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Olema Pharmaceuticals
OLMA

200 hedge funds and large institutions have $2.27B invested in Olema Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 87 funds opening new positions, 55 increasing their positions, 39 reducing their positions, and 12 closing their positions.

New
Increased
Maintained
Reduced
Closed

625% more first-time investments, than exits

New positions opened: 87 | Existing positions closed: 12

450% more funds holding in top 10

Funds holding in top 10: 2 → 11 (+9)

239% more capital invested

Capital invested by funds: $668M → $2.27B (+$1.6B)

76% more call options, than puts

Call options by funds: $30.8M | Put options by funds: $17.5M

59% more funds holding

Funds holding: 126 → 200 (+74)

41% more repeat investments, than reductions

Existing positions increased: 55 | Existing positions reduced: 39

32.66% more ownership

Funds ownership: 99.49% → 132.15% (+33%)

Holders
200
Holders Change
+74
Holders Change %
+58.73%
% of All Funds
2.43%
Holding in Top 10
11
Holding in Top 10 Change
+9
Holding in Top 10 Change %
+450%
% of All Funds
0.13%
New
87
Increased
55
Reduced
39
Closed
12
Calls
$30.8M
Puts
$17.5M
Net Calls
+$13.3M
Net Calls Change
+$7.65M

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
+$88.9M
2
SL
Siren LLC
Connecticut
+$58.7M
3
Janus Henderson Group
Janus Henderson Group
United Kingdom
+$55.6M
4
CAM
Cormorant Asset Management
Massachusetts
+$48.9M
5
RCM
RA Capital Management
Massachusetts
+$46.3M

Top Sellers

1
DTC
Deep Track Capital
Connecticut
-$34M
2
Pictet Asset Management
Pictet Asset Management
Switzerland
-$20.2M
3
Ameriprise
Ameriprise
Minnesota
-$16.8M
4
UBS Group
UBS Group
Switzerland
-$16M
5
Morgan Stanley
Morgan Stanley
New York
-$15.8M
Name Holding Trade Value Shares
Change 		Change in
Stake
Goldman Sachs
26
Goldman Sachs
New York
$20.4M +$249K +14,008 +2%
IC
27
Ikarian Capital
Texas
$19M +$13.5M +758,654 New
CS
28
Candriam SCA
Luxembourg
$17M -$10.1M -570,243 -46%
VC
29
Vivo Capital
California
$16.8M -$14.8M -834,019 -55%
Morgan Stanley
30
Morgan Stanley
New York
$16.6M -$15.8M -890,084 -57%
FTM
31
First Turn Management
California
$15.4M +$11M +617,714 New
EAM
32
Eventide Asset Management
Massachusetts
$14.2M +$10.1M +569,000 New
Holocene Advisors
33
Holocene Advisors
New York
$12.7M +$9M +506,001 New
Pictet Asset Management
34
Pictet Asset Management
Switzerland
$12.6M -$20.2M -1,133,804 -69%
Millennium Management
35
Millennium Management
New York
$12.5M +$2.97M +167,036 +50%
HWAM
36
Hennion & Walsh Asset Management
New Jersey
$11.2M +$3.61M +202,970 +83%
Northern Trust
37
Northern Trust
Illinois
$11.1M -$671K -37,705 -8%
Charles Schwab
38
Charles Schwab
California
$10.2M +$214K +12,014 +3%
Two Sigma Investments
39
Two Sigma Investments
New York
$9.84M +$5.06M +284,132 +259%
Marshall Wace
40
Marshall Wace
United Kingdom
$9.01M +$6.41M +360,394 New
Squarepoint
41
Squarepoint
New York
$8.22M +$5.6M +314,589 +2,233%
Point72 Asset Management
42
Point72 Asset Management
Connecticut
$7.7M +$1.11M +62,472 +25%
UBS Group
43
UBS Group
Switzerland
$7.34M -$16M -897,094 -75%
Skandinaviska Enskilda Banken (SEB)
44
Skandinaviska Enskilda Banken (SEB)
Sweden
$7.04M +$5.01M +281,687 New
BC
45
Birchview Capital
Vermont
$6.72M +$1.69M +95,000 +55%
JP Morgan Chase
46
JP Morgan Chase
New York
$6.71M +$4.24M +238,340 +791%
CCM
47
Catalio Capital Management
New York
$6.68M +$4.75M +267,058 New
HS
48
HighVista Strategies
Massachusetts
$6.04M -$3.48M -195,690 -45%
Bank of America
49
Bank of America
North Carolina
$5.97M -$10M -563,390 -70%
N
50
Nuveen
North Carolina
$5.74M +$1.8M +101,249 +79%
1
2
3 4 5

OLMA Hedge Fund Activity: Q4 2025 in Review

200 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Olema Pharmaceuticals (OLMA) for Q4 2025, worth a combined $2.27B — up 239% from $668M a quarter earlier.

Buyers outnumbered sellers: 87 funds opened new OLMA positions and 12 closed out — a net gain of 75 holders — while 55 added to existing stakes and 39 trimmed.

The largest buyer was Fidelity Investments, adding an estimated $88.9M. The largest seller was Deep Track Capital, exiting entirely with an estimated $34M sold.

  • 200 institutional investors held Olema Pharmaceuticals (OLMA) as of Q4 2025, up from 126 in Q3 2025.
  • Funds reported $2.27B of Olema Pharmaceuticals stock for Q4 2025, up 239% quarter-over-quarter.
  • 87 funds opened new Olema Pharmaceuticals positions in Q4 2025 and 12 closed out, a net change of +75 holders.
  • The largest Olema Pharmaceuticals buyer in Q4 2025 was Fidelity Investments, an estimated $88.9M added.
  • The largest Olema Pharmaceuticals seller in Q4 2025 was Deep Track Capital, an estimated $34M sold.

Based on aggregated 13F filings for Q4 2025.