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Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$68.2M +$5.25M +93,275 +9%
RCM
2
RA Capital Management
Massachusetts
$65.5M +$10.2M +181,460 +21%
BFA
3
BlackRock Fund Advisors
California
$17.8M +$2.43M +43,182 +18%
Wellington Management Group
4
Wellington Management Group
Massachusetts
$15.7M +$13.9M +246,095 +8,821%
CCM
5
Camber Capital Management
Massachusetts
$14.9M +$4.22M +75,000 +47%
BIT
6
BlackRock Institutional Trust
California
$13.6M -$187K -3,317 -2%
Vanguard Group
7
Vanguard Group
Pennsylvania
$13.5M +$1.74M +30,942 +17%
T. Rowe Price Associates
8
T. Rowe Price Associates
Maryland
$13.5M +$11.9M +210,860 +8,878%
HM
9
HealthCor Management
New York
$11M +$9.85M +174,900 New
Franklin Resources
10
Franklin Resources
California
$9.48M +$8.45M +150,000 New
State Street
11
State Street
Massachusetts
$6.74M +$283K +5,029 +5%
Northern Trust
12
Northern Trust
Illinois
$6.13M +$254K +4,505 +5%
BBA
13
Baker Bros. Advisors
New York
$5.41M +$4.83M +85,846 New
IIM
14
Ironwood Investment Management
Massachusetts
$4.98M +$83.4K +1,481 +2%
TC
15
TFS Capital
Pennsylvania
$4.47M +$3.52M +62,560 +743%
DM
16
Deerfield Management
New York
$3.39M +$3.03M +53,849 New
WHI
17
William Harris Investors
Illinois
$3.28M +$2.93M +52,000 New
SM
18
Sabby Management
Florida
$2.77M +$2.46M +43,750 New
Morgan Stanley
19
Morgan Stanley
New York
$2.6M +$1.93M +34,341 +493%
First Eagle Investment Management
20
First Eagle Investment Management
New York
$2.53M +$2.25M +40,000 New
BC
21
Broadfin Capital
New York
$2.52M +$2.25M +40,000 New
Bank of New York Mellon
22
Bank of New York Mellon
New York
$2.36M +$230K +4,091 +12%
Geode Capital Management
23
Geode Capital Management
Massachusetts
$2.11M +$209K +3,703 +13%
MCM
24
McKinley Capital Management
Alaska
$2.08M +$2.2K +39 +0.1%
AWMDMG
25
Austin W. Marxe & David M. Greenhouse
New York
$2.01M +$1.79M +31,850 New
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