|
1
|
Franklin Resources
San Mateo,
California
|
$442M
|
+$49.4M
|
+1,290,399
|
+75%
|
|
|
2
|
RA Capital Management
Boston,
Massachusetts
|
$397M
|
+$182M
|
+4,758,833
|
New
|
|
|
3
|
Vanguard Group
Malvern,
Pennsylvania
|
$387M
|
+$98.7M
|
+2,579,671
|
+125%
|
|
|
4
|
|
$383M
|
+$70.4M
|
+1,841,506
|
+67%
|
|
|
5
|
State Street
Boston,
Massachusetts
|
$193M
|
+$66.3M
|
+1,733,715
|
+299%
|
|
|
6
|
|
$82.9M
|
+$31.9M
|
+834,271
|
+520%
|
|
|
7
|
Geode Capital Management
Boston,
Massachusetts
|
$75M
|
+$10.8M
|
+283,572
|
+46%
|
|
|
8
|
Citadel Advisors
Miami,
Florida
|
$65M
|
+$28.8M
|
+751,875
|
+2,635%
|
|
|
9
|
Northern Trust
Chicago,
Illinois
|
$59M
|
+$10.4M
|
+272,488
|
+63%
|
|
|
10
|
|
$54.5M
|
+$24.6M
|
+642,369
|
+5,330%
|
|
|
11
|
Rock Springs Capital Management
Baltimore,
Maryland
|
$47.6M
|
+$21.8M
|
+570,598
|
New
|
|
|
12
|
Nuveen
Charlotte,
North Carolina
|
$40.5M
|
+$11.3M
|
+296,579
|
+156%
|
|
|
13
|
Capital World Investors
Los Angeles,
California
|
$37M
|
+$17M
|
+444,228
|
New
|
|
|
14
|
|
$33.3M
|
-$4.72M
|
-123,498
|
-24%
|
|
|
15
|
Charles Schwab
San Francisco,
California
|
$33.2M
|
+$4.46M
|
+116,715
|
+41%
|
|
|
16
|
Perceptive Advisors
New York
|
$29.2M
|
+$13.4M
|
+350,000
|
New
|
|
|
17
|
HHLR Advisors
Grand Cayman,
Cayman Islands
|
$27.2M
|
+$12.5M
|
+326,038
|
New
|
|
|
18
|
Bank of New York Mellon
New York
|
$24.5M
|
+$4.97M
|
+129,940
|
+79%
|
|
|
19
|
|
$20.7M
|
-$7.17M
|
-187,576
|
-43%
|
|
|
20
|
Baker Bros. Advisors
New York
|
$20.1M
|
+$9.23M
|
+241,376
|
New
|
|
|
21
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$19.1M
|
+$8.75M
|
+228,704
|
New
|
|
|
22
|
|
$17.9M
|
+$7.11M
|
+185,961
|
+655%
|
|
|
23
|
Adage Capital Partners
Boston,
Massachusetts
|
$16.6M
|
+$7.63M
|
+199,600
|
New
|
|
|
24
|
|
$16.2M
|
+$703K
|
+18,384
|
+10%
|
|
|
25
|
Millennium Management
New York
|
$13.2M
|
-$18.1M
|
-472,646
|
-75%
|
|
