Advisers reported no remaining OptimizeRx position as of Q3 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 23,023 OptimizeRx shares in Q3 2025, an estimated $311K.
  • Two Sigma Advisers first reported a position in OptimizeRx in Q4 2020 and held it in 15 quarters.
  • Two Sigma Advisers's OptimizeRx position peaked at $10.1M in Q2 2021.
  • 125 funds tracked by Wall St. Rank held OptimizeRx as of Q3 2025.

Based on Two Sigma Advisers's 13F filing for Q3 2025, filed 14 Nov 2025.