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Orchestra BioMed
OBIO

59 hedge funds and large institutions have $47.6M invested in Orchestra BioMed in 2025 Q2 according to their latest regulatory filings, with 22 funds opening new positions, 14 increasing their positions, 16 reducing their positions, and 19 closing their positions.

New
Increased
Maintained
Reduced
Closed

16% more first-time investments, than exits

New positions opened: 22 | Existing positions closed: 19

5% more funds holding

Funds holding: 56 → 59 (+3)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

2.63% less ownership

Funds ownership: 49.97% → 47.33% (-2.6%)

13% less repeat investments, than reductions

Existing positions increased: 14 | Existing positions reduced: 16

41% less capital invested

Capital invested by funds: $81.3M → $47.6M (-$33.7M)

Holders
59
Holders Change
+3
Holders Change %
+5.36%
% of All Funds
0.78%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
22
Increased
14
Reduced
16
Closed
19
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
KCM
Knoll Capital Management
Florida
+$1.33M
2
Millennium Management
Millennium Management
New York
+$1.2M
3
Renaissance Technologies
Renaissance Technologies
New York
+$494K
4
DMKJ
David M. Knott Jr
+$292K
5
RI
RTW Investments
New York
+$292K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$3.69M
2
State Street
State Street
Massachusetts
-$1M
3
Geode Capital Management
Geode Capital Management
Massachusetts
-$856K
4
Vanguard Group
Vanguard Group
Pennsylvania
-$439K
5
Northern Trust
Northern Trust
Illinois
-$404K
Name Holding Trade Value Shares
Change 		Change in
Stake
JP Morgan Chase
51
JP Morgan Chase
New York
$1.26K -$33.5K -11,482 -96%
Carson Wealth (CWM LLC)
52
Carson Wealth (CWM LLC)
Nebraska
$1K +$972 +333 +694%
PD
53
Point72 (DIFC)
United Arab Emirates
$949 +$1.03K +354 New
Nisa Investment Advisors
54
Nisa Investment Advisors
Missouri
$646 -$1.65K -564 -70%
FFO
55
Fortitude Family Office
Arizona
$544 +$593 +203 New
Russell Investments Group
56
Russell Investments Group
United Kingdom
$517 +$563 +193 New
SO
57
Sierra Ocean
California
$319 – – –
EP
58
Essential Partners
California
$11 +$12 +4 New
EWA
59
EverSource Wealth Advisors
Alabama
$3 -$12 -4 -80%
Bank of New York Mellon
60
Bank of New York Mellon
New York
– -$225K -52,490 Closed
N
61
Nuveen
North Carolina
– -$179K -41,729 Closed
RhumbLine Advisers
62
RhumbLine Advisers
Massachusetts
– -$135K -31,657 Closed
Deutsche Bank
63
Deutsche Bank
Germany
– -$86.5K -20,219 Closed
IIM
64
INTECH Investment Management
Florida
– -$68.5K -16,002 Closed
Mirae Asset Global ETFs Holdings
65
Mirae Asset Global ETFs Holdings
Hong Kong
– -$64.4K -15,043 Closed
CF
66
Corebridge Financial
Texas
– -$51.5K -12,030 Closed
SEI Investments
67
SEI Investments
Pennsylvania
– -$44K -10,290 Closed
MCM
68
Massar Capital Management
Connecticut
– -$42.8K -10,000 Closed
PFSRSONJ
69
Police & Firemen's Retirement System of New Jersey
New Jersey
– -$20K -4,671 Closed
New York State Common Retirement Fund
70
New York State Common Retirement Fund
New York
– -$15.5K -3,623 Closed
Legal & General Group
71
Legal & General Group
United Kingdom
– -$9.52K -2,225 Closed
California State Teachers Retirement System (CalSTRS)
72
California State Teachers Retirement System (CalSTRS)
California
– -$8.1K -1,893 Closed
AIP
73
Ameritas Investment Partners
Nebraska
– -$5.97K -1,396 Closed
AB
74
Amalgamated Bank
New York
– -$4K -847 Closed
Northwestern Mutual Wealth Management
75
Northwestern Mutual Wealth Management
Wisconsin
– -$1.91K -447 Closed
1 2
3
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OBIO Hedge Fund Activity: Q2 2025 in Review

59 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Orchestra BioMed (OBIO) for Q2 2025, worth a combined $47.6M — down 41% from $81.3M a quarter earlier.

Buyers outnumbered sellers: 22 funds opened new OBIO positions and 19 closed out — a net gain of 3 holders — while 14 added to existing stakes and 16 trimmed.

The largest buyer was Knoll Capital Management, opening a new position worth an estimated $1.33M. The largest seller was BlackRock, cutting an estimated $3.69M.

  • 59 institutional investors held Orchestra BioMed (OBIO) as of Q2 2025, up from 56 in Q1 2025.
  • Funds reported $47.6M of Orchestra BioMed stock for Q2 2025, down 41% quarter-over-quarter.
  • 22 funds opened new Orchestra BioMed positions in Q2 2025 and 19 closed out, a net change of +3 holders.
  • The largest Orchestra BioMed buyer in Q2 2025 was Knoll Capital Management, an estimated $1.33M added.
  • The largest Orchestra BioMed seller in Q2 2025 was BlackRock, an estimated $3.69M sold.

Based on aggregated 13F filings for Q2 2025.